22 research outputs found

    Highly Stretchable Microsupercapacitor Arrays with Honeycomb Structures for Integrated Wearable Electronic Systems

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    The rapid development of portable and wearable electronics has greatly increased the demand for energy storage devices with similar physical properties and integration capability. This paper introduces a honeycomb polydimethylsiloxane substrate for stretchable microsupercapacitor (MSC) arrays, which enables facile integration with other electronics. The honeycomb structure can accommodate a large deformation without producing excessive strain in the MSCs and interconnects. The results of this study show that such stretchable MSC arrays with single-walled carbon nanotube electrodes demonstrate excellent rate capability and power performance as well as electrochemical stability up to 150% (zero prestrain) or 275% (−50% prestrain) stretching and under excessive bending or twisting. The present stretchable MSC arrays with honeycomb structures show high potential for integration with other electronics, such as energy harvesters, power management circuits, wireless charging circuits, and various sensors, encompassing a wide range of wearable, bioimplantable electronic systems

    Study on the activity and mechanism of skimmianine against human non-small cell lung cancer

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    <p>The present research was to investigate the effects of skimmianine (SK) in four non-small cell lung cancer (NSCLC) cells. We found that SK can significantly inhibit the growth of NSCLC cells and markedly induce apoptosis in NSCLC cells. The effects of growth inhibition and apoptosis induction were in a concentration–response relationship and caspase-dependent manner.</p

    Specificity of the mRT-PCR assay.

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    <p>Lane M: molecular marker. Lane 1: a mixture containing equine-origin H3N8 (A/canine/Colorado/6723-8/2008; 148 bp predicted size), hH3N2 (A/Jiangxi/262/05; 303 bp predicted size), H1N1/2009 CIV (A/canine/Beijing/cau2/2009; 407 bp predicted size), and cH3N2 (A/canine/Beijing/364/2009; 544 bp predicted size) influenza viruses. Lane 2: equine-origin H3N8 CIV (A/canine/Colorado/6723-8/2008). Lane 3: hH3N2 influenza virus (A/Jiangxi/262/2005). Lane 4: H1N1/2009 CIV (A/canine/Beijing/cau2/2009). Lane 5: cH3N2 influenza virus (A/canine/Beijing/364/2009). Lane 6: avian-origin H9N2 influenza virus (A/chicken/Jiangsu/TS/2010). Line 7: avian-origin H5N1 influenza virus (A/chicken/Sheny/0606/2008). Lane 8: CDV (CDV-WZ). Lane 9: CPIV. Lane 10: CAV-2. Lane 11: negative control allantoic fluid.</p

    Weight loss and lung virus titration in mice inoculated with H4N6 AIVs.

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    <p>Six-week-old female BALB/c mice (n = 3 mice/group) were inoculated i.n. with 10<sup>6</sup> EID<sub>50</sub> of virus. The body weights of inoculated mice were measured daily and are represented as percentages of weight on the day of inoculation (day 0). The averages for each group are shown (A).The lungs of each mouse in each group were collected at 3 and 5 dpi, respectively, for virus titration (B).</p

    Contact transmission of H4N6 AIVs in guinea pigs.

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    <p>Three guinea pigs were intranasally inoculated with 10<sup>6</sup> EID<sub>50</sub> of A/mallard/Beijing/10/2016 (A) or A/mallard/Beijing/16/2016 (B) viruses. At 24 hpi, the inoculated guinea pigs were placed in a cage with three naive guinea pigs. Nasal wash titers are plotted as a function of time post-inoculation. Titers of intranasally inoculated animals are represented by solid lines and filled squares; titers of exposed guinea pigs are shown with dashed lines and filled triangles.</p

    Virulence and death pattern of mice infected with different H9N2 viruses.

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    <p>Five-week-old BALB/c mice (five/group) were inoculated intranasally with different H9N2 viruses, SD16 (A), SD16-MA (B), SD16:MA PB2 (C), or SD16-M147L/E627K (D). Doses of 10<sup>4</sup> to 10<sup>6</sup> pfu (A) or 10<sup>2</sup> to 10<sup>5</sup> pfu (B, C, D) were used.</p

    The genotypic evolution of H4N6 AIVs in China from 2000 to 2016.

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    <p>The eight gene segments listed are (top to bottom): PB2, PB1, PA, HA, NP, NA, M, and NS genes. The colors of the eight gene segments of the first isolate (A/duck/Nanchang/4-165/2000) were defined to be the same, and a new color represent a different lineage from this strain. The abbreviation of virus which possessed the corresponding genotype are listed below the genotype. The gene constellation for different genotypes, the viruses that possessed these, and the abbreviation of virus name are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184437#pone.0184437.s002" target="_blank">S1 Table</a>.</p

    Viral RNA polymerase activity and Viral growth kinetics in MDCK and A549 cells.

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    <p>(A) Polymerase activity of SD16 with different PB2 mutations in a minigenome assay. Four protein expression plasmids (PB2, PB1, PA, NP) for the RNP combinations were transfected into 293T cells together with luciferase reporter plasmid pYH-Luci and internal control plasmid Renilla, as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040752#s2" target="_blank">Materials and Methods</a>. The values shown are means ± SD of results for three independent experiments and are standardized to the activity of SD16 (100%). *, <i>P</i><0.05 compared with that of SD16-infected cells. (B, C, D, E) Viral growth kinetics of reassortant viruses and PB2 mutants in MDCK and A549 cells. Confluent momolayers of cells were infected with rescued H9N2 viruses at an MOI of 0.01. Cell supernatants were harvested every 12 hours until 60 hpi and titrated by plaque assay on MDCK cells. Each data point represents the mean virus yield from three individually infected wells ± SD. (B) reassortant viruses in MDCK cells, (C) PB2 mutants in MDCK cells, (D) reassortant viruses in A549 cells, (E) PB2 mutants in A549 cells.</p
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