41 research outputs found

    A Mandatory Spay/Neuter Ordinance in San Francisco: The Solution to San Francisco’s Other Homeless Problem

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    This Capstone explains the dog overpopulation problem in San Francisco where the increase in dog impoundments and animal cruelty cases, particularly ones involving dogs, has been straining its Department of Animal Care & Control‚Äôs already limited resources. At least 33 local governments around the United States have implemented mandatory spay/neuter laws for all dogs as a way to curb dog overpopulation. This Capstone argues for San Francisco to adopt a similar mandatory spay/neuter law, in which all dogs over the age of six months must be spayed or neutered, with certain exceptions. This will relieve the strain on Animal Care & Control, save the City money, and decrease pain, suffering, and even death among San Francisco‚Äôs dog population. Not only is spaying and neutering crucial to reducing the population of unwanted dogs, but it also has many health, behavioral, and societal benefits. This Capstone analyzes the arguments for and against mandatory spay/neuter laws and ultimately argues that such laws should be mandatory. It provides an analysis of shelter data from two municipalities‚ÄĒClark County, Nevada, and Los Angeles County, California‚ÄĒthat have implemented mandatory spay/neuter laws, which reveals that recent dog intake and euthanasia rates are the lowest they have been in the past two decades, indicating that these laws are successful at reducing the unwanted dog population. This Capstone then outlines details of a mandatory spay/neuter law that would be ideal for San Francisco

    Synthesis and crystal structure of chalcogenide cluster compound

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    Three new cluster compounds were synthesized from Hg(EPh)2 (E = Se, Te; Ph = phenyl) in organic solvents. Two of these compounds, [Hg2Cl2(SePh)2(PCy3)2], (1), and [Hg2Br2(SePh)2(PCy3)2], (2), were prepared by reaction of Hg(SePh)2, HgX2 (X = Cl, Br) and tricyclohexylphosphine, PCy3, in dimethylformamide. The reaction of Hg(TePh)2 with HgBr2 in tetrahydrofuran using triphenylphosphine or 2,2’-bipyridine as co-ligands gave the polymeric cluster [{Hg5Br3(TePh)7}n] (3), whose dissolution in dimethylsulfoxide yielded the cluster [Hg3Br3(TePh)3]·2dmso. The influence of different ligands, coordinating solvents and reaction stoichiometries on the formation of the title compounds is also discussed. All complexes were characterized by elemental analysis, thermogravimetric analysis and single crystal X-ray diffractometry

    Palladium(II) complexes with thiosemicarbazones: syntheses, characterization and cytotoxicity against breast cancer cells and anti-mycobacterium tuberculosis activity

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    Three PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3)‚ÄĘH2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3)‚ÄĘH2O, 3, where PPh3 = triphenylphosphine; Haptsc = 2-acetylpyridine-thiosemicarbazone; Hapmtsc = 2-acetylpyridine-N(4)-methyl-thiosemicarbazone and Happtsc = 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All complexes were characterized by elemental analysis, IR, UV-Vis, 1H and 31P{1H} NMR spectroscopies, and had their crystalline structures determined by X-ray diffractometry from single crystals. The monoanionic thiosemicarbazonate ligands act in a tridentate mode, binding to the metal through the pyridine nitrogen, the azomethine nitrogen and the sulfur atoms. The cytotoxic activity against the breast cancer cell line MDA-MB231 and the anti-Mycobacterium tuberculosis H37Rv ATCC 27294 activity were evaluated for the compounds. All PdII complexes were highly active against the studied cell line, presenting similar values of IC50, around 5 ¬Ķmol L-1, while the clinically applied antitumor agent cisplatin was inactive. The compounds show remarkable anti-M. tuberculosis activities, presenting MIC values comparable or better than some commercial anti-M tuberculosis drugs.FAPESPCAPESCNPqFINE

    Palladium(II) complexes with thiosemicarbazones: syntheses, characterization and cytotoxicity against breast cancer cells and Anti-Mycobacterium tuberculosis activity

