Strategies to Improve the Use of Live Synchronous Meetings in Blended, Remote, and Online Courses

Distance education over the years has been defined by the ability of students to learn at any time, from anywhere. Thus, it is not surprising that most online courses rely solely on asynchronous text-based online communication, such as email and discussion forums. However, the COVID- 19 pandemic and the rise of emergency remote teaching have sparked an increased interest in using web conferencing software (e.g., Zoom, WebEx, Google Meet, Microsoft Teams) to hold live synchronous meetings, often on a set day and time each week, instead of asynchronous discussions. But as convenient as it can be to move classroom instruction to live synchronous meetings, instructors and students have quickly experienced some drawbacks to using this mode of instruction. Given this problem, we set out to curate a list of strategies to improve the use of live synchronous meetings based on the literature and our combined experience designing and teaching online over the years. In this paper, we describe some affordances and constraints of live synchronous meetings and then describe some strategies that instructors can use to improve their use of these meetings, whether that be in a blended, remote, or online course

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.

Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that promote cellular proliferation and survival. Previous studies have demonstrated antitumor activity of CS3D in preclinical models of solid tumors. However, prior to entering human clinical trials, the efficiency of generating the CS3D molecule and its stability in biological fluids should be determined. CS3D is synthesized as a single-stranded ODN and must have its free ends ligated to generate the final cyclic form. In this study, we report a ligation efficiency of nearly 95 percent. The ligated CS3D demonstrated a half-life of 7.9 h in human serum, indicating adequate stability for intravenous delivery. These results provide requisite biochemical characterization of CS3D that will inform upcoming clinical trials

Hijacking Journalism: Legitimacy and Metajournalistic Discourse in Right-Wing Podcasts

Whereas personal expression has become a core practice of journalism whose merits can include greater attention to context and interpretative analysis, these freedoms from the constraints of traditional broadcast conventions can pose serious risks, including the ideological hijacking of journalism by partisan actors. In popular right-wing podcasts, such as those hosted by Ben Shapiro and Dan Bongino, the element of opinion amplifies the tendency of the podcast medium to relegate news to a secondary concern behind the emotional impact. Not only do podcasters like Shapiro and Bongino contribute to a fractured media environment of hyper-partisan news and commentary, but they also utilize social media platforms and transmedia networks to undermine traditional journalism and replace it with an alternative conservative media ecosystem - a multiplatform, full-service clearinghouse of news and commentary afforded by the publishing capabilities of the internet and the distribution algorithms of social media platforms like Facebook. This study charts the evolution of conservative audio production, from the influential work of talk radio star Rush Limbaugh through the latest innovations by conservative podcasters, as exemplified by Shapiro and Bongino. Our study builds on previous scholarship on metajournalistic discourse to examine how right-wing podcasters use exclusionary language to delegitimize the institution of journalism and offer a self-contained, ideologically conservative version of journalism as a replacement

Point containment algorithms for constructive solid geometry with unbounded primitives

We present several algorithms for evaluating point containment in constructive solid geometry (CSG) trees with unbounded primitives. Three algorithms are presented based on postfix, prefix, and infix notations of the CSG binary expression tree. We show that prefix and infix notations enable short-circuiting logic, which reduces the number of primitives that must be checked during point containment. To evaluate the performance of the algorithms, each algorithm was implemented in the OpenMC Monte Carlo particle transport code, which relies on CSG to represent solid bodies through which subatomic particles travel. Two sets of tests were carried out. First, the execution time to generate a high-resolution rasterized image of a 2D slice of a detailed CSG model of the ITER tokamak was measured. Use of both prefix and infix notations offered significant speedup over the postfix notation that has traditionally been used in particle transport codes, with infix resulting in a 6$\times$ reduction in execution time relative to postfix. We then measured the execution time of neutron transport simulations of the same ITER model using each of the algorithms. The results and performance improvements reveal the same trends as for the rasterization test, with a 4.59$\times$ overall speedup using the infix notation relative to the original postfix notation in OpenMC

Aligning assessment with the needs of work-integrated learning: the challenges of authentic assessment in a complex context

Work-integrated learning (WIL) is a feature of university courses, both in professional areas, where it is commonplace, but also across many different disciplines. Assessment of WIL can be complex as it involves parties and settings external to the university, and it can be problematic because of difficulties in aligning learning activities during placements with what is or can be assessed by the university. This paper explores the relationship between students’ placement experiences and accompanying assessments in contexts where activities are tightly coupled with the curriculum, and in those where it is not. It draws on a qualitative analysis of student interviews and drawings by the interviewees of their WIL experiences, supplemented with analysis of unit guides. Our findings highlight that students’ perceptions of authenticity of assessment were undermined by misalignments between the student, university and industry. Assessment authenticity was perceived by students as based on alignment between their current and future selves in the assessment process, involvement of industry supervisors and relevance of placement activities to assessment activities. The paper discusses the complexity of coordination of educational activities with external partners, especially when one party drives assessment. It then suggests a reframing of WIL assessment to promote alignment and authenticity

Projected seniority-two orbital optimization of the Antisymmetric Product of one-reference orbital Geminal

We present a new, non-variational orbital-optimization scheme for the Antisymmetric Product of one-reference orbital Geminal wave function. Our approach is motivated by the observation that an orbital-optimized seniority-zero configuration interaction (CI) expansion yields similar results to an orbital-optimized seniority-zero-plus-two CI expansion [J. Chem. Phys., 135, 044119 (2011)]. A numerical analysis is performed for the C$_2$, LiF and CH$_2$ molecules as well as for the symmetric stretching of hypothetical (linear) hydrogen chains. For these test cases, the proposed orbital-optimization protocol yields similar results to its variational orbital optimization counterpart, but prevents symmetry-breaking of molecular orbitals in most cases.Comment: 7 pages, 2 figure

Multi-Player Quantum Games

Recently the concept of quantum information has been introduced into game theory. Here we present the first study of quantum games with more than two players. We discover that such games can possess a new form of equilibrium strategy, one which has no analogue either in traditional games or even in two-player quantum games. In these `pure' coherent equilibria, entanglement shared among multiple players enables new kinds of cooperative behavior: indeed it can act as a contract, in the sense that it prevents players from successfully betraying one-another.Comment: 5 pages, 2 figs. Substantial revisons inc. new result