Table3_Does the scarcity of urban space resources make the quality of underground space planning more sustainable? A case study of 40 urban underground space master plans in China.XLSX

The international community has reached a consensus on promoting the sustainable development of global cities. As an important and irreversible space resource in a city, the development and utilization of urban underground space should follow the principle of sustainability and emphasize scientific and forward-looking planning. At present, most cities have formulated urban underground space master plans. However, due to the lack of an effective evaluation method, the plan quality is uneven, which directly affects the sustainability of underground space development and utilization. This paper proposes a set of sustainability evaluation framework of underground space planning based on relevant planning standards and plan quality evaluation protocol, and makes a comparative analysis of the 40 urban underground space master plans formulated in China from 2004 to 2020. The research found that the planning documents generally reflected the problem of emphasizing design strategies and engineering technology while neglecting implementation and humanistic care; administrative region, population density, land price and other variables closely related to the scarcity of urban space resources are the main factors affecting the quality of urban underground space planning. The conclusions of this paper can aid planners and researchers to identify the problems and influencing factors of underground space planning related to sustainability, and summarize the methods to improve the quality of underground space planning.</p

Superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), malondialdehyde (MDA) content of <i>Sorghum bicolor</i> (L.) Moench seedlings under various salt and alkali stresses.

Superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), malondialdehyde (MDA) content of Sorghum bicolor (L.) Moench seedlings under various salt and alkali stresses.</p

Plant height, the maximum leave areas, root length, biomass and relative growth rate (RGR) of <i>Sorghum bicolor</i> (L.) Moench seedlings under various salt and alkali stresses.

Plant height, the maximum leave areas, root length, biomass and relative growth rate (RGR) of Sorghum bicolor (L.) Moench seedlings under various salt and alkali stresses.</p

Table4_Does the scarcity of urban space resources make the quality of underground space planning more sustainable? A case study of 40 urban underground space master plans in China.DOCX

The international community has reached a consensus on promoting the sustainable development of global cities. As an important and irreversible space resource in a city, the development and utilization of urban underground space should follow the principle of sustainability and emphasize scientific and forward-looking planning. At present, most cities have formulated urban underground space master plans. However, due to the lack of an effective evaluation method, the plan quality is uneven, which directly affects the sustainability of underground space development and utilization. This paper proposes a set of sustainability evaluation framework of underground space planning based on relevant planning standards and plan quality evaluation protocol, and makes a comparative analysis of the 40 urban underground space master plans formulated in China from 2004 to 2020. The research found that the planning documents generally reflected the problem of emphasizing design strategies and engineering technology while neglecting implementation and humanistic care; administrative region, population density, land price and other variables closely related to the scarcity of urban space resources are the main factors affecting the quality of urban underground space planning. The conclusions of this paper can aid planners and researchers to identify the problems and influencing factors of underground space planning related to sustainability, and summarize the methods to improve the quality of underground space planning.</p

Table1_Does the scarcity of urban space resources make the quality of underground space planning more sustainable? A case study of 40 urban underground space master plans in China.XLSX

The international community has reached a consensus on promoting the sustainable development of global cities. As an important and irreversible space resource in a city, the development and utilization of urban underground space should follow the principle of sustainability and emphasize scientific and forward-looking planning. At present, most cities have formulated urban underground space master plans. However, due to the lack of an effective evaluation method, the plan quality is uneven, which directly affects the sustainability of underground space development and utilization. This paper proposes a set of sustainability evaluation framework of underground space planning based on relevant planning standards and plan quality evaluation protocol, and makes a comparative analysis of the 40 urban underground space master plans formulated in China from 2004 to 2020. The research found that the planning documents generally reflected the problem of emphasizing design strategies and engineering technology while neglecting implementation and humanistic care; administrative region, population density, land price and other variables closely related to the scarcity of urban space resources are the main factors affecting the quality of urban underground space planning. The conclusions of this paper can aid planners and researchers to identify the problems and influencing factors of underground space planning related to sustainability, and summarize the methods to improve the quality of underground space planning.</p

Insights into the Dissociation Process and Binding Pattern of the BRCT7/8-PHF8 Complex

