Critical doping for the onset of a two-band superconducting ground state in SrTiO3−δ_{3-\delta}

In doped SrTiO$_{3}$ superconductivity persists down to an exceptionally low concentration of mobile electrons. This restricts the relevant energy window and possible pairing scenarios. We present a study of quantum oscillations and superconducting transition temperature, $T_{c}$ as the carrier density is tuned from $10^{17}$ to $10^{20}$ $cm^{-3}$ and identify two critical doping levels corresponding to the filling thresholds of the upper bands. At the first critical doping, which separates the single-band and the two-band superconducting regimes in oxygen-deficient samples, the steady increase of T$_{c}$ with carrier concentration suddenly stops. Near this doping level, the energy dispersion in the lowest band displays a downward deviation from parabolic behavior. The results impose new constraints for microscopic pairing scenarios.Comment: 5 pages of main article and 4 pages of supplemen

Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome

Introduction: Sepsis is still a leading cause of morbidity and mortality, even in modern times, and thrombocytopenia has been closely associated with unfavorable disease outcome. Decreases in mitochondrial membrane potential (depolarization) were found in different tissues during sepsis. Previous work suggests that mitochondrial dysfunction of platelets correlates with clinical disease activity in sepsis. However, platelet mitochondrial membrane potential (Mmp) has not been investigated in a clinical follow-up design and not with regard to disease outcome. Methods: In this study, platelet mitochondrial membrane depolarization was assessed by means of a fluorescent Mmp-Index with flow cytometry in 26 patients with sepsis compared with control patients. Platelet Mmp-Index on admission was correlated with the clinical disease scores Acute Physiology and Chronic Health Evaluation Score II (APACHE II), Sequential Organ Failure Score (SOFA), and Simplified Acute Physiology Score II (SAPS II). Finally, platelet Mmp-Index on admission and follow-up were compared in the group of sepsis survivors and nonsurvivors. Expression of the prosurvival protein Bcl-xL in platelets was quantified by immunoblotting. Results: Platelet mitochondrial membrane depolarization correlated significantly with the simultaneously assessed clinical disease severity by APACHE II (r = -0.867; P < 0.0001), SOFA (r = -0.857; P < 0.0001), and SAPS II score (r = -0.839; P < 0.0001). Patients with severe sepsis showed a significant reduction in platelet Mmp-Index compared with sepsis without organ failure (0.18 (0.12 to 0.25) versus 0.79 (0.49 to 0.85), P < 0.0006) or with the control group (0.18 (0.12 to 0.25) versus 0.89 (0.68 to 1.00), P < 0.0001). Platelet Mmp-Index remained persistently low in sepsis nonsurvivors (0.269 (0.230 to 0.305)), whereas we observed recovery of platelet Mmp-Index in the survivor group (0.9 (0.713 to 1.017)). Furthermore, the level of prosurvival protein Bcl-xL decreased in platelets during severe sepsis. Conclusion: In this study, we demonstrated that mitochondrial membrane depolarization in platelets correlates with clinical disease severity in patients with sepsis during the disease course and may be a valuable adjunct parameter to aid in the assessment of disease severity, risk stratification, and clinical outcome

100 Gb/s Data Link Layer - from a Simulation to FPGA Implementation, Journal of Telecommunications and Information Technology

In this paper, a simulation and hardware implementation of a data link layer for 100 Gb/s terahertz wireless communications is presented. In this solution the overhead of protocols and coding should be reduced to a minimum. This is especially important for high-speed networks, where a small degradation of efficiency will lower the user data throughput by several gigabytes per second. The following aspects are explained: an acknowledge frame compression, the optimal frame segmentation and aggregation, Reed-Solomon forward error correction, an algorithm to control the transmitted data redundancy (link adaptation), and FPGA implementation of a demonstrator. The most important conclusion is that changing the segment size influences the uncoded transmissions mostly, and the FPGA memory footprint can be significantly reduced when the hybrid automatic repeat request type II is replaced by the type I with a link adaptation. Additionally, an algorithm for controlling the Reed-Solomon redundancy is presented. Hardware implementation is demonstrated, and the device achieves net data rate of 97 Gb/s

A Stop Codon in Xeroderma Pigmentosum Group C Families in Turkey and Italy: Molecular Genetic Evidence for a Common Ancestor

