Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-exposed seronegative sex workers (<3 years) compared to HIV seronegative low-risk controls.

<p>^a General functions are based on each protein’s gene ontology obtained from the UniProt website.</p><p>^b Statistical significance was deduced via Student’s T-test, p < 0.05.</p><p>* denotes a known association with HIV-1.</p><p>Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-exposed seronegative sex workers (<3 years) compared to HIV seronegative low-risk controls.</p

Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-positive sex workers compared to HIV seronegative low-risk controls.

<p>^a General functions are based on each protein’s gene ontology obtained from the UniProt website.</p><p>^b Statistical significance was deduced via Student’s T-test, p < 0.05.</p><p>Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-positive sex workers compared to HIV seronegative low-risk controls.</p

Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-exposed seronegative sex workers (>3 years) compared to HIV-seronegative low-risk controls.

<p>^a General functions are based on each protein’s gene ontology obtained from the UniProt website.</p><p>^b Statistical significance was deduced via Student’s T-test, p < 0.05.</p><p>* denotes a known association with HIV-1.</p><p>Proteins found to be significantly overabundant (A) and under abundant (B) in the cationic protein-depleted cervicovaginal secretions of HIV-exposed seronegative sex workers (>3 years) compared to HIV-seronegative low-risk controls.</p

HIV neutralizing activity in unprocessed and cationic protein-depleted cervicovaginal secretions.

<p>The HIV neutralizing activity of unprocessed cervicovaginal secretions (CVS) and cationic protein-depleted CVS, respectively, was assessed in pooled samples from the study groups. Green bars: HIV seronegative low-risk women (Low risk) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130404#pone.0130404.ref025" target="_blank">25</a>]; Yellow bars: HIV seronegative women with less than 3 years of reported active sex work (HESN<3yr); Blue bars: HIV seronegative women with more than 3 years of reported active sex work (HESN>3yr); Red bars: HIV seropositive sex working women (HIV positive). The results shown are from two to three representative experiments using duplicate wells (median values ±SEM).</p

Biological processes of differentially abundant proteins between female sex worker and low-risk groups.

<p><b>A:</b> HIV-exposed seronegative female sex workers for a time greater than three years <b>B:</b> HIV-exposed seronegative female sex workers for a time less than three years <b>C:</b> HIV-seropositive female sex workers (DAVID Bioinformatics Resources 6.7, UniProt) (Blue bars represent overabundant proteins and red bars represent under abundant proteins compared to the low-risk, uninfected control group).</p