Current and Emerging Treatment Options for Patients with Metastatic EGFR-Mutated Non Small Cell Lung Cancer After Progression on Osimertinib and Platinum-Based Chemotherapy: A Podcast Discussion

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Pulmonary function testing and Computed Tomography findings.

<p>*Total lung capacity, in all other cases FVC and TLC were similar</p><p>NSIP- non-specific interstitial pneumonia</p><p>UIP- usual interstitial pneumonia</p><p>Fib nos- fibrosis not otherwise specified</p><p>EMPHY- emphysema</p><p>NA- not assessed/available</p><p>Pulmonary function testing and Computed Tomography findings.</p

Demographics, smoking history and SSc subtype and serology.

<p>NA- not assessed/available</p><p>lcSSc- limited cutaneous systemic sclerosis</p><p>dcSSc- diffuse cutaneous systemic sclerosis</p><p>SSc/PPM- Systemic sclerosis and polymyositis overlap</p><p>ACA- anticentromere antibody</p><p>SCL-70- anti-SCL 70 antibody</p><p>RNA Pol- anti-RNA polymerase III antibody</p><p>* SCL-70 not assessed</p><p>Demographics, smoking history and SSc subtype and serology.</p

Computed Tomography showing (A) a left upper lobe lung mass with UIP basilar predominant fibrosis and (B) a left lower lobe consolidation (lung cancer) with NSIP.

<p>Computed Tomography showing (A) a left upper lobe lung mass with UIP basilar predominant fibrosis and (B) a left lower lobe consolidation (lung cancer) with NSIP.</p

Tumor characteristics and prognosis.

<p>NA- not assessed/available</p><p>WT: wild type</p><p>Tumor characteristics and prognosis.</p

Sections from the tumor of one of the patients with hematoxylin and eosin staining shows infiltrating tumor glands with acinar, lepidic and focal papillary features with surrounding areas of dense fibrosis and scattered chronic inflammation (A).

<p>These tumor cells stain positive with TTF-1 (B).</p