Porous squeeze-film flow

The squeeze-film flow of a thin layer of Newtonian fluid filling the gap between a flat impermeable surface moving under a prescribed constant load and a flat thin porous bed coating a stationary flat impermeable surface is considered. Unlike in the classical case of an impermeable bed, in which an infinite time is required for the two surfaces to touch, for a porous bed contact occurs in a finite contact time. Using a lubrication approximation an implicit expression for the fluid layer thickness and an explicit expression for the contact time are obtained and analysed. In addition, the fluid particle paths are calculated, and the penetration depths of fluid particles into the porous bed are determined. In particular, the behaviour in the asymptotic limit of small permeability, in which the contact time is large but finite, is investigated. Finally, the results are interpreted in the context of lubrication in the human knee joint, and some conclusions are drawn about the contact time of the cartilage-coated femoral condyles and tibial plateau and the penetration of nutrients into the cartilage

Squeeze-Film Flow in the Presence of a Thin Porous Bed, with Application to the Human Knee Joint

Motivated by the desire for a better understanding of the lubrication of the human knee joint, the squeeze-film flow of a thin layer of Newtonian fluid (representing the synovial fluid) filling the gap between a flat impermeable surface (representing the femoral condyles) and a flat thin porous bed (representing the articular cartilage) coating a stationary flat impermeable surface (representing the tibial plateau) is considered. As the impermeable surface approaches the porous bed under a prescribed constant load all of the fluid is squeezed out of the gap in a finite contact time. In the context of the knee, the size of this contact time suggests that when a person stands still for a short period of time their knees may be fluid lubricated, but that when they stand still for a longer period of time contact between the cartilage-coated surfaces may occur. The fluid particle paths are calculated, and the penetration depths of fluid particles into the porous bed are determined. In the context of the knee, these penetration depths provide a measure of how far into the cartilage nutrients are carried by the synovial fluid, and suggest that when a person stands still nutrients initially in the fluid layer penetrate only a relatively small distance into the cartilage. However, the model also suggests that the cumulative effect of repeated loading and unloading of the knees during physical activity such as walking or running may be sufficient to carry nutrients deep into the cartilage

The Distance to the Cygnus Loop from Hubble Space Telescope Imaging of the Primary Shock Front

We present a Hubble Space Telescope/WFPC2 narrow-band H-alpha image of a region on the northeastern limb of the Cygnus Loop supernova remnant. This location provides a detailed example of where the primary blast wave first encounters the surrounding interstellar medium. The filament structure is seen in exquisite detail in this image, which was obtained primarily as an EARLY ACQuisition image for a follow-up spectroscopic program. We compare the HST image to a digitized version of the POSS-I red plate to measure the proper motion of this filament. By combining this value for the proper motion with previous measurements of the shock velocity at this position we find that the distance to the Cygnus Loop is 440 (+130, -100) pc, considerably smaller than the canonical value of 770 pc. We briefly discuss the ramifications of this new distance estimate for our understanding of this prototypical supernova remnant.Comment: 18 pages, 3 Figures (2 JPEG and one Postscript

Power Spectrum Estimators For Large CMB Datasets

Forthcoming high-resolution observations of the Cosmic Microwave Background (CMB) radiation will generate datasets many orders of magnitude larger than have been obtained to date. The size and complexity of such datasets presents a very serious challenge to analysing them with existing or anticipated computers. Here we present an investigation of the currently favored algorithm for obtaining the power spectrum from a sky-temperature map --- the quadratic estimator. We show that, whilst improving on direct evaluation of the likelihood function, current implementations still inherently scale as the equivalent of the cube of the number of pixels or worse, and demonstrate the critical importance of choosing the right implementation for a particular dataset.Comment: 8 pages LATEX, no figures, corrected misaligned columns in table

