4,578 research outputs found
Dynamics of Information Packaging in Korean
This paper discusses deletion and movement operations in Korean from the perspective of information packaging, and claims that each operation is a systematic process of information packaging to generate the most optimized information structure. This paper argues that there is neither free word order nor free deletion in Korean. This paper explicitly illustrates that old arguments cannot stand still in information structure, but must undergo some kind of structural changes or deletion. This paper proposes a constraint on information packaging that covers both operations and gives an explanation of underlying motivation for them. It is also suggested to decompose each component of information structure into a feature complex. 1
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Work-Related Perceptions, Injuries, and Musculoskeletal Symptoms: Comparison Between U.S.-Educated and Foreign-Educated Nurses.
Immigrants account for a significant proportion of the nursing workforce in the United States (U.S.). Although different cultural backgrounds may affect immigrant nurses' perceptions of work and occupational health risks, little research has been conducted. Defining immigrant nurses as those who received initial nursing education in foreign countries, this study examined the differences in work-related perceptions and experiences of musculoskeletal (MS) symptoms and injuries between U.S.-educated and foreign-educated nurses. We analyzed data from a cross-sectional study using a statewide random sample of 419 California registered nurses. Foreign-educated nurses reported a more positive safety climate (p = .017) and perceived their jobs as less demanding (p = .008) than did U.S.-educated nurses. The prevalence of work-related MS symptoms was significantly lower in foreign-educated nurses than in U.S.-educated nurses (p = .044), but the difference was not significant in the multivariable analyses. Positive safety climate was significantly associated with a decreased risk of work-related MS symptoms and injuries, and this relationship was greater among U.S.-educated nurses than among foreign-educated nurses. Our findings suggest that immigrant nurses may have different perceptions about safety climate and job demand, which may modify their occupational health risks
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and may constitute a proportion of the mechanisms by which genetic variations cause individual differences or diseases. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases
Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster
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Extended Self-Concept and Brand-Related Responses in the Sensory Modality Context
Self-concept has been addressed as an important factor that influences consumer behavior. Fashion brands, in particular, are frequently used a way of expressing self to others. However, recent resurgence of research interests in self-concept focuses not on the self-concept per se, but on the relationship between the self-concept and brand-related behavior (Kirmani, 2009)
Differential gene expression in the visceral adipose-drived stromal cells from cancer patients and theiar interactions with human ovarian cancer cells
International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discoverry in Academics 2014 [DATE]: January 23(Thu)-24(Fri),2014, [Place]:Kanazawa Excel Hotel Tpkyu, Kanazawa, Japan, [Organizers]:Kanazawa Association of Tumor Biologists / Cancer Research Institute, Kanazawa Universit
The logic of regionalism: a comparative study of regionalism in Europe and Asia
Why do some states develop deeper regionalism while others do not? Comparing European and Asian regionalism, this study provides an alternative explanation of different types of regionalism and the national variations in regionalization since the mid 1980s. It defines regionalism as a strategy pursued by a state that desires to enhance its governability of the national economy when market authority outgrows state authority. The rise of regionalism in the neoliberal world economic order changes the balance between the states public power and the states market governability, consequently resulting in a political convergence toward a majoritarian political system based on individualism and delegative democracy. However, regionalism is realized in very distinctive patterns across different regions as the different historical paths of regional capitalism shape the state-society relationship and the states capability of governing the national economy.
European welfare states developed a deeper regionalism because they sought to impose a neoliberal economic transformation on their societies by shifting their economic priority of equality and economic policy making based on social concertation toward efficiency and the formation of an encompassing distributional coalition. In contrast, Asian developmental states prefer preserving national autonomy to relying on a formal regional institution to constrain states national authority because they are more capable of implementing the neoliberal economic transformation in terms of market governability and the formation of encompassing distributional coalitions
Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA). The concentration of histamine in synovial fluid (SF) and sera in patients with RA was measured using ELISA. After RA SF and peripheral blood (PB) CD14+ monocytes were treated with histamine, IL-17, IL-21 and IL-22, and a H4R antagonist (JNJ7777120), the gene expression H4R and RANKL was determined by real-time PCR. Osteoclastogenesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes cultured with histamine, Th17 cytokines and JNJ7777120. SF and serum concentration of histamine was higher in RA, compared with osteoarthritis and healthy controls. The expression of H4R was increased in PB monocytes in RA patients. Histamine, IL-6, IL-17, IL-21 and IL-22 induced the expression of H4R in monocytes. Histamine, IL-17, and IL-22 stimulated RANKL expression in RA monocytes and JNJ7777120 reduced the RANKL expression. Histamine and Th17 cytokines induced the osteoclast differentiation from monocytes and JNJ7777120 decreased the osteoclastogenesis. H4R mediates RANKL expression and osteoclast differentiation induced by histamine and Th17 cytokines. The blockage of H4R could be a new therapeutic modality for prevention of bone destruction in RA
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