Probing the dusty stellar populations of the Local Volume Galaxies with JWST/MIRI

The Mid-Infrared Instrument (MIRI) for the {\em James Webb Space Telescope} (JWST) will revolutionize our understanding of infrared stellar populations in the Local Volume. Using the rich {\em Spitzer}-IRS spectroscopic data-set and spectral classifications from the Surveying the Agents of Galaxy Evolution (SAGE)-Spectroscopic survey of over a thousand objects in the Magellanic Clouds, the Grid of Red supergiant and Asymptotic giant branch star ModelS ({\sc grams}), and the grid of YSO models by Robitaille et al. (2006), we calculate the expected flux-densities and colors in the MIRI broadband filters for prominent infrared stellar populations. We use these fluxes to explore the {\em JWST}/MIRI colours and magnitudes for composite stellar population studies of Local Volume galaxies. MIRI colour classification schemes are presented; these diagrams provide a powerful means of identifying young stellar objects, evolved stars and extragalactic background galaxies in Local Volume galaxies with a high degree of confidence. Finally, we examine which filter combinations are best for selecting populations of sources based on their JWST colours.Comment: 16 pages, 7 figures, 2 online tables; accepted for publication in Ap

Near-Infrared Stellar Populations in the metal-poor, Dwarf irregular Galaxies Sextans A and Leo A

We present JHK$_{s}$ observations of the metal-poor ([Fe/H] $<$ -1.40) Dwarf-irregular galaxies, Leo A and Sextans A obtained with the WIYN High-Resolution Infrared Camera at Kitt Peak. Their near-IR stellar populations are characterized by using a combination of colour-magnitude diagrams and by identifying long-period variable stars. We detected red giant and asymptotic giant branch stars, consistent with membership of the galaxy's intermediate-age populations (2-8 Gyr old). Matching our data to broadband optical and mid-IR photometry we determine luminosities, temperatures and dust-production rates (DPR) for each star. We identify 32 stars in Leo A and 101 stars in Sextans A with a DPR $>10^{-11}$ $M_\odot \,{\rm yr}^{-1}$, confirming that metal-poor stars can form substantial amounts of dust. We also find tentative evidence for oxygen-rich dust formation at low metallicity, contradicting previous models that suggest oxygen-rich dust production is inhibited in metal-poor environments. The total rates of dust injection into the interstellar medium of Leo A and Sextans A are (8.2 $\pm$ 1.8) $\times 10^{-9}$ $M_\odot \,{\rm yr}^{-1}$ and (6.2 $\pm$ 0.2) $\times 10^{-7}$ $M_\odot \,{\rm yr}^{-1}$, respectively. The majority of this dust is produced by a few very dusty evolved stars, and does not vary strongly with metallicity.Comment: 21 pages, 11 figures, 10 tables; accepted for publication in Ap

The star-forming complex LMC-N79 as a future rival to 30 Doradus

Within the early Universe, `extreme' star formation may have been the norm rather than the exception. Super Star Clusters (SSCs; $M_\star$ $\gtrsim$ 10$^5$ M$_\odot$) are thought to be the modern-day analogs of globular clusters, relics of a cosmic time ($z$ $\gtrsim$ 2) when the Universe was filled with vigorously star-forming systems. The giant HII region 30 Doradus in the Large Magellanic Cloud (LMC) is often regarded as a benchmark for studies of extreme star formation. Here, we report the discovery of a massive embedded star forming complex spanning $\sim$ 500 pc in the unexplored southwest region of the LMC, which manifests itself as a younger, embedded twin of 30 Doradus. Previously known as N79, this region has a star formation efficiency exceeding that of 30 Doradus by a factor of $\sim$ 2 as measured over the past $\lesssim$ 0.5 Myr. Moreover, at the heart of N79 lies the most luminous infrared (IR) compact source discovered with large-scale IR surveys of the LMC and Milky Way, possibly a precursor to the central SSC of 30 Doradus, R136. The discovery of a nearby candidate SSC may provide invaluable information to understand how extreme star formation proceeds in the current and high-redshift Universe.Comment: Nature Astronomy, published online 2nd of October 201

Smartphone-Based Prenatal Education for Parents with Preterm Birth Risk Factors

Objective To develop an educational mobile application (app) for expectant parents diagnosed with risk factors for premature birth. Methods Parent and medical advisory panels delineated the vision for the app. The app helps prepare for preterm birth. For pilot testing, obstetricians offered the app between 18–22 weeks gestational age to English speaking parents with risk factors for preterm birth. After 4 weeks of use, each participant completed a questionnaire. The software tracked topics accessed and duration of use. Results For pilot testing, 31 participants were recruited and 28 completed the questionnaire. After app utilization, participants reported heightened awareness of preterm birth (93%), more discussion of pregnancy or prematurity issues with partner (86%), increased questions at clinic visits (43%), and increased anxiety (21%). Participants reported receiving more prematurity information from the app than from their healthcare providers. The 15 participants for whom tracking data was available accessed the app for an average of 8 h. Conclusion Parents with increased risk for preterm birth may benefit from this mobile app educational program. Practice implications If the pregnancy results in preterm birth hospitalization, parents would have built a foundation of knowledge to make informed medical care choices

