3 research outputs found

    Rhodium-Catalyzed Alkylation of C–H Bonds in Aromatic Amides with α,β-Unsaturated Esters

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    The alkylation of C–H bonds with α,β-unsaturated carbonyl compounds by a rhodium-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety is reported. The reaction is highly regioselective. The formation of C–C bonds occurs between the <i>ortho</i> C–H bonds in aromatic amides and the β-position of the acyclic α,β-unsaturated carbonyl compounds. The reaction is applicable to various acyclic α,β-unsaturated carbonyl compounds, such as acrylic esters, acrylamide, fumarate, maleate, and phenyl vinyl sulfone

    Rhodium-Catalyzed Alkenylation of C–H Bonds in Aromatic Amides with Alkynes

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    The rhodium-catalyzed alkenylation of C–H bonds of aromatic amides with alkynes is reported. A variety of functional groups, including OMe, OAc, Br, Cl, and even NO<sub>2</sub>, are applicable to this reaction to give the corresponding hydroarylation products. The presence of an 8-aminoquinoline group as the directing group is crucial for the success of the reaction

    Rhodium-Catalyzed Alkylation of C–H Bonds in Aromatic Amides with Styrenes via Bidentate–Chelation Assistance

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    Rhodium-catalyzed alkylation reactions of aromatic C–H bonds in aromatic amides with styrene derivatives have been developed by using an 8-aminoquinoline as a bidentate directing group. C–C bond formation selectively occurred between the <i>ortho</i> C–H bonds in aromatic amides and the terminal carbon of the styrene derivatives. The presence of an 8-aminoquinoline moiety is essential for the success of the reaction
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