Xeroderma pigmentosum family G from Van, Turkey had two severely affected children: a son with multiple skin cancers who died at age 10 (XP67TMA), and an 8 y old daughter who began developing skin cancer before 3 y of age (XP68TMA). XP67TMA and XP68TMA cells were hypersensitive to killing by ultraviolet and the post-ultraviolet DNA repair level was 12–16% of normal. Host cell reactivation of an ultraviolet-treated reporter plasmid cotransfected with a vector expressing wild-type XPC cDNA assigned XP67TMA to xeroderma pigmentosum complementation group C. The XPC mRNA level was markedly reduced. Sequencing of the 3.5 kb XPC cDNA from XP67TMA showed a C–T mutation in XPC exon 8 at base pair 1840. This mutation converts the CGA codon of arginine at amino acid 579 to a UGA stop codon resulting in marked truncation of the 940 amino acid xeroderma pigmentosum C protein. Restriction fragment length polymorphism analysis of XPC exon 8 DNA in XP67TMA and XP68TMA showed that both affected children had a homozygous mutation and that both parents had heterozygous normal and mutated sequences at the same position consistent with a history of consanguinity in the family. The mutated allele also contained two XPC single nucleotide polymorphisms. The same mutated XPC allele was reported in an Italian family. Studies of 19 microsatellite markers flanking the XPC gene on chromosome 3 suggest that the XPC allele passed between Italy and Turkey approximately 300–500 y ago. This XPC allele containing a nonsense mutation is associated with severe clinical disease with multiple skin cancers and early death

Demystifying the coronal line region of active galactic nuclei: spatially resolved spectroscopy with HST

We present an analysis of STIS/HST optical spectra of a sample of ten Seyfert galaxies aimed at studying the structure and physical properties of the coronal-line region (CLR). The high-spatial resolution provided by STIS allowed us to resolve the CLR and obtain key information about the kinematics of the coronal-line gas, measure directly its spatial scale, and study the mechanisms that drive the high-ionisation lines. We find CLRs extending from just a few parsecs (~10 pc) up to 230 pc in radius, consistent with the bulk of the coronal lines (CLs) originating between the BLR and NLR, and extending into the NLR in the case of [FeVII] and [NeV] lines. The CL profiles strongly vary with the distance to the nucleus. We observed line splitting in the core of some of the galaxies. Line peak shifts, both red- and blue-shifts, typically reached 500 km/s, and even higher velocities (1000 km/s) in some of the galaxies. In general, CLs follow the same pattern of rotation curves as low-ionisation lines like [OIII]. From a direct comparison between the radio and the CL emission we find that neither the strength nor the kinematics of the CLs scale in any obvious and strong way with the radio jets. Moreover, the similarity of the flux distributions and kinematics of the CLs and low-ionisation lines, the low temperatures derived for the gas, and the success of photoionisation models to reproduce, within a factor of few, the observed line ratios, point towards photoionisation as the main driving mechanism of CLs.Comment: Accepted for publication in MNRAS. 27 pages, 21 figures, 4 table

Optical--to--X-ray emission in low-absorption AGN: Results from the Swift-BAT 9 month catalogue

(Abridged) We present simultaneous optical--to--X-ray spectral energy distributions (SEDs) from Swift's X-ray and UV--optical telescopes (XRT and UVOT) for a well-selected sample of 26 low-redshift (z<0.1) AGN from the Swift/BAT 9-month catalogue, the largest well-studied, hard X-ray selected survey of local AGN to date. Our subsample consists of AGN with low intrinsic X-ray absorption (N_H<10^22 cm^-2) and minimal spectral complexity, to more accurately recover the intrinsic accretion luminosity in these sources. We perform a correction for host galaxy contamination in all available UVOT filter images to recover the intrinsic AGN emission, and estimate intrinsic dust extinction from the resultant nuclear SEDs. Black hole mass estimates are determined from the host-galaxy 2MASS K-band bulge luminosity. Accretion rates determined from our SEDs are on average low (Eddington ratios <~ 0.1) and hard X-ray bolometric corrections cluster at ~10-20, in contrast with the higher values seen for quasars. An average SED for the 22 low accretion rate (Eddington ratio < 0.1) objects is presented, with and without correction for intrinsic extinction. We do not find a correlation of optical--to--X-ray spectral index with Eddington ratio, regardless of the optical reference wavelength chosen for defining the spectral index. The low accretion rates and bolometric corrections found for this representative low-redshift sample are of particular importance for studies of AGN accretion history.Comment: 25 pages, 22 figures, 4 tables, accepted for publication in MNRA

Observing and modeling the dynamic atmosphere of the low mass-loss C-star R Sculptoris at high angular resolution

We study the circumstellar environment of the carbon-rich star R Scl using the near- and mid-infrared high spatial resolution observations from the ESO-VLTI instruments VINCI and MIDI. These observations aim at increasing our knowledge of the dynamic processes in play within the very close circumstellar environment where the mass loss of AGB stars is initiated. Data are interpreted using a self-consistent dynamic model. Interferometric observations do not show any significant variability effect at the 16 m baseline between phases 0.17 and 0.23 in the K band, and for both the 15 m baseline between phases 0.66 and 0.97 and the 31 m baseline between phases 0.90 and 0.97 in the N band. We find fairly good agreement between the dynamic model and the spectrophotometric data from 0.4 to 25 $\mu$m. The model agrees well with the time-dependent flux data at 8.5 $\mu$m, whereas it is too faint at 11.3 and 12.5 $\mu$m. The VINCI visibilities are reproduced well, meaning that the extension of the model is suitable in the K-band. In the mid-infrared, the model has the proper extension to reveal molecular structures of C2H2 and HCN located above the stellar photosphere. However, the windless model used is not able to reproduce the more extended and dense dusty environment. Among the different explanations for the discrepancy between the model and the measurements, the strong nonequilibrium process of dust formation is one of the most probable. The complete dynamic coupling of gas and dust and the approximation of grain opacities with the small-particle limit in the dynamic calculation could also contribute to the difference between the model and the data

