1 research outputs found
Magnesium Ethoxide Promoted Conversion of Nitriles to Amidines and Its Application in 5,6-Dihydroimidazobenzoxazepine Synthesis
Magnesium
ethoxide has been shown to be a mild, safe, and scalable
alternative to trimethylaluminum for the direct addition of amines
to aryl nitriles to access cyclic amidines. A variety of electronically
diverse oxa-, thia-, and diazepine products were successfully synthesized
in moderate to high yields. Further elaboration of these compounds
to 5,6-dihydroimidazobenzoxazepines, a privileged class of pharmacologically
active heterocycles, highlights the utility of this method