226,388 research outputs found

    Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology.

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    The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain. Age-related changes in calcium levels and dynamics have the potential to increase the production and accumulation of both amyloid-beta peptide (Abeta) and tau pathologies in the AD brain, although these two pathologies themselves can induce calcium dyshomeostasis, particularly at synaptic membranes. This review discuses the evidence for a role for calcium dyshomeostasis in the initiation of pathology, as well as the evidence for these pathologies themselves disrupting normal calcium homeostasis, which lead to synaptic and neuronal dysfunction, synaptotoxicity and neuronal loss, underlying the dementia associated with the disease

    New identities involving q-Euler polynomials of higher order

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    In this paper we give new identities involving q-Euler polynomials of higher order.Comment: 11 page

    Modulation of the Curie Temperature in Ferromagnetic/Ferroelectric Hybrid Double Quantum Wells

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    We propose a ferromagnetic/ferroelectric hybrid double quantum well structure, and present an investigation of the Curie temperature (Tc) modulation in this quantum structure. The combined effects of applied electric fields and spontaneous electric polarization are considered for a system that consists of a Mn \delta-doped well, a barrier, and a p-type ferroelectric well. We calculate the change in the envelope functions of carriers at the lowest energy sub-band, resulting from applied electric fields and switching the dipole polarization. By reversing the depolarizing field, we can achieve two different ferromagnetic transition temperatures of the ferromagnetic quantum well in a fixed applied electric field. The Curie temperature strongly depends on the position of the Mn \delta-doped layer and the polarization strength of the ferroelectric well.Comment: 9 pages, 5 figures, to be published in Phys. Rev. B (2006) minor revision: One of the line types is changed in Fig.

    Surplus Angle and Sign-flipped Coulomb Force in Projectable Horava-Lifshitz Gravity

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    We obtain the static spherically symmetric vacuum solutions of Horava-Lifshitz gravity theory, imposing the detailed balance condition only in the UV limit. We find the solutions in two different coordinate systems, the Painlev\'e-Gullstrand coordinates and the Poincare coordinates, to examine the consequences of imposing the projectability condition. The solutions in two coordinate systems are distinct due to the non-relativistic nature of the HL gravity. In the Painleve-Gullstrand coordinates complying with the projectability condition, the solution involves an additional integration constant which yields surplus angle and implies attractive Coulomb force between same charges.Comment: 13 page