17 research outputs found

    Functional annotation networks consisting of biological pathways enriched with TWAS genes for UF.

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    (A) Four major clusters grouped into three parental biological pathways were enriched with positively associated TWAS genes (TWAS P-value 0). (B) Four major clusters of biological pathways were enriched with negatively associated TWAS genes (TWAS P-value < 0.05 and Z-score < 0). The major clusters are the sub-networks in the top 25% for connectivity score as calculated by the MCODE in each functional annotation network. Each node represented by a pie chart indicates an enriched biological pathway, and the sector size is proportional to the number of genes that originate from each tissue panel. The node size corresponds to the number of panels where TWAS genes were enriched.</p

    A list of five toxic chemicals discovered based on CTD as potentially toxic chemicals for UF.

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    A list of five toxic chemicals discovered based on CTD as potentially toxic chemicals for UF.</p

    A list of significant TWAS genes associated with UF (P < 1.90 × 10<sup>−6</sup>).

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    A list of significant TWAS genes associated with UF (P −6).</p

    Manhattan plots of the UF GWAS summary statistics data analyzed and visualized by FUMA.

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    (A) A Manhattan plot of the input GWAS summary statistics. (B) A Manhattan plot of the MAGMA results. Significant prioritized genes associated with SNPs are visualized with gene symbols. The dashed red line indicates a Bonferroni significant threshold (P −6). (TIF)</p

    A Manhattan plot of the TWAS results for UF.

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    Each dot corresponds to the gene of which predicted expression is associated with UF. The X-axis denotes the chromosome numbers of the genes and the Y-axis denotes −log10(TWAS P-values). The yellow line indicates a Bonferroni significant threshold (P −6). Nine significant TWAS genes are represented as red dots with gene labels.</p
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