Energy-Efficiency Program Evaluations: Opportunities for Learning and Inputs to Incentive Mechanisms

We analyze the evaluations of California energy-efficiency programs to assess the effectiveness of these evaluations in: 1) improving our understanding of their performance and 2) providing a check on utility incentives to overstate energy savings. We find that third-party evaluations are useful tools to achieve both ends because the programs largely did not meet their energy-savings projections, and the utility-reported savings estimates are systematically higher than the evaluated savings estimates. We also find evidence that the choice of the third-party evaluator was influential in determining the estimate of evaluated savings.energy efficiency, third-party evaluation, energy-savings measurement

Putting A Price On Carbon: A Handbook for U.S. Policymakers

This Handbook provides an overview of carbon pricing -- the types of decisions that need to be made in designing a program (including the political decisions about the use of revenue) and the expected economic impacts of alternative approaches. We conducted a thorough review of the literature, selecting a broad array of well-regarded and highly cited studies that represent a range of viewpoints. We expect this Handbook to be useful in the public debate in the United States on whether, how, and when to implement a national carbon price

How Michigan Can Meet Its Clean Power Plan Targets

This fact sheet examines how Michigan can use its existing policies and infrastructure to meet its emission standards under the Clean Power Plan while minimizing compliance costs, ensuring reliability, and harnessing economic opportunities

How Virginia Can Meet Its Clean Power Plan Targets

In August 2015, the U.S. Environmental Protection Agency (EPA) finalized the Clean Power Plan (CPP), the first-ever carbon pollution standards for existing power plants. The CPP builds on progress already under way to move the country toward a cleaner electricity system, including rapidly falling prices of renewables and increased deployment of moneysaving energy efficiency measures. The plan enables states to use a wide range of options to meet their standards, such as existing clean energy policies and power plants (the focus of this analysis), other tools to cut electricity use and increase the use of renewables, and broader initiatives such as participation in a capand- trade program or use of a carbon tax.This fact sheet examines how Virginia can use its existing policies and infrastructure to meet its emission standards under the Clean Power Plan while minimizing compliance costs, ensuring reliability, and harnessing economic opportunities

How Missouri Can Meet Its Clean Power Plan Targets

This fact sheet examines how Missouri can use its existing policies and infrastructure to meet its emission standards under the Clean Power Plan while minimizing compliance costs, ensuring reliability, and harnessing economic opportunitie

Ratification of the base of the ICS Geological Time Scale : the Global Standard Stratigraphic Age (GSSA) for the Hadean lower boundary

Peer reviewe

Wnt signaling in triple-negative breast cancer

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Essays on the optimal policy response to climate change

textUnchecked anthropogenic climate change has the potential to destroy human lives and wealth on an unprecedented scale. This dissertation analyzes from an economic perspective various public policy options to correct the market failures caused by climate change. The widespread adoption of environmentally friendly consumer products can reduce the impacts of climate change. The first chapter analyzes various methods of encouraging the market performance of these products. I build a model of observational learning in which a "green" consumer good enters a market to challenge an established "dirty" product. Among other results, I provide conditions for when financial incentives or informational campaigns should be more effective at encouraging the market performance of green products. I also provide a discussion and an empirical analysis of the performance of compact fluorescent light bulbs in the U.S. residential market, and compare the findings to the predictions of the theoretical model. The second chapter provides a critic of the macroeconomic models economists have used to determine optimal climate change abatement policies. I build a model that can incorporate more realistic ranges of uncertainty for both the occurrence of catastrophic events and societal risk aversion than economists have used in the past. Numerical simulations are then used to calculate a range of risk premiums, the magnitude of which display that previous calculations of optimal carbon dioxide taxes are too imprecise to support any particular policy recommendation. Government-backed energy-efficiency programs have become popular as components of local and national strategies to combat climate change. The effectiveness of such policies hinges on whether they provide the appropriate incentives to both energy consumers and program implementers. The third chapter analyzes evaluations of California's energy-efficiency programs to assess their effectiveness at improving our understanding of the programs' performance and providing a check on utility incentives to overstate energy savings. We find, among other results, that evaluations are useful tools to achieve both of these goals because the programs largely did not meet their energy-savings projections, and the utility savings estimates are systematically higher than the third-party savings estimates of the evaluations.Economic