HDLC-ICEC: the first realease

The python library for the IC control to GBTx, and EC control to GBT-SCA device. Please check https://github.com/simpway/HDLC-ICEC/ for update. One bug was fixed in HDLC_ICEC_LIB_CK.py: def bit_destuffing(IN): OUT=np.arange(256) k=0 num=0 for i in range(256-8): if IN[i+8]==0: # if num == 5: if (num==5 and list(IN[i+8:i+8+8]) != [0,1,1,1,1,1,1,0]): # print("bit de-stuffing") num=0 else: num=0 OUT[k]=0 k=k+1 elif num==6: #print("done") break; else: num=num+1 OUT[k]=1 k=k+1 return OUT[0:k-6]  </p

Additional file 1: of Clinicopathological features, treatment patterns, and prognosis of squamous cell carcinoma of the breast: an NCDB analysis

Figure S1. Kaplan-Meier survival analysis stratified by histology (IDC vs. SCC) and nodal status in a) HR-positive and b) HR-negative patients. (PDF 62 kb

Rethinking preemptive consumption: building mechanisms of reciprocity, contextuality, and risk hedging across scenarios

Confronted with fragmentation and retardation in understanding preemption, the authors aim to reassemble the current understanding of preemptive behaviors. Hence, we re-examine multiple mechanisms with three aspects of drive: expectancy, situational, and temporal factors, rooted in consumer psychology and cognition of social crises. Preemptive consumption occurs via three pathways. First, in the explanation of drives, objective-bound motivation, moderated by the opportunism of the outcome, can intensify the intention to behave preemptively, which echoes and extends expectation theory into self-other dual polarity. Second, from the perspective of the behavioral sequence, a defensive or aggressive strategy, tuned by the level of the behavioral barrier, can strengthen the inclination to act preemptively. Finally, an individual's concern about scarcity and the risk of farsightedness, altered by their capacity to handle inequality and threats, impacts preemptive behavior. This study has significant implications for leveraging individual motivations, ethics, and consumer-targeted communication tools.</p

Rethinking preemptive consumption: building mechanisms of reciprocity, contextuality, and risk hedging across scenarios

Confronted with fragmentation and retardation in understanding preemption, the authors aim to reassemble the current understanding of preemptive behaviors. Hence, we re-examine multiple mechanisms with three aspects of drive: expectancy, situational, and temporal factors, rooted in consumer psychology and cognition of social crises. Preemptive consumption occurs via three pathways. First, in the explanation of drives, objective-bound motivation, moderated by the opportunism of the outcome, can intensify the intention to behave preemptively, which echoes and extends expectation theory into self-other dual polarity. Second, from the perspective of the behavioral sequence, a defensive or aggressive strategy, tuned by the level of the behavioral barrier, can strengthen the inclination to act preemptively. Finally, an individual's concern about scarcity and the risk of farsightedness, altered by their capacity to handle inequality and threats, impacts preemptive behavior. This study has significant implications for leveraging individual motivations, ethics, and consumer-targeted communication tools.</p

Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes

We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthesis via carbene transfer to internal alkynes. Directed evolution of a serine-ligated P450 variant, P411-C10, yielded a lineage of engineered P411 enzymes that together accommodate a variety of internal aromatic alkynes as substrates for cyclopropenation with unprecedented efficiencies and stereoselectivities (up to 5760 TTN, and all with >99.9% ee). Using an internal aliphatic alkyne bearing a propargylic ether group, different P411 variants can selectively catalyze cyclopropene formation, carbene insertion into a propargylic C–H bond or [3 + 2]-cycloaddition. This tunable reaction selectivity further highlights the benefit of using genetically encoded catalysts to address chemoselectivity challenges

Long-Term Efficient Interfacial Solar Desalination Enabled by a Biomimetic 2D Water-Transport Structure Based on Silicone Nanofilaments

Solar-driven interfacial evaporation (SIE) has drawn increasing attention for seawater desalination. Two-dimensional water-transport structures (2D-WTS) can enhance SIE performance by reducing heat loss of conventional evaporators but suffer from poor salt resistance due to insufficient water supply, which inhibits vapor escape and thus reduces evaporation rate. Inspired by the transpiration of plant leaves, we report the design of a 2D-WTS with controllable morphology by growing silicone nanofilaments on a polyethylene/polypropylene fabric. 2D-WTS has a hierarchical micro-/nanostructure for fast water supply like the multiscale vascular system of leaves. Consequently, the separated solar evaporator composed of 2D-WTS and polypyrrole/attapulgite@aluminium photothermal sheet achieves long-term efficient SIE, i.e., high evaporation rate (2.23 kg m–2 h–1, 3.5 wt % NaCl(aq), 1 sun), stable SIE of concentrated brine over 10 days (∼2.10 kg m–2 h–1, 10 wt % NaCl(aq), 7 h irradiation per day, 1 sun), and high practical evaporation rate of 7.36 kg m–2 during 7 h outdoor SIE under weak sunlight and low temperature (0.3–0.6 sun, 2–13 °C). This is because fast water transport in 2D-WTS forms a small salt deposition area close to the edge of the horizontal area of 2D-WTS during long-term SIE, which hardly affects the vapor escape