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    Tr√™s complexos de PdII com tiossemicarbazonas N(4)-substitu√≠das foram preparados: [Pd(aptsc)(PPh3)](NO3) H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, e [Pd(apptsc)(PPh3)](NO3) H2O, 3, sendo PPh3 = trifenilfosfina; Haptsc = 2-acetilpyridina-tiossemicarbazona; Hapmtsc = 2-acetilpiridina-N(4)-metil-tiossemicarbazona e Happtsc = 2-acetilpiridina-N(4)-fenil-tiossemicarbazona. Os complexos foram caracterizados por an√°lise elementar, IR, UV-Vis, ¬ĻH e 31P{¬ĻH} NMR e tiveram suas estruturas cristalinas determinadas por difratometria de raios X em monocristal. Os ligantes tiossemicarbazonatos monoani√īnicos atuam de modo tridentado, ligando-se ao metal pelos √°tomos de nitrog√™nio pirid√≠nico, nitrog√™nio azomet√≠nico e enxofre. A atividade citot√≥xica frente √† linhagem de c√©lulas tumorais MDA-MB231 (tumor de mama) e a atividade anti-Mycobacterium tuberculosis H37Rv ATCC 27294 dos compostos foram investigadas. Os complexos de PdII mostraram-se altamente ativos contra as c√©lulas tumorais, com valores de IC50 em torno de 5 ¬Ķmol L-1, enquanto o agente antitumoral em uso cl√≠nico cisplatina mostrou-se inativo. Os compostos apresentaram atividade anti-M. tuberculosis significante, com valores de CIM compar√°veis ou melhores que aqueles referentes a alguns f√°rmacos usados clinicamente contra tuberculose.Three PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3) H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3) H2O, 3, where PPh3 = triphenylphosphine; Haptsc = 2-acetylpyridine-thiosemicarbazone; Hapmtsc = 2-acetylpyridine-N(4)-methyl-thiosemicarbazone and Happtsc = 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All complexes were characterized by elemental analysis, IR, UV-Vis, ¬ĻH and 31P{¬ĻH} NMR spectroscopies, and had their crystalline structures determined by X-ray diffractometry from single crystals. The monoanionic thiosemicarbazonate ligands act in a tridentate mode, binding to the metal through the pyridine nitrogen, the azomethine nitrogen and the sulfur atoms. The cytotoxic activity against the breast cancer cell line MDA-MB231 and the anti-Mycobacterium tuberculosis H37Rv ATCC 27294 activity were evaluated for the compounds. All PdII complexes were highly active against the studied cell line, presenting similar values of IC50, around 5 ¬Ķmol L-1, while the clinically applied antitumor agent cisplatin was inactive. The compounds show remarkable anti-M. tuberculosis activities, presenting MIC values comparable or better than some commercial anti-M tuberculosis drugs

    Crystal structure of cis-1-phenyl-8-(pyridin-2-ylmethyl)dibenzo[1,2-c:2,1-h]-2,14-dioxa-8-aza-1-borabicyclo[4.4.0]deca-3,8-diene

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    The title compound, C26H23BN2O2, was obtained as by product during synthetic attempts of a complexation reaction between the tripodal ligand H2L [N,N-bis(2-hydroxybenzyl)(pyridin-2-yl)methylamine] and manganese(III) acetate in the presence of NaBPh4. The isolated B-phenyl dioxazaborocine contains an N‚ÜíB dative bond with a cis conformation. In the crystal, C‚ÄĒH...O hydrogen bonds define chains parallel to the b-axis direction. A comparative analysis with other structurally related derivatives is also included, together with a rationalization of the unexpected production of this zwitterionic heterocycle

    A facile preparation of two new isostructural metal-organochalcogen clusters from simple starting materials: Sonochemical synthesis, X-ray structures and spectroscopic remarks

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    In this work, the formation and characterisation of two new isostructural metal-organochalcogen clusters from simple starting materials was investigated. A sonochemical synthesis was performed in a one-pot procedure without the isolation of synthetic intermediates. This methodology offers a new approach to prepare cluster compounds, and this experiment led to the formation of [(PhTe)(12)Hg-8(S)X-2 (Py)(2)]center dot Py (X = Br, I; Py = Pyridine) in good yield. the X-ray analyses reveal that the framework of the clusters contains a similar [Hg-8(mu(4)-S)Te-12] core as the central unit. the sulphur atom present in the core of both structures has a tetrahedral coordination geometry achieved by four S-Hg(II) bonds. the complete characterisation of the synthesised materials also includes elemental analyses, IR spectroscopy and UV-Vis absorption data. (C) 2012 Elsevier B. V. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FINEP (Finaciadora de Estudos e Projetos)FUNDECT (Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado do Mato Grosso do Sul)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UFGDFundacao Univ Fed Grande Dourados, Lab Sintese & Caracterizacao Mol, BR-79804970 Dourados, MS, BrazilUniversidade Federal de São Paulo, Dept Quim, BR-09972270 Diadema, SP, BrazilUniv Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, BrazilUniv Fed Mato Grosso do Sul, Grp Opt & Foton, BR-79070900 Campo Grande, MS, BrazilUniversidade Federal de São Paulo, Dept Quim, BR-09972270 Diadema, SP, BrazilWeb of Scienc

    Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal

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    This study describes the synthesis, crystal structure and antioxidant activity of manganese(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en) (H2O)2]Cl 4H2O, [Mn(pyr2en)(H2O)(CH3OH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3] 4H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values in the range of 1.22?2.15 lM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value.Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Rosario. Instituto de Qu√≠mica Rosario; ArgentinaFil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Rosario. Instituto de Qu√≠mica Rosario; ArgentinaFil: Ledesma, Gabriela Nanci. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Rosario. Instituto de Qu√≠mica Rosario; ArgentinaFil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Rosario. Instituto de Qu√≠mica Rosario; ArgentinaFil: Back, Davi Fernando. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Materiais Inorg√Ęnicos; BrasilFil: Lang, Ernesto S.. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Materiais Inorg√Ęnicos; BrasilFil: Rossini Kopp, Cristi√©li. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Materiais Inorg√Ęnicos; BrasilFil: Ebani, Patr√≠cia. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Materiais Inorg√Ęnicos; BrasilFil: Brum Pereira, Mateus. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Materiais Inorg√Ęnicos; BrasilFil: Giacomelli, Cristiano. Universidade Federal de Santa Maria. Departamento de Qu√≠mica. Laborat√≥rio de Pol√≠meros e Col√≥ides; BrasilFil: Piquini, Paulo Cesar. Universidade Federal de Santa Maria. Departamento de F√≠sica; Brasi
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