Laser-Induced Bipolar ElectrochemistryOn-Demand Formation of Bipolar Electrodes in a Solid Polymer Light-Emitting Electrochemical Cell

Bipolar electrochemistry (BPEC) is a versatile and powerful technique that has found applications in sensing, chemical synthesis, catalysis, fuel cells, and batteries, among others. In BPEC, the reactions of interest occur at a wireless, bipolar electrode (BPE). BPEC is most commonly carried out in an electrochemical cell that contains an electrolyte solution, in which a metallic BPE is immersed and polarized when the wired driving electrodes are biased. In this article, we demonstrate BPEC in a solid light-emitting electrochemical cell (LEC) that does not initially contain a BPE. Shining a focused laser beam onto the mixed conductor LEC film causes the illuminated spot to function as a BPE from which redox reactions are induced and visualized. Separate experiments using a photosensitizer (widely used in polymer solar cells) confirm that a BPE is formed on-demand via photoabsorption that causes the illuminated spot to have elevated photoconductivity. The simplicity of laser-induced BPEC offers exciting opportunities to explore sciences and applications of BPEC in the new realm of solid-state organic photonic devices

Peripheral blood MicroRNAs as biomarkers of schizophrenia: expectations from a meta-analysis that combines deep learning methods

This study aimed at identifying reliable differentially expressed miRNAs (DEMs) for schizophrenia in blood via meta-analyses combined with deep learning methods. First, we meta-analysed published DEMs. Then, we enriched the pool of schizophrenia-associated miRNAs by applying two computational learning methods to identify candidate biomarkers and verified the results in external datasets. In total, 27 DEMs were found to be statistically significant (p  A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.</p

Room-Temperature Synthesis of Hydroxylnaphthalene-1,4-dione Derivative Catalyzed by Phenylphosphinic Acid

<div><p></p><p>An efficient one-pot synthesis of hydroxylnaphthalene-1,4-dione derivatives is accomplished by a three-component reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes, and amines in water under ambient temperature catalyzed by phenylphosphinic acid. This method has the advantages of good yield, mild reaction conditions, simple workup, environmental friendliness and cost efficiency.</p> </div

The average prediction accuracies (%) for inflow prediction using different methods.

<p>The average prediction accuracies (%) for inflow prediction using different methods.</p

The average prediction accuracies (%) on different datasets in the case of outflow.

<p>The average prediction accuracies (%) on different datasets in the case of outflow.</p

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

13 janvier 19281928/01/13 (A29,N9890)

Effects of Spc1 protein kinase upon hotspot recombination after Atf1 is brought to the chromosome.

<p>(A) The 5′ and 3′ regulatory regions of the <i>atf1⁺</i> gene were used to drive expression of the indicated proteins. These contain the DNA binding domain of Gal4 protein (Gal4DBD). (B) Recombination assay. Strains harboring the indicated <i>ade6</i> alleles were crossed and the meiotic products were genotyped to determine the frequencies of <i>ade6⁺</i> recombinants. (C) Recombinant frequencies. Cells of the indicated genotypes and expressing the indicated proteins were tested for their proficiencies of recombination for <i>ade6</i> alleles with (<i>gal4BS</i>) or without (<i>gal4Control</i>) a Gal4 DNA binding site.</p

Genotypes of <i>S. pombe</i> strains used in this study.

1<p>All strains were also <i>ura4-D18 leu1-32</i>.</p

Characteristics of the experimental system.

<p>(A) Relevant features of meiotic recombination hotspot <i>ade6-M26</i>. The Spc1 kinase-regulated, Atf1-Pcr1-<i>M26</i> protein-DNA complex promotes the initiation of meiotic recombination catalyzed by meiotic recombination protein Rec12 (Spo11). (B) Relative positions of <i>ade6</i> alleles used in this study. (C) DNA sequences of <i>ade6</i> alleles. Individual mutations are depicted by bold lower case. Each mutant allele encodes a translational stop codon (5′-UGA-3′ or 5′-UAG-3′). The <i>ade6-M26</i> allele creates a DNA binding site for Atf1-Pcr1 heterodimer (box), its matching negative control allele <i>ade6-M375</i> does not. The <i>ade6-gal4BS</i> allele creates a DNA binding site for Gal4 protein (box), its matching negative control allele <i>ade6-gal4Control</i> does not.</p