Superelastic Clay/Silicone Composite Sponges and Their Applications for Oil/Water Separation and Solar Interfacial Evaporation

3D porous materials are of great interest in many areas of study, but it is still difficult to prepare those with high elasticity and low thermal conductivity via facile methods. Here, superelastic laponite/silicone (LS) composite sponges with low thermal conductivity are prepared via a simple approach. The LS sponges were analyzed by various characterization methods. The content of laponite nanosheets in LS sponges has a great influence on the microstructure, comprehensive mechanical properties, and thermal conductivity. LS sponges feature (i) high mechanical strength, compressibility, and elasticity, (ii) excellent superhydrophobicity/superoleophilicity, and (iii) low thermal conductivity. Consequently, LS sponges could be used for water purification, for example, oil/water separation and solar-driven interfacial evaporation in combination with carbon nanotubes (CNTs). The LS/CNTs solar evaporator has a remarkable evaporation rate of 1.77 kg m–2 h–1 for the 3.5 wt % NaCl aqueous solution under 1 kW m–2 irradiation and high salt resistance. We foresee that this study will promote the development of new 3D porous materials and their applications

Analysis and prediction models for operating speed of vehicles in expressway superlong tunnels based on geometric and traffic related parameters

Operating speeds on roads are critical indicators for evaluating traffic safety. Currently available research on the operating speed’s prediction focuses on open roads and highways. Insufficient attention has been paid, so far, to tunnels, which form bottlenecks on expressways. The present research aims to establish an operating speed prediction model for tunnels and analyze the influence of their geometric parameters on the operating speeds of vehicles. We consider the speed of vehicles collected through field measurements in the portals and lay-bys of six superlong tunnels (length greater than 3000 m). Using linear regression, a prediction model for the speed in an expressway superlong tunnel is obtained considering tunnel’s geometric parameters. The influence of various parameters on the operating speed are analyzed through comparisons with existing research findings. We establish the first operating speed prediction model for tunnels considering geometric parameters and find that the vehicle type is the most important parameter affecting the operating speed. Other important parameters include the preceding curve length up to speed observation point (PCLS), preceding tangent length (PTL) and preceding tangent length up to speed observation point (PTLS). The influence of geometric parameters on vehicle operating speed in super long tunnels differs from that observed in non-tunnel roadways. The effects of the preceding or subsequent curve radius (Rb or Ra) of the tangent section, curvature (1/R), and curve degree (DC) are not important in this case. Furthermore, we find that the influence of the posted speed limit (PSL) is closely related to the driving scene and safety awareness of drivers. These findings can improve the design and joint evaluation of tunnel geometric parameters and traffic safety.</p

Design of a Separated Solar Interfacial Evaporation System for Simultaneous Water and Salt Collection

Solar-driven interfacial evaporation (SIE) is very promising to alleviate the freshwater scarcity issue. However, salt deposition on the sample surface will reduce evaporation performance, and compromised light absorption will result in a low water collection rate in conventional SIE apparatuses. Here, we report the design of a separated SIE system composed of a polypyrrole@Co3O4@aluminum sheet and a T-shaped superhydrophilic polyethylene/polypropylene nonwoven fabric right under the sheet. The photothermal surface exposed outside the closed SIE system is separated from the evaporation surface. Thus, salt fouling of solar evaporators is thoroughly avoided and the freshwater collection rate is greatly enhanced. Compared with conventional SIE systems, the separated SIE system has many advantages: simultaneous water and salt collection, a long-term stable evaporation rate even for concentrated brine (1.25 kg m–2 h–1 under 1 kW m–2 (1 sun) illumination, 15 wt % NaCl(aq), ≥120 h), high salt collection efficiency (≥97%), and a high water collection rate under natural sunlight, e.g., 0.72 kg m–2 h–1 in early spring (0.5–0.6 sun, 19–24 °C) and 0.33 kg m–2 h–1 in cold winter (0.3–0.4 sun, −6 to 4 °C). We foresee that the separated SIE system holds great potential for practical freshwater and salt collection from seawater

Computational Exploration of Zinc Binding Groups for HDAC Inhibition

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic properties. A two-stage protocol of M05-2X calculations of a library of 48 fragments in a small model active site, followed by QM/MM hybrid calculations of the full enzyme with selected binders, is used to prospectively select potential bidentate zinc binders. The energetics and interaction patterns of several zinc binders not previously used for the inhibition of HDACs are discussed