Eccomi pronto : implementation of a Socio-Emotional Development curriculum in a South Korean elementary school

‘Eccomi Pronto’ (EP), an elementary school socio-emotional learning curriculum that was originally developed and evaluated in Italy was translated in Korean and implemented and evaluated in 4th grade classrooms of a primary school in South Korea. Qualitative data from teachers indicated that EP improved the self-reflection and selfdirection of students, resulted in pedagogically useful insights into the psychological functioning of students, and enhanced the quality of teacher-student interaction. However, statistically significant changes in students’ engaged, academic behavior (as measured by an 8-item survey) were not noted. Teachers reported that the core of the EP curriculum was appropriate for the South Korean educational context. Teachers also recommended modifications in the follow-up learning activities to make these activities more consistent with South Korean education practices.peer-reviewe

Comparison of CORSIKA and COSMOS simulations

Ultra-high-energy cosmic rays (UHECRs) refer to cosmic rays with energy above 10^{18} eV. UHECR experiments utilize simulations of extensive air shower to estimate the properties of UHECRs. The Telescope Array (TA) experiment employs the Monte Carlo codes of CORSIKA and COSMOS to obtain EAS simulations. In this paper, we compare the results of the simulations obtained from CORSIKA and COSMOS and report differences between them in terms of the longitudinal distribution, Xmax-value, calorimetric energy, and energy spectrum at ground.Comment: 4 pages, 6 figures, to appear in proceedings of UHECR2010 (AIP Conference Series

Content-aware kinetic scrolling for supporting web page navigation

Long documents are abundant on the web today, and are accessed in increasing numbers from touchscreen devices such as mobile phones and tablets. Navigating long documents with small screens can be challenging both physically and cognitively because they compel the user to scroll a great deal and to mentally filter for important content. To support navigation of long documents on touchscreen devices, we introduce content-aware kinetic scrolling, a novel scrolling technique that dynamically applies pseudo-haptic feedback in the form of friction around points of high interest within the page. This allows users to quickly find interesting content while exploring without further cluttering the limited visual space. To model degrees of interest (DOI) for a variety of existing web pages, we introduce social wear, a method for capturing DOI based on social signals that indicate collective user interest. Our preliminary evaluation shows that users pay attention to items with kinetic scrolling feedback during search, recognition, and skimming tasks.Quanta Computer (Firm)Samsung (Firm) (Fellowship

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo.

Aldosterone produces a multitude of effects in vivo, including promotion of postmyocardial infarction adverse cardiac remodeling and heart failure progression. It is produced and secreted by the adrenocortical zona glomerulosa (AZG) cells after angiotensin II (AngII) activation of AngII type 1 receptors (AT(1)Rs). Until now, the general consensus for AngII signaling to aldosterone production has been that it proceeds via activation of G(q/11)-proteins, to which the AT(1)R normally couples. Here, we describe a novel signaling pathway underlying this AT(1)R-dependent aldosterone production mediated by beta-arrestin-1 (betaarr1), a universal heptahelical receptor adapter/scaffolding protein. This pathway results in sustained ERK activation and subsequent up-regulation of steroidogenic acute regulatory protein, a steroid transport protein regulating aldosterone biosynthesis in AZG cells. Also, this betaarr1-mediated pathway appears capable of promoting aldosterone turnover independently of G protein activation, because treatment of AZG cells with SII, an AngII analog that induces betaarr, but not G protein coupling to the AT(1)R, recapitulates the effects of AngII on aldosterone production and secretion. In vivo, increased adrenal betaarr1 activity, by means of adrenal-targeted adenoviral-mediated gene delivery of a betaarr1 transgene, resulted in a marked elevation of circulating aldosterone levels in otherwise normal animals, suggesting that this adrenocortical betaarr1-mediated signaling pathway is operative, and promotes aldosterone production and secretion in vivo, as well. Thus, inhibition of adrenal betaarr1 activity on AT(1)Rs might be of therapeutic value in pathological conditions characterized and aggravated by hyperaldosteronism

Dynamic Biomechanical Characteristics of the Optic Nerve Head by OCT Imaging

Approximately 80 million people in the world were estimated to suffer from glaucoma in 2020. To date, lowering intraocular pressure (IOP) is the only clinical treatment to delay or prevent the development and progression of glaucomatous vision loss. However, many glaucoma patients have IOP in the normal range, while some people with abnormally high pressure do not develop neuropathy. This indicates that biomechanical responses of the optic nerve head (ONH) to changes in IOP can vary significantly among individuals. This study investigated acute IOP-induced compliance in the ONH via SDOCT imaging, using computer vision, and deep learning networks to improve understanding of the association the morphological changes with glaucomatous neuropathy. First, developing models demonstrating the relationship between IOP and morphological changes in the ONH of living eyes were performed. To separate the systematic variability induced by IOP from the stochastic variability due to pulsatile and eye motions, we proposed a normalized histogram-based image registration approach utilizing image spatial information. As a result, discontinuities of A-scans and the tilt of the central axis were reduced. To determine if IOP-induced strains are a metric of acute morphological changes in various anatomical ONH tissues, we assessed the repeatability of in vivo strain measurements. Strain variability across eyes was greater than variation iv across imaging sessions, indicating that intersession strains of each eye are repeatable. On the current testing platform, strain and IOP were measured separately by two different devices. We synchronized the two measurements based on their strong correlation with the cardiac cycle under controlled test conditions. Preliminary data depicting the relation between IOP and strain indicate that models could be built by the optimization process. Second, convolutional neural network (CNN) based OCT scan segmentation with improved robustness was developed by simulating multiple degradation types of clinical OCT imaging to measure morphological changes in the ONH tissues. Preliminary data indicates that when segmenting OCT scans acquired in clinical settings, the performance of the newly trained models is improved. It implies that the CNN-based OCT segmentation approach with improved robustness can be deployed in clinical settings

Designing Pedagogy For Existing Mathematics: Measurement Curriculum In A Language Immersion School

This project addressed the research question of how instruction in the multilingual classroom learning environment can be beneficial in a language immersion school? How should the first-year teacher start to deliver effectively for students in multicultural circumstances? This document created curriculum for the subject of measurement taught by a first-year language immersion school teacher and included appropriate teaching pedagogy according to students’ individual circumstance in second grade mathematics. The author has keenly researched current, various perspectives from teachers, parents, and students as well as other facts regarding language immersion schools. Where there are students of different educational backgrounds, the teacher should design a lesson depending on students’ learning styles; the lessons need to meet academic standards as well. Synthetically, all the research findings are scaffolded to create a measurement lesson plan that includes all the students’ learning aspects within their multicultural backgrounds

Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2), which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis and lung metastasis and induces apoptosis by increasing the intracellular mature form of cathepsin B, whereas BAG2 expression induces metastasis by blocking the auto-cleavage processing of pro-cathepsin B via interaction with the propeptide region. BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis. Collectively, our results uncover BAG2 as a regulator of the oncogenic function of pro-cathepsin B and a potential diagnostic and therapeutic target that may reduce the burden of metastatic breast cancer