The Spectra of T Dwarfs I: Near-Infrared Data and Spectral Classification

We present near-infrared spectra for a sample of T dwarfs, including eleven new discoveries made using the Two Micron All Sky Survey. These objects are distinguished from warmer (L-type) brown dwarfs by the presence of methane absorption bands in the 1--2.5 \micron spectral region. A first attempt at a near-infrared classification scheme for T dwarfs is made, based on the strengths of CH$_4$ and H$_2$O bands and the shapes of the 1.25, 1.6, and 2.1 \micron flux peaks. Subtypes T1 V through T8 V are defined, and spectral indices useful for classification are presented. The subclasses appear to follow a decreasing T$_{eff}$ scale, based on the evolution of CH$_4$ and H$_2$O bands and the properties of L and T dwarfs with known distances. However, we speculate that this scale is not linear with spectral type for cool dwarfs, due to the settling of dust layers below the photosphere and subsequent rapid evolution of spectral morphology around T$_{eff}$ $\sim$ 1300--1500 K. Similarities in near-infrared colors and continuity of spectral features suggest that the gap between the latest L dwarfs and earliest T dwarfs has been nearly bridged. This argument is strengthened by the possible role of CH$_4$ as a minor absorber shaping the K-band spectra of the latest L dwarfs. Finally, we discuss one peculiar T dwarf, 2MASS 0937+2931, which has very blue near-infrared colors (J-K$_s$ = $-0.89\pm$0.24) due to suppression of the 2.1 \micron peak. The feature is likely caused by enhanced collision-induced H$_2$ absorption in a high pressure or low metallicity photosphere.Comment: 74 pages including 26 figures, accepted by ApJ v563 December 2001; full paper including all of Table 3 may be downloaded from http://www.gps.caltech.edu/~pa/adam/classification ;also see submission 010844

The Mid-infrared Evolution of the FU Orionis Disk

We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer-IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ~14%. We find that this decrease in luminosity occurs only at wavelengths ≾20 μm. In particular, the continuum shortward of the silicate emission complex at 10 μm exhibits a ~12% (~3σ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μm continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ~12–14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential. Multiple stimuli that drive melanoma cell migration have been described, but it is not clear which are responsible for invasion, nor if chemotactic gradients exist in real tumours. In a chamber-based assay for melanoma dispersal, we find that cells migrate efficiently away from one another, even in initially homogeneous medium. This dispersal is driven by positive chemotaxis rather than chemorepulsion or contact inhibition. The principal chemoattractant, unexpectedly active across all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA receptor LPAR1. LPA induces chemotaxis of remarkable accuracy, and is both necessary and sufficient for chemotaxis and invasion in 2-D and 3-D assays. Growth factors, often described as tumour attractants, cause negligible chemotaxis themselves, but potentiate chemotaxis to LPA. Cells rapidly break down LPA present at substantial levels in culture medium and normal skin to generate outward-facing gradients. We measure LPA gradients across the margins of melanomas in vivo, confirming the physiological importance of our results. We conclude that LPA chemotaxis provides a strong drive for melanoma cells to invade outwards. Cells create their own gradients by acting as a sink, breaking down locally present LPA, and thus forming a gradient that is low in the tumour and high in the surrounding areas. The key step is not acquisition of sensitivity to the chemoattractant, but rather the tumour growing to break down enough LPA to form a gradient. Thus the stimulus that drives cell dispersal is not the presence of LPA itself, but the self-generated, outward-directed gradient

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A&gt;T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

Detection of Mitochondrial COII DNA Sequences in Ant Guts as a Method for Assessing Termite Predation by Ants

Termites and ants contribute more to animal biomass in tropical rain forests than any other single group and perform vital ecosystem functions. Although ants prey on termites, at the community level the linkage between these groups is poorly understood. Thus, assessing the distribution and specificity of ant termitophagy is of considerable interest.We describe an approach for quantifying ant-termite food webs by sequencing termite DNA (cytochrome c oxidase subunit II, COII) from ant guts and apply this to a soil-dwelling ant community from tropical rain forest in Gabon. We extracted DNA from 215 ants from 15 species. Of these, 17.2% of individuals had termite DNA in their guts, with BLAST analysis confirming the identity of 34.1% of these termites to family level or better. Although ant species varied in detection of termite DNA, ranging from 63% (5/7; Camponotus sp. 1) to 0% (0/7; Ponera sp. 1), there was no evidence (with small sample sizes) for heterogeneity in termite consumption across ant taxa, and no evidence for species-specific ant-termite predation. In all three ant species with identifiable termite DNA in multiple individuals, multiple termite species were represented. Furthermore, the two termite species that were detected on multiple occasions in ant guts were in both cases found in multiple ant species, suggesting that anttermite food webs are not strongly compartmentalised. However, two ant species were found to consume only Anoplotermes-group termites, indicating possible predatory specialisation at a higher taxonomic level. Using a laboratory feeding test, we were able to detect termite COII sequences in ant guts up to 2 h after feeding, indicating that our method only detects recent feeding events. Our data provide tentative support for the hypothesis that unspecialised termite predation by ants is widespread and highlight the use of molecular approaches for future studies of ant-termite food webs