New and Old Results in Resultant Theory

Resultants are getting increasingly important in modern theoretical physics: they appear whenever one deals with non-linear (polynomial) equations, with non-quadratic forms or with non-Gaussian integrals. Being a subject of more than three-hundred-year research, resultants are of course rather well studied: a lot of explicit formulas, beautiful properties and intriguing relationships are known in this field. We present a brief overview of these results, including both recent and already classical. Emphasis is made on explicit formulas for resultants, which could be practically useful in a future physics research.Comment: 50 pages, 15 figure

Complication of Salmonella Bacteremia in a Case of Treated Fungal Endophthalmitis

This is to report a case of bacteremia caused by Salmonella typhi in a treated unilateral fungal endogenous endophthalmitis in an 18-year-old male from one of the South Asian countries. Microbiological and molecular investigations were carried out on the eviscerated material and routine blood culture was carried out. Direct examination of eviscerated material revealed the presence of fungal filaments. However, Salmonella typhi was isolated from both specimens, which was confirmed by Polymerase chain reaction targeting the 16SrRNA gene, sequencing, and random amplification of polymorphic DNA showed that they belonged to the same clone. The presence of Salmonella bacteremia in a treated unilateral fungal endophthalmitis, among young adult patients is rare and systemic symptoms should be investigated

Comparing inclination-dependent analyses of kilonova transients

The detection of the optical transient AT2017gfo proved that binary neutron star mergers are progenitors of kilonovae (KNe).Using a combination of numerical-relativity and radiative-transfer simulations, the community has developed sophisticated models for these transients for a wide portion of the expected parameter space. Using these simulations and surrogate models made from them, it has been possible to perform Bayesian inference of the observed signals to infer properties of the ejected matter. It has been pointed out that combining inclination constraints derived from the KN with gravitational-wavemeasurements increases the accuracy with which binary parameters can be estimated, in particular breaking the distance-inclination degeneracy from gravitational wave inference. To avoid bias from the unknown ejecta geometry, constraints on the inclination angle for AT2017gfo should be insensitive to the employed models. In this work, we compare different assumptions about the ejecta and radiative reprocesses used by the community and we investigate their impact on the parameter inference. While most inferred parameters agree, we find disagreement between posteriors for the inclination angle for different geometries that have been used in the current literature. According to our study, the inclusion of reprocessing of the photons between different ejecta types improves the modeling fits to AT2017gfo and, in some cases, affects the inferred constraints. Our study motivates the inclusion of large ~1-mag uncertainties in the KN models employed for Bayesian analysis to capture yet unknown systematics, especially when inferring inclination angles, although smaller uncertainties seem appropriate to capture model systematics for other intrinsic parameters. We can use this method to impose soft constraints on the ejecta geometry of the KN AT2017gfo

Phosphoproteomics of retinoblastoma:A pilot study identifies aberrant kinases

Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited signalling pathways. The dysregulation of protein phosphorylation in cancer provides clues about the affected signalling cascades in cancer. Phosphoproteomics is an ideal tool for the study of phosphorylation changes in proteins. Hence, global phosphoproteomics of retinoblastoma (RB) was carried out to identify signalling events associated with this cancer. Over 350 proteins showed differential phosphorylation in RB compared to control retina. Our study identified stress response proteins to be hyperphosphorylated in RB which included H2A histone family member X (H2AFX) and sirtuin 1. In particular, Ser140 of H2AFX also known as gamma-H2AX was found to be hyperphosphorylated in retinoblastoma, which indicated the activation of DNA damage response pathways. We also observed the activation of anti-apoptosis in retinoblastoma compared to control. These observations showed the activation of survival pathways in retinoblastoma. The identification of hyperphosphorylated protein kinases including Bromodomain containing 4 (BRD4), Lysine deficient protein kinase 1 (WNK1), and Cyclin-dependent kinase 1 (CDK1) in RB opens new avenues for the treatment of RB. These kinases can be considered as probable therapeutic targets for RB, as small-molecule inhibitors for some of these kinases are already in clinical trials for the treatment other cancers

A new measurement of the Hubble constant using Type Ia supernovae calibrated with surface brightness fluctuations

We present a new calibration of the peak absolute magnitude of SNe Type Ia based on the Surface Brightness Fluctuations (SBF) method, aimed at measuring the value of the Hubble constant. We build a sample of calibrating anchors consisting of 24 SNe hosted in galaxies having SBF distance measurements. Applying a hierarchical Bayesian approach, we calibrate the SNe luminosity and extend it into the Hubble flow by using a sample of 96 SNe Ia in the redshift range $0.02 < z < 0.075$, extracted from the Combined Pantheon Sample. We estimate a value of $H_0 = 70.50 \pm 2.37(stat) \pm 3.38(sys)$ $\text{km}\ \text{s}^{-1}\ \text{Mpc}^{-1}$(i.e.$3.4\% stat, 4.8\% sys$), which is in agreement with the value obtained using the tip of the red giant branch calibration, and consistent within the errors with the value obtained from SNe Type Ia calibrated with Cepheids and the one inferred from the analysis of the cosmic microwave background. We find that the SNe Ia distance moduli calibrated with SBF are on average larger by 0.07 mag than the ones calibrated with Cepheids. Our results point to possible differences among SNe in different types of galaxies, which could originate from different local environments and/or SNe Ia progenitor properties. Sampling different host galaxy type, SBF offers a complementary approach to Cepheids which is important in addressing possible systematics. As the SBF method has the ability to reach larger distances than Cepheids, the impending entry of LSST and JWST into operation will increase the number of SNe Ia hosted in galaxies where SBF distances can be measured, making SBF measurements attractive for improving the calibration of SNe Ia, and in the estimation of$H_0$.Comment: 22 pages, 14 figures, 9 tables. Comments are very welcom

Double “acct”: A Distinct Double-peaked Supernova Matching Pulsational Pair Instability Models

We present multiwavelength data of SN 2020acct, a double-peaked stripped-envelope supernova (SN) in NGC 2981 at ∼150 Mpc. The two peaks are temporally distinct, with maxima separated by 58 rest-frame days and a factor of 20 reduction in flux between. The first is luminous (Mr = −18.00 ± 0.02 mag) and blue (g − r = 0.27 ± 0.03 mag) and displays spectroscopic signatures of interaction with hydrogen-free circumstellar material. The second peak is fainter (Mr = −17.29 ± 0.03 mag) and has some spectroscopic similarities to an evolved stripped-envelope SN, with strong forbidden [Ca ii] and [O ii] features. No other known double-peaked SN exhibits a light curve similar to that of SN 2020acct. We find the likelihood of two individual SNe occurring in the same star-forming region within that time to be highly improbable, while an implausibly fine-tuned configuration would be required to produce two SNe from a single binary system. We find that the peculiar properties of SN 2020acct match models of pulsational pair instability (PPI), in which the initial peak is produced by collisions of shells of ejected material, shortly followed by core collapse. Pulsations from a star with a 72 M⊙ helium core provide an excellent match to the double-peaked light curve. The local galactic environment has a metallicity of 0.4 Z⊙, a level where massive single stars are not expected to retain enough mass to encounter the PPI. However, late binary mergers or a low-metallicity pocket may allow the required core mass. We measure the rate of SN 2020acct–like events to be <3.3 × 10−8 Mpc−3 yr−1 at z = 0.07, or <0.1% of the total core-collapse SN rate

Tetracycline: production, waste treatment and environmental impact assessment

The frequent occurrence of pharmaceuticals in the aquatic environment requires an assessment of their environmental impact and their negative effects in humans. Among the drugs with high harmful potential to the environment are the antibiotics that reach the environment not only, as may be expected, through the effluents from chemical and pharmaceutical industries, but mainly through the sewage and livestock; because around 25 to 75% of the ingested drugs are excreted in unchanged form after the passage through the Gastro-Intestinal Tract. Tetracycline has high world consumption, representing a human consumption of about 23 kg/day in Brazil in 2007. At the moment, researches are being made to develop new tetracycline that incorporate heavy metals (Hg, Cd, Re, Pt, Pd) to their structures in order to increase their bactericidal effect. The conventional wastewater treatment plants are not able to degrade complex organic molecules to reduce their toxicity and improve their biodegradability. For this reason new technologies, i.e., the advanced oxidation processes, are being developed to handle this demand. The objectives of this study are to review the literature on the processes of obtaining tetracycline, presenting its waste treatment methods and evaluation of their environmental impact

Ciprofloxacin, diclofenac, ibuprofen and 17α-ethinylestradiol differentially affect the activity of acetogens and methanogens in anaerobic communities

Pharmaceutical compounds end up in wastewater treatment plants but little is known on their effect towards the different microbial groups in anaerobic communities. In this work, the effect of the antibiotic Ciprooxacin (CIP), the non-steroidal anti-inammatory drugs Diclofenac (DCF) and Ibuprofen (IBP), and the hormone 17-ethinylestradiol (EE2), on the activity of acetogens and methanogens in anaerobic communities, was investigated. Microbial communities were more affected by CIP, followed by EE2, DCF and IBP, but the response of the different microbial groups was dissimilar. For concentrations of 0.01 to 0.1 mg/L, the specic methanogenic activity was not affected. Acetogenic bacteria were sensitive to CIP concentrations above 1 mg/L, while DCF and EE2 toxicity was only detected for concentrations higher than 10 mg/L, and IBP had no effect in all concentrations tested. Acetoclastic methanogens showed higher sensitivity to the presence of these micropollutants, being affect by all the tested pharmaceutical compounds although at different degrees. Hydrogenotrophic methanogens were not affected by any concentration, indicating their lower sensitivity to these compounds when compared to acetoclasts and acetogens.e Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Ana Rita Silva holds a Grant from FCT, reference SFRH/BD/131905/2017info:eu-repo/semantics/publishedVersio