9,660 research outputs found

    The CDF MiniPlug Calorimeters at the Tevatron

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    Two MiniPlug calorimeters, designed to measure the energy and lateral position of particles in the pseudorapidity region of 3.6<|eta|<5.1 of the CDF detector, have been installed as part of the Run II CDF upgrade at the Tevatron collider. Detector performance and first results from pˉp\bar pp collision data are presented.Comment: Presented at `Frontier Detectors for Frontier Physics; 9th Pisa Meeting on Advanced Detectors', Biodola, Italy, 25-31 May 2003. 2 page

    Absorption-free optical control of spin systems:the quantum Zeno effect in optical pumping

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    We show that atomic spin motion can be controlled by circularly polarized light without light absorption in the strong pumping limit. In this limit, the pumping light, which drives the empty spin state, destroys the Zeeman coherence effectively and freezes the coherent transition via the quantum Zeno effect. It is verified experimentally that the amount of light absorption decreases asymptotically to zero as the incident light intensity is increased.Comment: 4 pages with 4 figure

    Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination.

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    The lethality of the aggressive brain tumor glioblastoma multiforme (GBM) results in part from its strong propensity to invade surrounding normal brain tissue. Although oncogenic drivers such as epidermal growth factor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the motility and invasiveness of GBM cells via phosphatidylinostitol 3-kinase activation, other unexplored mechanisms may also contribute to malignancy. Here we demonstrate that several components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling including VANGL1, VANGL2 and FZD7 are transcriptionally upregulated in glioma and correlate with poorer patient outcome. Knockdown of the core PCP pathway component VANGL1 suppresses the motility of GBM cell lines, pointing to an important mechanistic role for this pathway in glioblastoma malignancy. We further observe that restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression in GBM also correlates with poor prognosis, reduces GBM cell migration and invasiveness by suppressing PCP signaling. Our observations indicate that Nrdp1 physically interacts with the Vangl1 and Vangl2 proteins to mediate the K63-linked polyubiquitination of the Dishevelled, Egl-10 and Pleckstrin (DEP) domain of the Wnt pathway protein Dishevelled (Dvl). Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficient Dvl recruitment to the plasma membrane upon Wnt stimulation of Fzd receptor and for the propagation of downstream signals. We conclude that the PCP pathway contributes significantly to the motility and hence the invasiveness of GBM cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechanism. We propose that the upregulation of core PCP components, together with the loss of the key negative regulator Nrdp1, act coordinately to promote GBM invasiveness and malignancy

    Motion-Induced Magnetic Resonance of Rb Atoms in a Periodic Magnetostatic Field

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    We demonstrate that transitions between Zeeman-split sublevels of Rb atoms are resonantly induced by the motion of the atoms (velocity: about 100 m/s) in a periodic magnetostatic field (period: 1 mm) when the Zeeman splitting corresponds to the frequency of the magnetic field experienced by the moving atoms. A circularly polarized laser beam polarizes Rb atoms with a velocity selected using the Doppler effect and detects their magnetic resonance in a thin cell, to which the periodic field is applied with the arrays of parallel current-carrying wires.Comment: 4 pages, 4 figures; minor corrections, Ref. [9] removed, published in PR

    Ground-state electric quadrupole moment of 31Al

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    Ground-state electric quadrupole moment of 31Al (I =5/2+, T_1/2 = 644(25) ms) has been measured by means of the beta-NMR spectroscopy using a spin-polarized 31Al beam produced in the projectile fragmentation reaction. The obtained Q moment, |Q_exp(31Al)| = 112(32)emb, are in agreement with conventional shell model calculations within the sd valence space. Previous result on the magnetic moment also supports the validity of the sd model in this isotope, and thus it is concluded that 31Al is located outside of the island of inversion.Comment: 5 page

    Laser frequency locking with 46 GHz offset using an electro-optic modulator for magneto-optical trapping of francium atoms

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    We demonstrated a frequency offset locking between two laser sources using a waveguide-type electro-optic modulator (EOM) with 10th-order sidebands for magneto-optical trapping of Fr atoms. The frequency locking error signal was successfully obtained by performing delayed self-homodyne detection of the beat signal between the repumping frequency and the 10th-order sideband component of the trapping light. Sweeping the trapping-light and repumping-light frequencies with keeping its frequency difference of 46 GHz was confirmed over 1 GHz by monitoring the Doppler absorption profile of I2. This technique enables us to search for a resonance frequency of magneto-optical trapping of Fr.Comment: 6 pages, 6 figure

    Impact ionization coefficients of 4H silicon carbide

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    Anisotropy of the impact ionization coefficients of 4H silicon carbide is investigated by means of the avalanche breakdown behavior of p+n diodes on (0001) and (11[overline 2]0) 4H silicon carbide epitaxial wafers. The impact ionization coefficients are extracted from the avalanche breakdown voltages and the multiplication of a reverse leakage current, due to impact ionization of these p+n diodes. The breakdown voltage of a p+n diode on a (11[overline 2]0) wafer is 60% of that on a (0001) wafer, and the extracted impact ionization coefficients of 4H silicon carbide show large anisotropy. We have shown that the anisotropy of the impact ionization coefficients is related to the anisotropy of carrier heating and drift velocity, which are due to the highly anisotropic electronic structure of 4H silicon carbide
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