DNA topoisomerase 2-binding protein 1 (Topbp1) plays a crucial role in activating the ataxia-telangiectasia mutated and rad3-related (ATR) complex to initiate DNA damage repair responses. For this process to occur, it is necessary for PHF8 to dissociate from Topbp1. Topbp1 binds to the acidic patch sequence (APS) of PHF8 through its C-terminal BRCT7/8 domain, and disrupting this interaction could be a promising strategy for cancer treatment. To investigate the dissociation process and binding pattern of BRCT7/8-PHF8, we employed enhanced sampling techniques, such as steered molecular dynamics (SMD) simulations and accelerated molecular dynamics (aMD) simulations, along with self-organizing maps (SOM) and time-resolved force distribution analysis (TRFDA) methodologies. Our results demonstrate that the dissociation of PHF8 from BRCT7/8 starts from the N-terminus, leading to the unfolding of the N-terminal helix. Additionally, we identified critical residues that play a pivotal role in this dissociation process. These findings provide valuable insights into the disassociation of PHF8 from BRCT7/8, which could potentially guide the development of novel drugs targeting Topbp1 for cancer therapy

Response of proline and soluble protein content of sorghum to saline-alkali stress.

(A)Proline content. (B) Soluble protein content. Note: Values represent means±S.E. Values at each treatment group followed by different letters are significantly different (P < 0.05).</p

Cationic Zinc(II) Complexes with Carbazole-Type Counter-Anions: Intracomplex Donor/Acceptor Pairs Affording Exciplexes with Thermally Activated Delayed Fluorescence

Two cationic zinc(II) complexes with carbazole-type counter-anions, namely, [Zn(tpy)2]2+[CAZ-p-BF3–]2 (Zn-p) and [Zn(tpy)2]2+[CAZ-o-BF3–]2 (Zn-o), have been designed and synthesized, where tpy is 2,2′:6′,2″-terpyridine, CAZ-p-BF3– is 4-((9H-carbazol-9-yl)phenyl)trifluoroborate, and CAZ-o-BF3– is (2-(9H-carbazol-9-yl)phenyl)trifluoroborate. The complex cation [Zn(tpy)2]2+ (as the acceptor) and the carbazole-type counter-anion CAZ-p-BF3– or CAZ-o-BF3– (as the donor) form an intracomplex donor/acceptor pair. Single-crystal structures reveal that compared to Zn-p, Zn-o exhibits a stronger π–π stacking interaction between the carbazole group (as the donor unit) of the counter-anion and the tpy ligand (as the acceptor unit) of [Zn(tpy)2]2+ because of the different anchoring position of the BF3– anion in the counter-anion. In a doped film, Zn-p and Zn-o afford an isolated exciplex formed between the carbazole group and the tpy ligand within the single complex, which gives green-yellow emission with a thermally activated delayed fluorescence (TADF) feature. In crystalline states, Zn-p and Zn-o afford exciplexes with blue emission centered at 468 nm and green-blue emission centered at 508 nm, respectively. The Zn-p crystalline sample shows a relatively large singlet–triplet energy gap (ΔEST) (0.33 eV) and no TADF, whereas the Zn-o crystalline sample exhibits a small ΔEST (0.06 eV) and distinct TADF, with a reverse intersystem crossing rate at 3.3 × 105 s–1. Zn-p and Zn-o both exhibit intriguing mechanochromic luminescence, with largely red-shifted (by over 70 nm) emission and modulated TADF properties upon mechanically grinding the crystalline samples. The work demonstrates that donor/acceptor pairs affording exciplexes can be formed within cationic metal complexes using counter-anions with donor nature, which opens a new avenue toward photo-active metal complexes with rich photophysical properties

Response of the persentation of dry biomass of sorghum to saline-alkali stress.

Note: Values represent means±S.E. Values at each treatment group followed by different letters are significantly different (P < 0.05).</p

Insights into the Dissociation Process and Binding Pattern of the BRCT7/8-PHF8 Complex

DNA topoisomerase 2-binding protein 1 (Topbp1) plays a crucial role in activating the ataxia-telangiectasia mutated and rad3-related (ATR) complex to initiate DNA damage repair responses. For this process to occur, it is necessary for PHF8 to dissociate from Topbp1. Topbp1 binds to the acidic patch sequence (APS) of PHF8 through its C-terminal BRCT7/8 domain, and disrupting this interaction could be a promising strategy for cancer treatment. To investigate the dissociation process and binding pattern of BRCT7/8-PHF8, we employed enhanced sampling techniques, such as steered molecular dynamics (SMD) simulations and accelerated molecular dynamics (aMD) simulations, along with self-organizing maps (SOM) and time-resolved force distribution analysis (TRFDA) methodologies. Our results demonstrate that the dissociation of PHF8 from BRCT7/8 starts from the N-terminus, leading to the unfolding of the N-terminal helix. Additionally, we identified critical residues that play a pivotal role in this dissociation process. These findings provide valuable insights into the disassociation of PHF8 from BRCT7/8, which could potentially guide the development of novel drugs targeting Topbp1 for cancer therapy