Upper Bounds for Cyclotomic Numbers

Let $q$ be a power of a prime $p$, let $k$ be a nontrivial divisor of $q-1$ and write $e=(q-1)/k$. We study upper bounds for cyclotomic numbers $(a,b)$ of order $e$ over the finite field $\mathbb{F}_q$. A general result of our study is that $(a,b)\leq 3$ for all $a,b \in \mathbb{Z}$ if $p> (\sqrt{14})^{k/ord_k(p)}$. More conclusive results will be obtained through separate investigation of the five types of cyclotomic numbers: $(0,0), (0,a), (a,0), (a,a)$ and $(a,b)$, where $a\neq b$ and $a,b \in \{1,\dots,e-1\}$. The main idea we use is to transform equations over $\mathbb{F}_q$ into equations over the field of complex numbers on which we have more information. A major tool for the improvements we obtain over known results is new upper bounds on the norm of cyclotomic integers

Constructions of Semi-regular Relative Difference Sets

AbstractJ. A. Davis, J. Jedwab, and M. Mowbray (1998, Des. Codes Cryptogr.13, 131–146) gave two new constructions for semi-regular relative difference sets (RDSs). They asked if the two constructions could be unified. In this paper, we show that the two constructions are closely related. In fact, the second construction should be viewed as an extension of the first. Furthermore, we generalize the second construction to obtain new RDSs

On Mathon's construction of maximal arcs in Desarguesian planes. II

In a recent paper [M], Mathon gives a new construction of maximal arcs which generalizes the construction of Denniston. In relation to this construction, Mathon asks the question of determining the largest degree of a non-Denniston maximal arc arising from his new construction. In this paper, we give a nearly complete answer to this problem. Specifically, we prove that when $m\geq 5$ and $m\neq 9$, the largest $d$ of a non-Denniston maximal arc of degree $2^d$ in PG(2,2^m) generated by a {p,1}-map is (\floor {m/2} +1). This confirms our conjecture in [FLX]. For {p,q}-maps, we prove that if $m\geq 7$ and $m\neq 9$, then the largest $d$ of a non-Denniston maximal arc of degree $2^d$ in PG(2,2^m) generated by a {p,q}-map is either \floor {m/2} +1 or \floor{m/2} +2.Comment: 21 page

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication