170,953 research outputs found
Domain-mediated interactions for protein subfamily identification
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu
Mott physics in electron dioxygenyl magnet : OF (=Sb, Pt)
We have investigated electronic structures and magnetic properties of
OF (=Sb, Pt), which are composed of two building blocks of
strongly correlated electrons: O dioxygenyls and F
octahedra, by employing the first-principles electronic structure band method.
For OSbF, as a reference system of OPtF, we have shown
that the Coulomb correlation of O(2) electrons drives the Mott insulating
state. For OPtF, we have demonstrated that the Mott insulating
state is induced by the combined effects of the Coulomb correlation of O(2)
and Pt(5) electrons and the spin-orbit (SO) interaction of Pt(5) states.
The role of the SO interaction in forming the Mott insulating state of
OPtF is similar to the case of SrIrO that is a
prototype of a SO induced Mott system with J.Comment: 5 pages, 6 figure
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