170,953 research outputs found

    Domain-mediated interactions for protein subfamily identification

    Get PDF
    Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu

    Mott physics in 2p2p electron dioxygenyl magnet : O2_{2}MMF6_{6} (MM=Sb, Pt)

    Full text link
    We have investigated electronic structures and magnetic properties of O2_{2}MMF6_{6} (MM=Sb, Pt), which are composed of two building blocks of strongly correlated electrons: O2+_{2}^{+} dioxygenyls and MMF6_{6}^{-} octahedra, by employing the first-principles electronic structure band method. For O2_{2}SbF6_{6}, as a reference system of O2_{2}PtF6_{6}, we have shown that the Coulomb correlation of O(2pp) electrons drives the Mott insulating state. For O2_{2}PtF6_{6}, we have demonstrated that the Mott insulating state is induced by the combined effects of the Coulomb correlation of O(2pp) and Pt(5dd) electrons and the spin-orbit (SO) interaction of Pt(5dd) states. The role of the SO interaction in forming the Mott insulating state of O2_{2}PtF6_{6} is similar to the case of Sr2_{2}IrO4_{4} that is a prototype of a SO induced Mott system with Jeff=1/2_{eff}=1/2.Comment: 5 pages, 6 figure
    corecore