18 research outputs found
Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates
Food security is an important issue
in the 21st century;
preventing
and controlling crop diseases and pests are the key to solve this
problem. The creation of new pesticides based on natural products
is an important and effective method. Herein, coumarins were selected
as parent structures, and a series of their derivatives were designed,
synthesized, and evaluated for their antiviral activities, fungicidal
activities, and insecticidal activities. We found that coumarin derivatives
exhibited good to excellent antiviral activities against tobacco mosaic
virus (TMV). The antiviral activities of I-1, I-2a, I-4b, II-2c, II-2g, II-3, and II-3b are better than that of ribavirin
at 500 μg/mL. Molecular docking research showed that these compounds
had a strong interaction with TMV CP. These compounds also showed
broad-spectrum fungicidal activities against 14 plant pathogenic fungi.
The EC50 values of I-1, I-2a, I-3c, and II-2d are in the range of 1.56–8.65
μg/mL against Rhizoctonia cerealis, Physalospora piricola, Sclerotinia sclerotiorum, and Pyricularia
grisea. Most of the compounds also displayed good
insecticidal activities against Mythimna separata. Pesticide-likeness analysis showed that these compounds are following
pesticide-likeness and have the potential to be developed as pesticide
candidates. The present work lays a foundation for the discovery of
novel pesticide lead compounds based on coumarin derivatives
Supplementary Table 2. Mount AGP information of the Hedin/2 genome result
Supplementary Table 2. Mount AGP information of the Hedin/2 genome resul
Supplementary Table 3. Map-2023 genomic anchoring result
Supplementary Table 3. Map-2023 genomic anchoring resul
Supplementary Table1. Genetic map mount comparison of Hedin/2 genome result
Supplementary Table1. Genetic map mount comparison of Hedin/2 genome resul
The GFF file, including the new genes which retains the gene IDs of the originally annotated genes and the new genes
The GFF file, including the new genes which retains the gene IDs of the originally annotated genes and the new gene
Supplementary Table 7. RNA targets of the long non-coding RNAs (lncRNAs) result of Illumina and Pacbio RNA-seq datasets
Supplementary Table 7. RNA targets of the long non-coding RNAs (lncRNAs) result of Illumina and Pacbio RNA-seq dataset
Supplementary Table 5. Alternative polyadenylation result of Illumina and Pacbio RNA-seq datasets
Supplementary Table 5. Alternative polyadenylation result of Illumina and Pacbio RNA-seq dataset
Supplementary table 9. The transcripts comparison between the Hedin reference and the generated sequences in this study
Supplementary table 9. The transcripts comparison between the Hedin reference and the generated sequences in this stud
Supplementary Table 4. Alternative splicing(AS) events of Illumina and Pacbio RNA-seq datasets
Supplementary Table 4. Alternative splicing(AS) events of Illumina and Pacbio RNA-seq dataset