Change in the mean number of regular medicines per person.

<p>Closed bars are the intervention group. Open bars are the control group. Error bars are 1 SEM.</p

Adverse outcomes.

<p>Adverse outcomes.</p

Baseline demographic and clinical data.

<p>Baseline demographic and clinical data.</p

Change in bowel function following deprescribing.

<p>Change in bowel function following deprescribing.</p

Recruitment and Participation.

<p>Recruitment and Participation.</p

Kaplan Meier survival plot to 12 months post-randomisation.

<p>Kaplan Meier survival plot to 12 months post-randomisation.</p

Deprescribing Outcomes.

<p>“Withdrawal Achieved” means medicine ceased or changed to PRN used less frequently than once per week at the last follow-up assessment point; RN, registered nurse; NOK, next of kin; GP, general practitioner. Percentages for “Withdrawal Failed” and “Withdrawal Achieved” are calculated as a percentage of the “Withdrawal Attempted” total. Italic numbers in () in the two large explanatory boxes refer to number of people.</p

Withdrawal success rates for medicines deprescribed in ten or more participants.

<p>Withdrawal success rates for medicines deprescribed in ten or more participants.</p

The bars depict the incidence rate of affective episodes per 1000 person-years for each age group, and the whiskers represent the 95% confidence interval of the rates.

<p>The left and right bars for each age group show the results for men without and with Parkinson’s disease respectively.</p

Clinical characteristics of the study cohort and of men with Parkinson’s disease at the start of the follow up period.

<p>Clinical characteristics of the study cohort and of men with Parkinson’s disease at the start of the follow up period.</p