The frequency distribution of bisphosphonate and raloxifene prescriptions by health care institution type and specialty in Korea in 2010.

<p>^a Of the total 108,406 prescriptions, 28 prescriptions were excluded: 3 prescriptions were missing matching variable for types of health care institutions and 25 prescriptions were issued from oriental medical clinics.</p><p>The frequency distribution of bisphosphonate and raloxifene prescriptions by health care institution type and specialty in Korea in 2010.</p

The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.

<p>The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.</p

The frequency and proportion of osteoporosis patients by age, comorbidities, fracture by site, concurrent medication, and medical insurance type in Korea in 2010.

<p>SD, Standard deviation GERD, Gastroesophageal reflux disease</p><p>^a Cochran–Armitage test for trend analysis</p><p>^b Fisher’s exact test</p><p>^c Vertebra (M48.4, M48.5, S22.0, S22.1, S32.0), Hip (S72.0, S72.1), Distal radius (S52.5, S52.6), Humerus (S42.2, S42.3)</p><p>The frequency and proportion of osteoporosis patients by age, comorbidities, fracture by site, concurrent medication, and medical insurance type in Korea in 2010.</p

Regional distribution of proportion of raloxifene prescription standardized in DDDs/1,000 patients/day.

<p>The Seoul metropolitan area had higher proportion of raloxifene prescriptions among Korean osteoporosis female patients. (The map came from the official site of Statistics Korea, <a href="https://sgis.kostat.go.kr/statbd/statbd_03.vw" target="_blank">https://sgis.kostat.go.kr/statbd/statbd_03.vw</a>)</p

Flowchart of study subject selection.

<p>In the 3% sample data of national health insurance claims database, 51,671 were diagnosed with osteoporosis and 26,881 were prescribed with bisphosphonate or raloxifene among them.</p