Sharing data from clinical trials: the rationale for a controlled access approach.

The move towards increased transparency around clinical trials is welcome. Much focus has been on under-reporting of trials and access to individual patient data to allow independent verification of findings. There are many other good reasons for data sharing from clinical trials. We describe some key issues in data sharing, including the challenges of open access to data. These include issues in consent and disclosure; risks in identification, including self-identification; risks in distorting data to prevent self-identification; and risks in analysis. These risks have led us to develop a controlled access policy, which safeguards the rights of patients entered in our trials, guards the intellectual property rights of the original researchers who designed the trial and collected the data, provides a barrier against unnecessary duplication, and ensures that researchers have the necessary resources and skills to analyse the data

Heterogeneity of wheat endosperm proteolipids (CM proteins)

Proteins extracted with CHCl3-MeOH from wheat endosperm have been fractionated by Sephadex G-100 and the 15 000–20 000 MW range fraction, designated CM protein, has been examined by combined electrofocusing (pH range 5–8) and electrophoresis (pH 3.2) and the heterogeneity of the electrophoretic components has been ascertained. It has been shown by joint mapping and by sequential extraction that CM proteins are extracted by 70% EtOH but not by H2O, although they can be made water-soluble after dialysis against an acid buffer, pH 3.2, 3 M urea, without losing their solubility in CHCl3-MeOH mixtures. It is concluded that CM proteins fit the definition of a Folch—Lees proteolipid. The Triticum aestivum (genomes ABD) map can be reconstructed by mixing T. durum (AB) and Aegilops squarrosa (D). The low intragenomic variability of CM protein is confirmed

Motivational interviewing for vaccine hesitant parents

BACKGROUND: The widespread use of vaccines led to significant decline in multiple potentially fatal infectious diseases. Recently, there has been an increase in vaccine hesitancy. Measles and pertussis outbreaks throughout the United States have put a spotlight on this urgent healthcare issue. Motivational interviewing is a counseling tactic that is gaining popularity and is being studied for its efficacy in preventative medicine and psychological disorders. It aims to inspire people to make behavioral changes through collaborative relationships with their provider by understanding how current actions do not translate into their health goals. LITERATURE REVIEW FINDINGS: Vaccine hesitancy is growing. Communities with decreased immunization rates are associated with a higher risk of disease outbreak. Increasing rates of undervaccinated children are likely due to increases in non-medical exemptions. Many parents, regardless of their vaccine hesitancy status, are concerned about vaccine safety. Vaccine hesitant parents refuse vaccines due to philosophical and religious beliefs, conspiracy theories, and safety concerns. Parents feel that providers do not adequately address their concern. Providers report not having the training to discredit parental concerns. The majority of parents describe their child’s pediatrician as their most trusted source of vaccine information. Parents who receive vaccine information from a provider are more likely to comply with the recommended childhood vaccine schedule. The most efficient way to discuss vaccines with parents has yet to be determined. PROPOSED PROJECT: This is a proposed QI research project for the Pediatric Clinic at Boston Medical Center. Providers would be trained in motivational interviewing during several sessions that included lectures and small group practice sessions with systematic feedback. During the intervention, parents who refuse vaccines for their child, aged 0-6 years old, will receive motivational interviewing from the provider. The proportion of the vaccine hesitant parents who accept the offered vaccine after will be analyzed. The pre and post intervention vaccination rates for the entire clinic will also be assessed. Data collection will be preformed through retrospective chart review. The project aims to increase provider confidence on vaccine counseling, educate providers on reasons for hesitancy, and improve compliance with the CDC recommended vaccine schedule. CONCLUSION: While most Americans continue to vaccinate their children according to the CDC’s recommended schedule, constant vigilance is required to maintain high immunization rates to protect our communities. Motivational interviewing is goal-oriented to alter a specific behavior and would allow providers to engage in an open, persuasive dialogue about parental vaccine concerns

Form Regulation to Address New Construction in Historic Districts

This thesis will evaluate several tools that cities are currently using to regulate the form of new construction, large alterations, and additions in designated historic areas. A number of tools are available to achieve this type of regulation, but the most popular tools tend to be place-specific design guidelines derived from the study of a historic district, associated with an overlay designation established by the city’s zoning code. Throughout this thesis, this type of regulation will be referred to as “traditional tools.” “Non-traditional tools,” as used herein, include things like form-based codes or neighborhood conservation districts. These are tools that have not been as widely used or are relatively new to the regulatory landscape. The tools evaluated in this thesis will be examined through case studies and include a mix of traditional tools and non-traditional tools. The traditional tool case studies are New Orleans, LA, and Savannah, GA. The non-traditional tool case studies are Beaufort, SC, which is used a case study for both traditional and nontraditional tools, and Philadelphia, PA

The seasonal cycle of ocean-atmosphere CO2 Flux in Ryder Bay, West Antarctic Peninsula

Approximately 15 million km2 of the Southern Ocean is seasonally ice covered, yet the processes affecting carbon cycling and gas exchange in this climatically important region remain inadequately understood. Here, 3 years of dissolved inorganic carbon (DIC) measurements and carbon dioxide (CO2) fluxes from Ryder Bay on the west Antarctic Peninsula (WAP) are presented. During spring and summer, primary production in the surface ocean promotes atmospheric CO2 uptake. In winter, higher DIC, caused by net heterotrophy and vertical mixing with Circumpolar Deep Water, results in outgassing of CO2 from the ocean. Ryder Bay is found to be a net sink of atmospheric CO2 of 0.59–0.94 mol C m−2 yr−1 (average of 3 years). Seasonal sea ice cover increases the net annual CO2 uptake, but its effect on gas exchange remains poorly constrained. A reduction in sea ice on the WAP shelf may reduce the strength of the oceanic CO2 sink in this region

Sexualization, Sex Discrimination, and Public School Dress Codes

This essay joins the conversation about sexualization, sex discrimination, and public school dress codes to situate current debates within in the broader cultural and legal landscapes in which they exist. My aim is not to answer definitively the questions I pose above. Rather, I ground the controversy in these broader contexts in order to better understand the stakes and to glean insights into how schools, students, and communities might better navigate dress code debates

The Effect of Hot Fill and Hold Processing on the Performance of Multilayer Packaging Films

Heat transfer in thermal processing is crucial to ensure all parts of a product are sufficiently treated to achieve commercial sterility without unacceptable loss of quality. Optimizing pasteurization methods is recommended to preserve quality attributes such as color, texture, and flavor while maintaining food safety integrity. This research evaluated the temperature variability in pouches during a hot fill and hold process and the effect of those identified differences on color quality of a tomato based food simulant. The performance of multilayer films for pasteurized products in accelerated storage conditions were also studied. The research project was separated into two phases. The objective of the first phase was to understand the profiles of heating and cooling in pouches processed in a simulated hot fill and hold process. The corners of the pouch were found to be the fastest cooling spot within the pouch (p\u3c0.05). The center of the pouch was found to have the highest mean temperature during the hold step of the process and had the slowest cooling rate in the pouch (p\u3c0.05). The trends of heating and cooling were also evaluated using a low viscosity food simulant. This study compared the time and temperature profiles for a static hot fill process versus a process that incorporated rotating the pouch 180° every 10 seconds. For the static hot fill and hold process, mean temperatures of the center and corners of a pouch showed non-uniform heat transfer during the holding period and cooling process. More uniform heating and cooling within pouches was achieved by implementing 180° rotation during processing