4,329 research outputs found

    Bridging The Divide: How Business Ownership Can Help Close the Racial Wealth Gap

    Get PDF
    Our nation faces significant challenges addressing the growing racial wealth gap. This white paper, written by Joyce Klein, Director of FIELD at the Aspen Institute, outlines the role that business ownership can and does play in building wealth for people of color.Latinos and African Americans holder relatively low levels of business assets, contributing to their lower levels of wealth overall. Yet there are trends in the right direction: rates of business creation among these entrepreneurs are increasing, and now exceed those of whites. Particularly among African Americans, higher levels of college attainment combined with expanded contracting opportunities are enabling movement into more lucrative markets and sectors.While there are positive signs, low levels of personal wealth and challenges in accessing business credit continue to be primary factors limiting the growth of firms owned by Latinos and African Americans. Relatively high and growing levels of student debt further complicate the financial challenges faced by entrepreneurs of color. Lower levels of education among Latinos constrain their ability to move into higher-growth, higher-revenue sectors, and also affect the skills they bring to businesses they create.The white paper outlines short- and long-term recommendations to address the racial wealth gap through business ownership strategies. In the short-term, continuing and expanding efforts to increase access to capital, skills, networks, and markets will be needed to realize the promise that business ownership holds for addressing the racial wealth gap. In the long-term, universal policies to narrow the racial wealth gap -- such as those aimed at raising the quality of education, building savings, and increasing financial inclusion -- will be critical

    Forging Ahead: Early Lessons

    Get PDF
    Outlines outcomes and lessons of the Scale Academy for Microenterprise Development's operational grants, training, and technical support for microenterprise organizations. Examines grantees' progress in and strategies for expanding services sustainably

    Multimodal Machine Learning-based Knee Osteoarthritis Progression Prediction from Plain Radiographs and Clinical Data

    Get PDF
    Knee osteoarthritis (OA) is the most common musculoskeletal disease without a cure, and current treatment options are limited to symptomatic relief. Prediction of OA progression is a very challenging and timely issue, and it could, if resolved, accelerate the disease modifying drug development and ultimately help to prevent millions of total joint replacement surgeries performed annually. Here, we present a multi-modal machine learning-based OA progression prediction model that utilizes raw radiographic data, clinical examination results and previous medical history of the patient. We validated this approach on an independent test set of 3,918 knee images from 2,129 subjects. Our method yielded area under the ROC curve (AUC) of 0.79 (0.78-0.81) and Average Precision (AP) of 0.68 (0.66-0.70). In contrast, a reference approach, based on logistic regression, yielded AUC of 0.75 (0.74-0.77) and AP of 0.62 (0.60-0.64). The proposed method could significantly improve the subject selection process for OA drug-development trials and help the development of personalized therapeutic plans

    Statistics of nested spiral self-avoiding loops: exact results on the square and triangular lattices

    Full text link
    The statistics of nested spiral self-avoiding loops, which is closely related to the partition of integers into decreasing parts, is studied on the square and triangular lattices.Comment: Old paper, for archiving. 7 pages, 2 figures, epsf, IOP macr

    Sustained Use of the Impella 50 Heart Pump Enables Bridge to Clinical Decisions in 34 Patients

    Get PDF
    We studied whether sustained hemodynamic support (\u3e7 d) with the Impella 5.0 heart pump can be used as a bridge to clinical decisions in patients who present with cardiogenic shock, and whether such support can improve their outcomes. We retrospectively reviewed cases of patients who had Impella 5.0 support at our hospital from August 2017 through May 2019. Thirty-four patients (23 with cardiogenic shock and 11 with severely decompensated heart failure) underwent sustained support for a mean duration of 11.7 ± 9.3 days (range, ≀48 d). Of 29 patients (85.3%) who survived to next therapy, 15 were weaned from the Impella, 8 underwent durable left ventricular assist device placement, 4 were escalated to venoarterial extracorporeal membrane oxygenation support, and 2 underwent heart transplantation. The 30-day survival rate was 76.5% (26 of 34 patients). Only 2 patients had a major adverse event: one each had an ischemic stroke and flail mitral leaflet. None of the devices malfunctioned. Sustained hemodynamic support with the Impella 5.0 not only improved outcomes in patients who presented with cardiogenic shock, but also provided time for multidisciplinary evaluation of potential cardiac recovery, or the need for durable left ventricular assist device implantation or heart transplantation. Our study shows the value of using the Impella 5.0 as a bridge to clinical decisions

