Genotypic association of 5 SNPs in Study 3

<p>Genotypic association of 5 SNPs in Study 3</p

Twenty four SNPs associated with MI in Study 1 and Study 2

*<p>1 sided P value</p

Risk factors for MI in three case–control studies

†<p>Data available for 254 cases.</p>‡<p>Individuals with diabetes were excluded from control group.</p>§<p>Dyslipidemia was defined in Study 1 and Study 2 to be self-reported history of a physician diagnosis of dyslipidemia or the use of lipid lowering prescription medication(s) and defined in Study 3 to be the use of lipid lowering prescription medication(s), LDL cholesterol >129 mg/dL, triglycerides >149 mg/dL or HDL cholesterol <45 mg/dL .</p>||<p>Hypertension was defined in Study 1 and Study 2 to be a self–reported history of a physician diagnosis of hypertension or use of antihypertensive prescription medication(s) and defined in Study 3 to be the use of antihypertensive prescription medication(s), systolic blood pressure >160 mmHg, or diastolic blood pressure >90 mmHg.</p><p>NA; not applicable.</p

Association of the SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection or Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Association of two SNPs in <i>FBN-1</i> with Non-dissecting Thoracic Aortic Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Characteristics of Dissection, Non-dissecting Aneurysm Cases, and Controls.

<p>*P value for Dissection cases vs. controls;</p>†<p>P value for Non-dissecting aneurysm cases vs. controls.</p><p>Data presented as mean ± standard deviation for age and as a number (%) of subjects for other variables.</p><p><i>P</i> values are from Fisher exact test, except those for age, which are from the Wilcoxon rank sum test.</p

Association of two SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Risk reduction according to genotype for rs13279522.

<p>Risk estimate and 95% confidence intervals are indicated for each genotype group in each study, as well as for the combined analysis of the studies. The number of individuals in each group is indicated.</p

P-values from a combined case-only analysis of CARE and WOSCOPS.

<p>Panel A: A Manhattan plot of the P values from the combined case-only analysis of CARE and WOSCOPS. The x-axis corresponds to the chromosomal position for 22 chromosomes and the X chromosome. The Y axis corresponds to the negative base 10 logarithm of the P value. The red line indicates P = 10⁻⁴ and SNPs above this line are indicated in blue. Gene symbols are indicated above loci with P<10^-5 in the combined analysis of CARE and WOSCOPS. The location of DNAJC5B is also indicated. Panel B: A quantile-quantile plot of the observed vs. expected P values. The black lines indicate the 95% CI associated with the expectation that, under the hypothesis of no association, the values will fall on the red diagonal.</p

Baseline characteristics of study participants.

<p>± values are standard deviation.</p