EVALUATION OF HORMONAL AND METABOLIC PARAMETERS, ALONG WITH CARDIOVASCULAR RISK FACTORS IN WOMEN WITH NON-ALCOHOLIC FATTY LIVER DISEASE COMBINED WITH SUBCLINICAL HYPOTHYROIDISM DEPENDING ON AGE

Patients with NAFLD (non-alcoholic fatty liver disease) and subclinical hypothyroidism are at risk of cardiovascular complications that cause cardiometabolic changes, thus enabling to broaden our understanding of the cardiovascular events risk in a comorbid patient. The aim: The study of hormonal and metabolic indicators and cardiovascular risk factors in women from NAFLD combined with SH (subclinical hypothyroidism) depending on the age. Materials and methods: 128 patients with NAFLD were studied, which were divided into 2 groups: І group – patients with NAFLD and level of thyroid-stimulating hormone (TSH) – 4 to 10 mIU/mL (n=45), ІІ group - patients with NAFLD and level of TSH >10 mIU/mL (n=49). The control group consisted of 34 NAFLD patients without SH. Depending on the level of TSH and age, degree of cardiovascular risk, indicators of carbohydrate and lipid metabolism, as well as the indicators that reflect ED were evaluated. Results: Comparison of metabolic parameters in two groups showed a significant difference (p<0.01 between indicators depending on the TSH level, where patients were below 50 years of age: HbA1c, LDL cholesterol, HDL cholesterol, gamma-glutamyltranspeptidase (GGTP). The levels of CDEC (circulating desquamated endothelial cells), VEGF (vascular endothelial growth factor), CRP (C-reactive protein) and TNF-α (tumor necrosis factor-α) were dependent not only on TSH, but also on age. Significant differences (p=0.001) were obtained in patients aged ≤ 50 years: CDEC; VEGF, CRP; TNF-α. Conclusions: Patients from NAFLD combined with SH have hormonal-metabolic disorders, and their degree depends on the TSH level. Early cardiometabolic changes in women are formed already at the age under 50 years, which indicates the formation of early atherosclerotic vascular change

Automatic Translation of Hate Speech to Non-hate Speech in Social Media Texts

In this paper, we investigate the issue of hate speech by presenting a novel task of translating hate speech into non-hate speech text while preserving its meaning. As a case study, we use Spanish texts. We provide a dataset and several baselines as a starting point for further research in the task. We evaluated our baseline results using multiple metrics, including BLEU scores. The aim of this study is to contribute to the development of more effective methods for reducing the spread of hate speech in online communities

First Attempt at Building Parallel Corpora for Machine Translation of Northeast India's Very Low-Resource Languages

This paper presents the creation of initial bilingual corpora for thirteen very low-resource languages of India, all from Northeast India. It also presents the results of initial translation efforts in these languages. It creates the first-ever parallel corpora for these languages and provides initial benchmark neural machine translation results for these languages. We intend to extend these corpora to include a large number of low-resource Indian languages and integrate the effort with our prior work with African and American-Indian languages to create corpora covering a large number of languages from across the world.Comment: Accepted to ICON 202

A Conceptual Rationale for a Contemporary Unified Code of Ethics in Ukraine

The globalization of psychology-counseling in Ukraine began about 30 years ago. Since the establishment of applied psychology in the early 1990s, the pro- fession is still forming its standards of education, training, and standards of care. Ukraine legislation has actively developed in the last ten years, especially given the needs presented with the Ukrainian-Russian war. Ukrainian psycholo- gists-counselors address the needs of hundreds of thousands of recent veter- ans and displaced people that fled occupied territories. Therefore, the stand- ards of care and the need for an updated unified ethical code are actively dis- cussed in Ukraine at present. The purpose of this paper was to discuss universal principles of ethics that could be contextualized to update the Ukrainian eth- ics code for psychological counseling. The authors apply social dominance the- ory and the contextual model of psychotherapy to illustrate ethical guiding prin- ciples that need to be considered in the developing code of ethics. Case study examples are provided to illustrate global ethical principles application with the cultural sensitivity and respect for the global environment. The paper concludes with concluding social implications to ethical practice within Ukraine and gui- dance for future research

Molecular structure of promoter-bound yeast TFIID.

Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promoter-bound yeast TFIID at a resolution better than 5 Å, except for a flexible domain. We position the crystal structures of several subunits and, in combination with cross-linking studies, describe the quaternary organization of TFIID. The compact tri lobed architecture is stabilized by a topologically closed Taf5-Taf6 tetramer. We confirm the unique subunit stoichiometry prevailing in TFIID and uncover a hexameric arrangement of Tafs containing a histone fold domain in the Twin lobe

Enhancing Translation for Indigenous Languages: Experiments with Multilingual Models

This paper describes CIC NLP's submission to the AmericasNLP 2023 Shared Task on machine translation systems for indigenous languages of the Americas. We present the system descriptions for three methods. We used two multilingual models, namely M2M-100 and mBART50, and one bilingual (one-to-one) -- Helsinki NLP Spanish-English translation model, and experimented with different transfer learning setups. We experimented with 11 languages from America and report the setups we used as well as the results we achieved. Overall, the mBART setup was able to improve upon the baseline for three out of the eleven languages.Comment: Accepted to Third Workshop on NLP for Indigenous Languages of the America

Development of technology of creams using hydrocolloids

The article presents a scientific study of the functional and technological properties of hydrocolloids, namely thickeners of polysaccharide nature, which are used as thickeners and stabilizers in dessert products. According to the monitoring of literature sources and the experience of manufacturers, the most commonly used thickeners of polysaccharide nature are carrageenan, locust bean gum, xanthan gum, pectin, starch, etc. However, each of these polysaccharides has both positive and negative sides, more polysaccharides are able to form dense gels, but with a high synergistic effect. Thickeners, such as k-carrageenan, low-esterified pectins, can form gels only in the presence of Са2+. There are also polysaccharides that form gels only at low temperatures and are not stable during external factors (temperature of sale and storage, mechanical impact, etc.). Therefore, the study was conducted on the combination of polysaccharides in order to obtain creams with an airy gel-like structure. It has been determined, that it is expedient to use the combination "xanthan gum 0.75 % – locust bean gum 0.5 %" to obtain crea

Influence of obesity on biological age in patients with arterial hypertension

Introduction: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension. Materials and methods: 116 patients (the age 35–65 years, women 62.3%) with stage 1–2 grade 1–2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock. Results: The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resista (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn’t find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA1c, FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05). Conclusions. Pathological weight gain associated with  the progression of metabolic disorders and accelerated ageing in patients with hypertension and low/moderate cardiovascular risk

Investigation of the effect of algorithms of positioning robots on their power and energy consumption

The paper is devoted to the study of motion algorithms that determine the power and energy consumption of process equipment and positioning robots, which are important factors affecting the environment and environmental safety of the technosphere. Based on the study of mathematical models of the degrees of mobility of the gantry robot drives, it is found that under the traditional laws of motion, a fairly significant peak in power consumption occurs at the end of acceleration. The paper shows that by separating in time the moments of the end of acceleration of different drives, it is possible to significantly reduce the maximum power of the robot. A comprehensive approach to the choice of an algorithm and laws of motion that provide an acceptable combination of energy consumption and maximum power consumption has been developed. The authors have shown that there are such laws of motion that ensure the constancy of power for the duration of the acceleration stage and its minimization. The relationship between the minimum instantaneous power and power consumption for such robots has been established. The results obtained can be used to optimize the operation algorithms of both of existing and newly +-robots