Strategic planning schemes of mixed-use developments to support urban regeneration in South Korea

노트 : 19TH ANNUAL PACIFIC-RIM REAL ESTATE SOCIETY CONFERENCE, MELBOURNE AUSTRALIA, 13-16 JANUARY 201

Neuroscience : Canadian 3rd Edition

This project is made possible with funding by the Government of Ontario and through eCampusOntario’s support of the Virtual Learning Strategy.I. Unit 1 - Building Blocks of the BrainII. Unit 2 - Building and Changing Hardware of the BrainIII. Unit 3 - NeurodegenerationIV. Unit 4 - Fundamental Neuroscience Techniques (and when to use them)V. Unit 5 - Emergent Topics in NeuroscienceThis is an updated Open Educational Resource designed to enhance the learning of the fundamentals of neuroscience taught at the undergraduate level

Comparative Histologic Analysis of Coronally Advanced Flap With and Without Collagen Membrane for Root Coverage

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142033/1/jper0779.pd

1 A Performance Comparison Study of Ad Hoc Wireless Multicast Protocols

Abstract—In this paper we investigate the performance of multicast routing protocols in wireless mobile ad hoc networks. An ad hoc network is composed of mobile nodes without the presence of a wired support infrastructure. In this environment, routing/multicasting protocols are faced with the challenge of producing multihop routes under host mobility and bandwidth constraints. In recent years, a number of new multicast protocols of different styles have been proposed for ad hoc networks. However, systematic performance evaluations and comparative analysis of these protocols in a common realistic environment has not yet been performed. In this study, we simulate a set of representative wireless ad hoc multicast protocols and evaluate them in various network scenarios. The relative strengths, weaknesses, and applicability of each multicast protocol to diverse situations are studied and discussed. I

Cyclin D1 integrates G9a-mediated histone methylation.

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle progression and mitochondrial metabolism. Herein, we show that cyclin D1 enhanced H3K9 dimethylation though direct association with G9a. Endogenous cyclin D1 was required for the recruitment of G9a to target genes in chromatin, for G9a-induced H3K9me2 of histones, and for NL-LAD interaction. The finding that cyclin D1 is required for recruitment of G9a to target genes in chromatin and for H3K9 dimethylation, identifies a novel mechanism coordinating protein methylation

Data-Driven Goal Recognition Design for General Behavioral Agents

Goal recognition design aims to make limited modifications to decision-making environments with the goal of making it easier to infer the goals of agents acting within those environments. Although various research efforts have been made in goal recognition design, existing approaches are computationally demanding and often assume that agents are (near-)optimal in their decision-making. To address these limitations, we introduce a data-driven approach to goal recognition design that can account for agents with general behavioral models. Following existing literature, we use worst-case distinctiveness($\textit{wcd}$) as a measure of the difficulty in inferring the goal of an agent in a decision-making environment. Our approach begins by training a machine learning model to predict the $\textit{wcd}$ for a given environment and the agent behavior model. We then propose a gradient-based optimization framework that accommodates various constraints to optimize decision-making environments for enhanced goal recognition. Through extensive simulations, we demonstrate that our approach outperforms existing methods in reducing $\textit{wcd}$ and enhancing runtime efficiency in conventional setup. Moreover, our approach also adapts to settings in which existing approaches do not apply, such as those involving flexible budget constraints, more complex environments, and suboptimal agent behavior. Finally, we have conducted human-subject experiments which confirm that our method can create environments that facilitate efficient goal recognition from real-world human decision-makers

The Role of Lipids During Embryonic Development of the Euphausiids Euphausia Pacifica and Thysanoessa Spinifera

To understand the role of lipids during early embryogenesis, major lipid classes together with individual fatty acid and sterol composition were determined in embryos from multiple developmental stages of the euphausiids Euphausia pacifica and Thysanoessa spinifera. Average lipid content in embryos of E. pacifica and T. spiniferafrom the earliest stage (multicell) were 4.45 and 3.69 µg embryo-1,respectively. During development, the lipid content decreased at similar rates in the embryos of both species. In contrast to many crustacean eggs, phospholipids were the dominant lipid class in all embryonic stages, with decreasing concentrations seen during development. Individual fatty acids and sterols showed selective utilization during early developmental stages. The dominant fatty acids were 16:0 and 16:1ω7 and 20:5ω3, with most polyunsaturated fatty acids preferentially metabolized throughout early stages. An exception was 22:6ω3, which remained near constant through all stages. Cholesterol was the dominant sterol (\u3e82% of total sterols) in embryos, with only minor changes during development. The appearance of algal sterols and fatty alcohols, including phytol, in T. spinifera embryos suggests that considerable amounts of algal lipids are directly allocated to eggs during vitellogenesis. Despite the substantial changes in lipid amount and composition during embryo development, the presence of phospholipids as the dominate lipid store acts to moderate changes in egg-sinking rate for both species until the late (early and late limb-bud) stages of development