Occurrence and epidemiology of animal and human BoDV-1 infections.

Genetically, BoDV-1 variants segregate into five distinct clusters (represented by different colors in the phylogenetic tree). Each cluster appears to be bound to confined regions in Germany, Switzerland, and Austria, where the viruses are maintained in infected bicolored white-toothed shrews (C. leucodon) serving as their natural reservoir. Persistently infected reservoir hosts stay apparently healthy and maintain the infection chain by shedding infectious virus. Accidental BoDV-1 transmissions to horses, sheep, humans, and other mammals result in often fatal immune-mediated encephalitis. In striking contrast to the reservoir host, the virus is restricted to the central nervous system in these accidental dead-end hosts that, thus, do not contribute to the spread of the virus. BoDV-1, Borna disease virus 1.</p

MOESM1 of Investigations into the presence of nidoviruses in pythons

Additional file 1: Table S1. Comparison of the newly developed real-time RT-PCRs with the one published by Dervas et al. (positive samples). Table S2. Sequence identity between all in this study generated partial sequences. Figure S1. Genome organization of snake nidoviruses. Sequences marked in red were generated within this study

Diagnostic results of South African field samples.

<p>Diagnostic results of South African field samples.</p

Diagnostic results of archived field samples.

<p>Diagnostic results of archived field samples.</p

Sensitivity assessment based using various dilutions of rabid brain (Lab-ID: 20299, n.a. = non analysable).

<p>Sensitivity assessment based using various dilutions of rabid brain (Lab-ID: 20299, n.a. = non analysable).</p

Diagnostic results of experimentally infected raccoons for different parts of the brain^#.

<p>Diagnostic results of experimentally infected raccoons for different parts of the brain<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004776#t001fn001" target="_blank">^#</a>.</p

Additional file 1 of Search for polyoma-, herpes-, and bornaviruses in squirrels of the family Sciuridae

Additional file 1. PCR assays for detection of borna-, polyoma- and herpesviruses and mycoplasma

Additional file 7 of Search for polyoma-, herpes-, and bornaviruses in squirrels of the family Sciuridae

Additional file 7. Maximum clade credibility tree analysis of betaherpesviruses based on conserved amino acid blocks of the DPOL sequences. Phylogenetic relationships of betaherpesviruses, including classification of the novel viruses, based on conserved amino acid blocks of DPOL sequence. Branch support values displayed at the nodes correspond to their posterior probability. For further explanation see legend of Fig. 4

Additional file 5 of Search for polyoma-, herpes-, and bornaviruses in squirrels of the family Sciuridae

Additional file 5. Maximum likelihood tree analysis of polyomaviruses based on conserved amino acid blocks of the VP1 sequences. Phylogenetic relationships of polyomaviruses, including classification of the novel viruses, based on conserved amino acid blocks of VP1 sequence. Branch support values displayed at the nodes were assessed using Shimodaira-Hasagawa-like approximate likelihood ratio tests (SH-like aLRT). For further details see legend of Fig. 3

Additional file 11 of Search for polyoma-, herpes-, and bornaviruses in squirrels of the family Sciuridae

Additional file 11. Maximum likelihood tree analysis of gammaherpesviruses based on conserved amino acid blocks of the gB sequences. Phylogenetic relationships of gammaherpesviruses, including classification of the novel viruses, based on conserved amino acid blocks of gB sequence. Branch support values displayed at the nodes were assessed using Shimodaira-Hasagawa-like approximate likelihood ratio tests (SH-like aLRT). For further explanation see legend of Fig. 5