    G(2) quivers

    Get PDF
    We present, in explicit matrix representation and a modernity befitting the community, the classification of the finite discrete subgroups of G2 and compute the McKay quivers arising therefrom. Of physical interest are the classes of Script N = 1 gauge theories descending from M-theory and of mathematical interest are possible steps toward a systematic study of crepant resolutions to smooth G2 manifolds as well as generalised McKay Correspondences. This writing is a companion monograph to hep-th/9811183 and hep-th/9905212, wherein the analogues for Calabi-Yau three- and four-folds were considered

    Progressive Supranuclear palsy (PSP) disease progression, management, and healthcare resource utilization: a retrospective observational study in the US and Canada

    Get PDF
    Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative brain disease with rapid progression and currently limited treatment options. A comprehensive understanding of disease progression, management, and healthcare resource utilization is limited, and further research is challenging due to the small population of patients. To address these challenges in conducting PSP research, individuals with PSP were recruited using a multichannel approach tailored specifically to the PSP community. We performed a retrospective observational study using data abstracted from participant medical records collected from multiple patient care centers.Results Seventy-two individuals with PSP were eligible for inclusion. On average, 144 medical documents per participant were collected from an average of 2.9 healthcare centers per participant, with a mean study period of 7.9 years. Among participants with a date of symptom onset documented in the medical records, the median time for the onset of the first fall was 2.0 years (IQR 3.2) before diagnosis, the median onset of unsteady gait or gait impairment was 1.2 years (IQR 1.8) before diagnosis, and the median onset of mobility problems was 0.8 years (IQR 1.8) before diagnosis. The most widely utilized healthcare resources, with at least 85% of participants using each of these resources at some point during the disease course, were medications (100%), imaging (99%), assistive devices (90%), supportive care (86%), and surgeries and procedures (85%). Conclusions This retrospective study adds to the current understanding of PSP symptoms, comorbidities, and healthcare resource utilization (HRU) across the disease journey. By involving individuals with PSP and their caregivers or legally authorized representatives in the research process, this study was unique in its approach to participant recruitment and enabled individuals to participate in research without the need for travel. We collected medical documents from multiple healthcare centers, allowing for broad data collection covering the entire disease journey. This approach to the collection of real-world data may be used to generate valuable insights into many aspects of disease progression and management in PSP and many other rare diseases

    Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

    Get PDF
    Partial agonists of the dopamine D2 receptor (D2R) have been developed to treat the symptoms of schizophrenia without causing the side effects elicited by antagonists. The receptor-ligand interactions that determine the intrinsic efficacy of such drugs, however, are poorly understood. Aripiprazole has an extended structure comprising a phenylpiperazine primary pharmacophore and a 1,2,3,4-tetrahydroquinolin-2-one secondary pharmacophore. We combined site-directed mutagenesis, analytical pharmacology, ligand fragments and molecular dynamics simulations to identify the D2R-aripiprazole interactions that contribute to affinity and efficacy. We reveal that an interaction between the secondary pharmacophore of aripiprazole and a secondary binding pocket defined by residues at the extracellular portions of transmembrane segments 1, 2 and 7 determine the intrinsic efficacy of aripiprazole. Our findings reveal a hitherto unappreciated mechanism through which to fine-tune the intrinsic efficacy of D2R agonists
    • 

    corecore