Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia

A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. We made a clinical diagnosis of invasive pulmonary aspergillosis (IPA) based on a consolidation in the right upper lung field on a chest radiograph as well as a high level of serum beta-D-glucan (with no evidence of tuberculosis and candidiasis). We changed her treatment from micafungin to voriconazole. Later, we discovered an air-crescent sign by CT scan that supported the diagnosis of IPA. Following voriconazole treatment, clinical symptoms ceased and abnormal chest shadows improved gradually and concurrently with a recovery of neutrophils. IPA must be considered in immunocompromised patients with pulmonary infiltrates who do not respond to broad-spectrum antibiotics. Serological tests and CT findings can aid in early diagnosis of IPA, which, along with treatment for IPA, will improve clinical outcomes.</p

Investigation of turbulence in reversed field pinch plasma by using microwave imaging reflectometry

Turbulence in the reversed field pinch (RFP) plasma has been investigated by using the microwave imaging reflectometry in the toroidal pinch experiment RX (TPE-RX). In conventional RFP plasma, the fluctuations are dominated by the intermittent blob-like structures. These structures are accompanied with the generation of magnetic field, the strong turbulence, and high nonlinear coupling among the high and low k modes. The pulsed poloidal current drive operation, which improves the plasma confinement significantly, suppresses the dynamo, the turbulence, and the blob-like structures.This work is supported by the NINS Imaging Science Project (Grant No. NIFS08KEIN0021), SOKENDAI (Grant No. NIFS08GLPP003), and the Budget for Nuclear Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan

Microwave Imaging Reflectometry Experiment in TPE-RX

Microwave imaging reflectometry (MIR) was developed in TPE-RX, one of the world’s largest reversed field pinch (RFP) devices. The system optics are made of aluminum mirrors, Teflon lenses, and Plexiglas plates in order to reduce size. In this system, frequencies are stabilized so that noise can be reduced using narrow bandpass filters. A 4×4 2-D mixer array and phase detection system have also been developed. With this system, density fluctuations in the high-Θ RFP plasma, pulsed poloidal current drive (PPCD) plasma, and quasi-single helicity(QSH) plasma are observed in TPE-RX. This is the first MIR experiment in an RFP device