279 research outputs found

    New late-time constraints on f(R)f(R) gravity

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    Modification of general relativity (GR) inspired by theories like f(R)f(R) gravity is among the most popular ones to explain the late-time acceleration of the Universe as an alternative to the Λ\LambdaCDM model. In this work, we use the state-of-the-art BAO+BBN data and the most recent Type Ia supernovae (SNe Ia) sample namely PantheonPlus, including the Cepheid host distances and covariance from SH0ES samples, to robustly constrain the f(R)f(R) gravity framework via two of the most popular f(R)f(R) models in literature, namely, the Hu-Sawicki and Starobinsky models. Additionally, we consider how the time variation of the Newton's gravitational constant affects the supernovae distance modulus relation. We find a minor evidence for f(R)f(R) gravity under the Hu-Sawicki dynamics from BAO+BBN and BAO+BBN+uncalibrated supernovae joint analysis, but the inclusion of Cepheid host distances, makes the model compatible with GR. Further, we notice tendency of this model to relax the H0H_0 tension. In general, in all the analyses carried out in this study with the late time probes, we find both the f(R)f(R) models to be consistent with GR at 95\% CL.Comment: 9 pages, 3 figures, 1 table, matches the version published in Physics of Dark Univers

    Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans.

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    UnlabelledMany symbiotic gut bacteria possess the ability to degrade multiple polysaccharides, thereby providing nutritional advantages to their hosts. Like microorganisms adapted to other complex nutrient environments, gut symbionts give different metabolic priorities to substrates present in mixtures. We investigated the responses of Bacteroides thetaiotaomicron, a common human intestinal bacterium that metabolizes more than a dozen different polysaccharides, including the O-linked glycans that are abundant in secreted mucin. Experiments in which mucin glycans were presented simultaneously with other carbohydrates show that degradation of these host carbohydrates is consistently repressed in the presence of alternative substrates, even by B. thetaiotaomicron previously acclimated to growth in pure mucin glycans. Experiments with media containing systematically varied carbohydrate cues and genetic mutants reveal that transcriptional repression of genes involved in mucin glycan metabolism is imposed by simple sugars and, in one example that was tested, is mediated through a small intergenic region in a transcript-autonomous fashion. Repression of mucin glycan-responsive gene clusters in two other human gut bacteria, Bacteroides massiliensis and Bacteroides fragilis, exhibited variable and sometimes reciprocal responses compared to those of B. thetaiotaomicron, revealing that these symbionts vary in their preference for mucin glycans and that these differences occur at the level of controlling individual gene clusters. Our results reveal that sensing and metabolic triaging of glycans are complex processes that vary among species, underscoring the idea that these phenomena are likely to be hidden drivers of microbiota community dynamics and may dictate which microorganisms preferentially commit to various niches in a constantly changing nutritional environment.ImportanceHuman intestinal microorganisms impact many aspects of health and disease, including digestion and the propensity to develop disorders such as inflammation and colon cancer. Complex carbohydrates are a major component of the intestinal habitat, and numerous species have evolved and refined strategies to compete for these coveted nutrients. Our findings reveal that individual bacteria exhibit different preferences for carbohydrates emanating from host diet and mucosal secretions and that some of these prioritization strategies are opposite to one another. Thus, we reveal new aspects of how individual bacteria, some with otherwise similar metabolic potential, partition to "preferred niches" in the complex gut ecosystem, which has important and immediate implications for understanding and predicting the behavioral dynamics of this community

    Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

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    This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

    Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation