90 research outputs found

    Organizational Responsiveness to Anti-offshoring Institutional Pressures

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    This study explores the extent to which organizations are responsive to pressures from institutional constituents against offshoring of information technology and business processes. Drawing on a theoretical framework that integrates institutional and strategic explanations, it proposes that organizational responsiveness to anti-offshoring institutional pressures is a function of both the characteristics of such pressures as well as organizations’ prior success with offshoring. Results based on moderated hierarchical multiple regression analyses on survey data from 84 offshoring client organizations indicate the following. First, both greater organizational expectations of enhanced social legitimacy obtained from compliance and mimetic influences from other organizations led to greater organizational responsiveness. Second, despite the strong precedent, organizational dependence on a key pressuring constituent had no effect. Third, both conflict of institutional expectations with organizational goals and greater regulatory environment uncertainty reduced responsiveness. Fourth, surprisingly, organizational success with offshoring had no direct effect on responsiveness. However, it attenuated the otherwise strong positive effect of social legitimacy and exacerbated the negative effect of regulatory environment uncertainty. Implications of these findings for research and practice are discussed

    The Moderating Effect of Top Management\u27s Collective Mindfulness on the Relationship between Top Management Support and IS Function Performance

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    As an exploratory study we apply the concept of mindfulness to examine the moderating influence of cognitive processes of top management on the relationship between its support for the IS function and the overall IS function performance. In doing so we enhance our understanding of the underlying cognitive processes associated with top management in their support toward the IS function. We trace the origins of mindfulness in the psychology area to its final possible assimilation in IS research. We then broaden the potential application of collective mindfulness in IS research and embark on developing a scale of collective mindfulness in the IS context. Examination of such possible moderating influences in the context of top management support and IS performance may open doors for future, much deeper, integration of mindfulness in IS research and may help both research and practice in the continued quest for achieving reliable performance of IS

    Employing U.S. Military Families to Provide Business Process Outsourcing Services: A Case study of Impact Sourcing and Reshoring

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    This paper describes how a startup business process outsourcing (BPO) provider named Liberty Source helped a large U.S.-based client reshore business services from an established Indian BPO provider. Founded in 2014, Liberty Source is a for-profit firm that provides a competitive alternative to offshoring while fulfilling its social mission to launch and sustain the careers of U.S. military spouses and veterans who face various employment disadvantages. Thus, the case describes reshoring in the context of impact sourcing. It addresses key impact sourcing issues pertaining to workforce development, scalability, and impact on employees. The impact was positive: the workers found the employment and stable salary were beneficial, “the military” culture fit well with the workers, and workers received considerable flexibility and greater career options. Liberty Source was able to reduce a client’s costs after reshoring the client’s processes because Liberty Source’s U.S. site had about 20 percent fewer full time equivalents (FTEs) FTEs than the original India location and because Liberty Source received subsidies. We found evidence that the offshore BPO provider and Liberty source experienced difficulties with finding enough skilled staff for the wages offered and both firms experienced attrition problems, although attrition was greater in India

    Review of 23 Years of Empirical Research on Information Technology Outsourcing Decisions and Outcomes

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    The 2010 Journal of Information Technology article, “A Review of the IT Outsourcing Empirical Literature,” analyzed 741 empirical findings on the determinants of Information Technology Outsourcing (ITO) decisions and outcomes published between 1992 and 1st quarter 2010. In this paper, we replicated the method and coded additional findings published until the end of 2014. Combining the Lacity et al. (2010) with the additional findings, we used a total of 1,170 findings to produce the most robust models on ITO decisions and outcomes to date. The model of ITO decisions includes independent variables associated with transaction attributes, outsourcing motivations, influence sources, client characteristics and capabilities, relationship characteristics, and environmental variables. The model of ITO outcomes includes independent variables associated with transaction attributes, relational and contractual governance, client and provider capabilities, client characteristics and decision characteristics. The models serve as solid foundations for researchers seeking to advance academic contributions based on strong empirical data

    The Outsourcing Unit Working Research Paper Series Paper 14/1 – Cloud Services: The Great Equalizer for

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    Acknowledgements: We thank and acknowledge our research sponsor, Accenture. In particular, we are grateful to Miguel Gabriel Custodio, IT Strategy Australia/Cloud Strategy- APAC, for his support. We also thank the International Association of Outsourcing Professionals for their support in administering a survey, and Ken Saloway and Frank Casale for connecting us with SME cloud adopters

    Novel therapy targeting Mutant-KRASG12D and Galectin-1 in Pancreatic Cancer

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    Introduction: Although, surgical resection and chemotherapy are the gold standard for treating Pancreatic Ductal Adenocarcinoma (PDAC), low patient survival rate remains the problem. The activating point mutation of the KRAS on codon-12 is present in 70–95% of PDAC cases and so far, no success has been achieved to inhibit KRAS. KRASG12D regulates cell proliferation, differentiation, apoptosis. Recent preliminary and published studies show high Galectin-1 (Gal-1) levels in both pancreatic cancer and stromal cells, which modulate tumor microenvironment and metastasis. Additionally, genetic deletion of gal1 inhibits metastasis and improves survival in KRAS mouse model of PDAC (1). Therefore, our objective is to develop a novel combination therapy for PDAC by targeting mutated KRASG12D point mutation and Gal1. This includes the delivery of KRASG12D inhibiting siRNA (siKRASG12D) using a superparamagnetic iron oxide nanoparticle (SPION) and a galectin inhibitor. Methods: ASPC1/Panc-1 (human), KPC (mouse) cells were used. Our patented SPION nano-formulation (2) has been used to deliver siKRASG12D and investigated in conjunction with Gal-1 for its anticancer efficacy. Particles were investigated for size, physico-chemical characterization (Dynamic light scattering), hemocompatibility (hemolysis assay) and the complexation of siKRAS (gel retardation assay). Cellular internalization and uptake of the particles were investigated using FAM labelled siRNA and Prussian blue assay. KRASG12D silencing was confirmed at both mRNA and protein levels. Anti-cancer efficacy of the formulation was determined using in vitro functional assays for cell viability (MTT), migration (Boyden chambers), invasion (Matrigel), clonogenicity, tumor spheroid formation, and in nude mice. Results: Our results demonstrate optimal particle size and zeta potential of SP-siKRAS formulation. SPsiKRAS efficiently internalized in PDAC cells and suppressed KRASG12D as well as its downstream targets, YAP and PDL-1. Combined targeting of siKRAS and Gal-1 inhibited cell proliferation. The formulation inhibited chemoresistance, cell proliferation, clonogenicity, migration, and invasion of pancreatic cancer cells. This resulted in activation of death related mechanisms, such as Bax, bcl-2, PARP cleavage in KRASG12D cells. Interestingly, the formulation was highly effective in inhibiting KRASG12D and growth of tumor spheroid in 3D cell models, which recapitulate the heterogeneity and pathophysiology of PDAC. This further provides a clinical validation demonstrating potential of SP-siKRAS particles to efficiently silence KRAS expression. SP-siKRAS also exhibited hemocompatibility, suggesting its potential of silencing KRAS without being toxic to the body. Additionally, the formulation was efficiently delivered in nude mice to exhibit KRasG12D silencing and inhibit tumor growth. Conclusion: This gene therapy targeting KRAS G12D mutation with a Gal-1 inhibition has a potential to modulate the oncogenic network and tumor microenvironment resulting in the repression of growth, metastasis, chemoresistance, and improvement in patient survival. This study will develop a novel sustainable therapeutic approach to target pancreatic cancer growth and improve patient survivability
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