On the jets, kinks, and spheromaks formed by a planar magnetized coaxial gun

Measurements of the various plasma configurations produced by a planar magnetized coaxial gun provide insight into the magnetic topology evolution resulting from magnetic helicity injection. Important features of the experiments are a very simple coaxial gun design so that all observed geometrical complexity is due to the intrinsic physical dynamics rather than the source shape and use of a fast multiple-frame digital camera which provides direct imaging of topologically complex shapes and dynamics. Three key experimental findings were obtained: (1) formation of an axial collimated jet [Hsu and Bellan, Mon. Not. R. Astron. Soc. 334, 257 (2002)] that is consistent with a magnetohydrodynamic description of astrophysical jets, (2) identification of the kink instability when this jet satisfies the Kruskal-Shafranov limit, and (3) the nonlinear properties of the kink instability providing a conversion of toroidal to poloidal flux as required for spheromak formation by a coaxial magnetized source [Hsu and Bellan, Phys. Rev. Lett. 90, 215002 (2003)]. A new interpretation is proposed for how the n=1 central column instability provides flux amplification during spheromak formation and sustainment, and it is shown that jet collimation can occur within one rotation of the background poloidal field.Comment: Physics of Plasmas (accepted

Resistance and Resignation:Responses to Typecasting in British Acting

This article draws on 38 in-depth interviews with British actors to explore the operation of typecasting. First, we argue that typecasting acts as the key mechanism through which the ‘somatic norm’ is established in British acting. It delivers an oversupply of leading roles for white, male, middle-class actors while ensuring that those who deviate somatically are restricted to largely socially caricatured roles. Second, we focus on the career trajectories of ‘othered’ actors. While they frequently experience acting roles as offensive and discriminatory, we demonstrate how most nonetheless reluctantly accept the terms of their ‘type’ in order to survive and succeed. Third, we focus on the minority who have attempted to challenge their type. Here we find that successful resistance is accomplished by carefully choosing work that subverts the somatic norm. However, the ability to exercise such choice is highly contingent on resources associated with an actor’s class origin

Spectro-microscopy of single and multi-layer graphene supported by a weakly interacting substrate

We report measurements of the electronic structure and surface morphology of exfoliated graphene on an insulating substrate using angle-resolved photoemission and low energy electron diffraction. Our results show that although exfoliated graphene is microscopically corrugated, the valence band retains a massless fermionic dispersion, with a Fermi velocity of ~10^6 m/s. We observe a close relationship between the morphology and electronic structure, which suggests that controlling the interaction between graphene and the supporting substrate is essential for graphene device applications.Comment: 10 pages of text, 4 JPEG figure

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo.

Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to convert a non-toxic prodrug into a cytotoxic drug specifically at the tumor site by expressing a prodrug-converting enzyme (PCE). Safe doses of the favored prodrug CB1954 lead to peak concentrations of 6.3 μM in patient sera, but at these concentration(s) known nitroreductase (NTR) PCEs for this prodrug show low activity. Furthermore, efficacious and safe Clostridium strains that stably express a PCE have not been reported. Here we identify a novel nitroreductase from Neisseria meningitidis, NmeNTR, which is able to activate CB1954 at clinically-achievable serum concentrations. An NmeNTR expression cassette, which does not contain an antibiotic resistance marker, was stably localized to the chromosome of Clostridium sporogenes using a new integration method, and the strain was disabled for safety and containment by making it a uracil auxotroph. The efficacy of Clostridium-Directed Enzyme Prodrug Therapy (CDEPT) using this system was demonstrated in a mouse xenograft model of human colon carcinoma. Substantial tumor suppression was achieved, and several animals were cured. These encouraging data suggest that the novel enzyme and strain engineering approach represent a promising platform for the clinical development of CDEPT

Squeeze-film flow between a curved impermeable bearing and a flat porous bed

Axisymmetric squeeze-film flow in the thin gap between a stationary flat thin porous bed and a curved impermeable bearing moving under a prescribed constant load is analysed. The unsteady Reynolds equation is formulated and solved for the fluid pressure. This solution is used to obtain the time for the minimum fluid layer thickness to reduce to a given value, and, in particular, the finite time for the bearing and the bed to come into contact. The effect of varying the shape of the bearing and the permeability of the layer is investigated, and, in particular, it is found that both the contact time and the fluid pressure behave qualitatively differently for beds with small and large permeabilities. In addition, the paths of fluid particles initially situated in both the fluid layer and the porous bed are calculated. In particular, it is shown that, unlike in the case of a flat bearing, for a curved bearing there are fluid particles, initially situated in the fluid layer, that flow from the fluid layer into the porous bed and then re-emerge into the fluid layer, and the region in which these fluid particles are initially situated is determined