1,456 research outputs found

    Low-energy behavior of spin-liquid electron spectral functions

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    We calculate the electron spectral function for a spin-liquid with a spinon Fermi surface and a Dirac spin-liquid. Calculations are based upon the slave-rotor mean-field theory. We consider the effect of gauge fluctuations using a simple model and find the behavior is not strongly modified. The results, distinct from conventional Mott insulator or band theory predictions, suggest that measuring the spectral function e.g. via ARPES could help in the experimental verification and characterization of spin liquids.Comment: 7 pages, 7 figure

    An Evaluation And An Interpretation of The Poetry Magazine And Its Influence On The Trend of American Poetry.

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    The purpose of this thesis is to interpret and evaluate the poetry magazine, and to show how it has influenced and is influencing the trend of American poetry

    Implementing Student-Produced Video Projects in Language Courses

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    Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer

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    <p>Abstract</p> <p>Background</p> <p>Abnormal amplification/expression of HER-2/<it>neu </it>oncogene has been causally linked with tumorigenesis and metastasis in breast cancer and associated with shortened overall survival of patients. Recently, heat shock protein 27 (Hsp27) was reported to be highly expressed in HER-2/<it>neu </it>positive tumors and cell lines. However, putative functional links between phosphorylation of Hsp27 with HER-2/<it>neu </it>status and other clinicopathological features remain to be elucidated.</p> <p>Results</p> <p>Comparative phosphoproteomic studies of HER-2/<it>neu </it>positive and -negative breast tumors revealed that Hsp27, one of the identified phosphoproteins, was highly phosphorylated in HER-2/<it>neu </it>positive tumors. The extent of Hsp27 phosphorylation at its Ser<sup>15</sup>, Ser<sup>78 </sup>and Ser<sup>82 </sup>residues were further evaluated with site-specific antibodies in tumor samples by tissue lysate array- and tissue microarray-based analyses, and in the BT474 breast cancer cell line treated with heregulin α1 (HRG α1) or the p38 MAPK inhibitor, SB203580. The tissue lysate array study indicated that only the level of pSer<sup>78 </sup>in HER-2/<it>neu </it>positive tumors was more than 2-fold that in HER-2/<it>neu </it>negative tumors. Treatment of BT474 cells with HRG α1 and SB203580 indicated that Ser<sup>78 </sup>phosphorylation was mainly regulated by the HER-2/<it>neu</it>-p38 MAPK pathway. Immunohistochemical staining of sections from a tissue microarray with 97 breast tumors showed that positive staining of pSer<sup>78 </sup>significantly correlated with HER-2/<it>neu </it>(<it>p </it>= 0.004) and lymph node positivity (<it>p </it>= 0.026).</p> <p>Conclusion</p> <p>This investigation demonstrated the significant correlation of enhanced phosphorylation of the Ser<sup>78 </sup>residue of Hsp27 with HER-2/<it>neu </it>and lymph node positivity in breast cancer.</p

    Leveraging Old Knowledge to Continually Learn New Classes in Medical Images

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    Class-incremental continual learning is a core step towards developing artificial intelligence systems that can continuously adapt to changes in the environment by learning new concepts without forgetting those previously learned. This is especially needed in the medical domain where continually learning from new incoming data is required to classify an expanded set of diseases. In this work, we focus on how old knowledge can be leveraged to learn new classes without catastrophic forgetting. We propose a framework that comprises of two main components: (1) a dynamic architecture with expanding representations to preserve previously learned features and accommodate new features; and (2) a training procedure alternating between two objectives to balance the learning of new features while maintaining the model's performance on old classes. Experiment results on multiple medical datasets show that our solution is able to achieve superior performance over state-of-the-art baselines in terms of class accuracy and forgetting.Comment: Accepted to AAAI2

    Issues and Trends in Collection Development for East Asian Legal Materials

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    The authors delineate the general policy and guidelines for developing foreign and transnational law collections in U.S. law libraries, and they analyze factors that shape East Asian collections, such as law libraries' preservation and digitization efforts and their related cost-efficiency, and the availability and quality of English translations. The authors then discuss the main sources for Korean, Japanese, and Chinese law

    Propuesta de servicios que brindará una consultora de comunicación digital en la ciudad de Chiclayo

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    El presente trabajo de investigación titulado “Propuesta de servicios que brindará una consultora de Comunicación digital en la ciudad de Chiclayo”, busca conocer el medio actual en el que se desenvuelven las empresas chiclayanas, y qué plataformas digitales son las que más utilizan. De esta manera se planteó los servicios que puede brindar una Consultora de Comunicación Digital en nuestra ciudad. Así mismo, se reforzó el concepto de las consultoras con entrevistas a cinco expertos, que explicaron la importancia de estas en el medio actual

    Gay community periodic survey: Melbourne 2015

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    This study finds that HIV testing by gay and bisexual men in Melbourne continues to increase. Executive summary The Melbourne Gay Community Periodic Survey is a cross-sectional survey of gay and homosexually active men recruited at a range of gay community sites in Melbourne. The major aim of the survey is to provide data on sexual, drug use, and testing practices related to the transmission of HIV and other sexually transmissible infections (STIs) among gay men. The most recent survey, the seventeenth in Melbourne, recruited a total of 3,006 men in January 2015. The majority of these men (n=2,429, 81%) were recruited using face-to-face recruitment by trained staff at gay social venues (e.g. bars and community organisations), sex-on-premises venues, sexual health clinics, and the Midsumma Carnival. The remaining 577 men (19%) participated through an online version of the survey. Online recruitment was conducted for the first time in 2015 through the social networking site Facebook. Men were directed to a website with an online version of the GCPS questionnaire (http://gcpsonline.net). The advertisements were targeted to all men aged 16 and above who were located in Victoria and indicated in their Facebook profile that they were ‘interested’ in men. From its start in 1998, the project has been funded by the Victorian Department of Health and supported by the Victorian AIDS Council and Living Positive Victoria. The Centre for Social Research in Health coordinates the survey, with support from the Kirby Institute. The overall response rate for the 2015 survey was 77%. The data presented in this report are from the period 2011 to 2015. Since 2011, there have been significant decreases in the proportions of men recruited at sexual health clinics, social venues, and the Midsumma Carnival. The proportion of men recruited from sex-on-premises venues has remained stable over time. The online sample was analysed before we incorporated it into the survey database. There were a number of differences between men recruited online and men recruited through venues and events. Men in the online sample were younger and were more likely to be born in Australia. Men in the online sample were also less likely to report testing for HIV in the 12 months prior to the survey and were more likely to report that they were HIV-negative. Compared to men recruited through physical venues, men recruited through online survey were more likely to be in a monogamous relationship and have condomless anal intercourse with their regular partner. They were also more likely to report condomless anal intercourse with casual partners and were less likely to know that PEP was available. The online and offline samples reported similar rates of STI testing and drug use. However, despite these differences, when we merged the online and offline samples, the majority of key indicators did not appear to be affected by the change in sampling methods. We have therefore incorporated the online sample into the combined database and the reporting of trends. We will, however, continue to monitor the impact of online recruitment on the sample over time
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