Xeroderma Pigmentosum Group C Splice Mutation Associated with Autism and Hypoglycinemia

A 4 y old boy of Korean ancestry had xeroderma pigmentosum (XP) with sun sensitivity, multiple cutaneous neoplasms, and inability to speak. Neurologic examination revealed hyperactivity and autistic features without typical XP neurologic abnormalities. Cultured skin fibroblasts (XP22BE) showed decreased post-UV survival, reduced post-UV plasmid host cell reactivation and defective DNA repair (16% of normal unscheduled DNA synthesis in intact cells and undetectable excision repair in a cell free extract). In vitro and in vivo complementation assigned XP22BE to XP group C (XPC) and a markedly reduced level of XPC mRNA was found. Two XPC cDNA bands were identified. One band had a deletion of 161 bases comprising the entire exon 9, which resulted in premature termination of the mutant XPC mRNA. The larger band also had the same deletion of exon 9 but, in addition, had an insertion of 155 bases in its place (exon 9a), resulting in an in-frame XPC mRNA. Genomic DNA analysis revealed a T-->G mutation at the splice donor site of XPC exon 9, which markedly reduced its information content. The 155 base pair XPC exon 9a insertion was located in intron 9 and was flanked by strong splice donor and acceptor sequences. Analysis of the patient's blood showed persistently low levels of glycine (68 microM; NL, 125-318 microM). Normal glycine levels were maintained with oral glycine supplements and his hyperactivity diminished. These data provide evidence of an association of an XPC splice site mutation with autistic neurologic features and hypoglycinemia

Transverse-momentum-dependent Multiplicities of Charged Hadrons in Muon-Deuteron Deep Inelastic Scattering

A semi-inclusive measurement of charged hadron multiplicities in deep inelastic muon scattering off an isoscalar target was performed using data collected by the COMPASS Collaboration at CERN. The following kinematic domain is covered by the data: photon virtuality $Q^{2}>1$ (GeV/$c$)$^2$, invariant mass of the hadronic system $W > 5$ GeV/$c^2$, Bjorken scaling variable in the range $0.003 < x < 0.4$, fraction of the virtual photon energy carried by the hadron in the range $0.2 < z < 0.8$, square of the hadron transverse momentum with respect to the virtual photon direction in the range 0.02 (GeV/$c)^2 < P_{\rm{hT}}^{2} < 3$ (GeV/$c$)$^2$. The multiplicities are presented as a function of $P_{\rm{hT}}^{2}$ in three-dimensional bins of $x$, $Q^2$, $z$ and compared to previous semi-inclusive measurements. We explore the small-$P_{\rm{hT}}^{2}$ region, i.e. $P_{\rm{hT}}^{2} < 1$ (GeV/$c$)$^2$, where hadron transverse momenta are expected to arise from non-perturbative effects, and also the domain of larger $P_{\rm{hT}}^{2}$, where contributions from higher-order perturbative QCD are expected to dominate. The multiplicities are fitted using a single-exponential function at small $P_{\rm{hT}}^{2}$ to study the dependence of the average transverse momentum $\langle P_{\rm{hT}}^{2}\rangle$ on $x$, $Q^2$ and $z$. The power-law behaviour of the multiplicities at large $P_{\rm{hT}}^{2}$ is investigated using various functional forms. The fits describe the data reasonably well over the full measured range.Comment: 28 pages, 20 figure

The central role of myostatin in skeletal muscle and whole body homeostasis

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It plays a key role in skeletal muscle homeostasis and has now been well described since its discovery. Myostatin is capable of inducing muscle atrophy via its inhibition of myoblast proliferation, increasing ubiquitin-proteasomal activity and downregulating activity of the IGF–Akt pathway. These well-recognized effects are seen in multiple atrophy causing situations, including injury, diseases such as cachexia, disuse and space flight, demonstrating the importance of the myostatin signalling mechanism. Based on this central role, significant work has been pursued to inhibit myostatin's actions in vivo. Importantly, several new studies have uncovered roles for myostatin distinct from skeletal muscle size. Myostatin has been suggested to play a role in cardiomyocyte homeostasis, glucose metabolism and adipocyte proliferation, all of which are examined in detail below. Based on these effects, myostatin inhibition has potential to be widely utilized in many Western diseases such as chronic obstructive pulmonary disease, type II diabetes and obesity. However, if myostatin inhibitors are to successfully translate from bench-top to bedside in the near future, awareness must be raised on these non-traditional effects of myostatin away from skeletal muscle. Indeed, further research into these novel areas is required