HIGH Pain-related percent signal change in representative brain regions across three groups in both run 1 and run 2.

<p>Bars represent mean ± SEM.</p

Descriptive statistics for the three genotype groups studied.

<p>Descriptive statistics for the three genotype groups studied.</p

HIGH-pain related brain activations, overlaid on the MNI152 standard brain.

<p>HIGH-pain related brain activations, overlaid on the MNI152 standard brain.</p

Brain structures exhibiting a significant genotype effect for HIGH pain in the second run.

<p>For descriptive purposes, the significant cluster was partitioned in subclusters by further applying a voxelwise threshold of z = 2.3. Subclusters with a N_voxels≥20 are described.</p><p>Abbreviations: cx = cortex, g. = gyrus, HF = hippocampal formation, PAG = periaqueductal gray.</p