Recasting Economics as if the Climate and Global Ecology Really Mattered

Peer reviewedPublisher PD

On Using Gait in Forensic Biometrics

Given the continuing advances in gait biometrics, it appears prudent to investigate the translation of these techniques for forensic use. We address the question as to the confidence that might be given between any two such measurements. We use the locations of ankle, knee and hip to derive a measure of the match between walking subjects in image sequences. The Instantaneous Posture Match algorithm, using Harr templates, kinematics and anthropomorphic knowledge is used to determine their location. This is demonstrated using real CCTV recorded at Gatwick Airport, laboratory images from the multi-view CASIA-B dataset and an example of real scene of crime video. To access the measurement confidence we study the mean intra- and inter-match scores as a function of database size. These measures converge to constant and separate values, indicating that the match measure derived from individual comparisons is considerably smaller than the average match measure from a population

Mitochondrial DNA Deletions and ROS Scavengers

poster abstractThe purpose of this experiment is to observe how deletion of genes that are involved in the electron transport chain cause mitochondrial damage and an increase in reactive oxygen species and if antioxidants could minimize the effects of oxidation. Saccharomyces cerevisiae is ideal for this study as it is used for research with chronological aging. Chronological aging is the survival during the stationary phase after nutrients and space becomes limited and has been used to study neurons in the central nervous system, oxidative stress, and changes in morphology. Deletions of mitochondrial DNA and the increase of reactive oxygen species over time has been linked to a decline in the production of ROS scavengers. ROS scavengers serve as a defense against the oxidation of various cells by neutralizing the reactive oxygen species. These include antioxidants such as Vitamin-C, Vitamin-E, and flavonoids. For this experiment, genes from the yeast Saccharomyces cerevisiae will be removed using gene knockout, which will inactivate the genes of interest. The genes of interest are Cox 1, 2, 3, 5a, 12, 23 and SOD 1 (Superoxide Dismutase) and 2, OPA 1, and Atg32. These genes are important in the electron transport chain, fission, fusion, and mitophagy. The mutated yeast will then be placed into a ROS scavenger media containing Vitamin-C and incubated overnight. Assays that will be used include Rhodamine 123 which determines membrane potential and proton flow from the inner membrane to the matrix, Janus Green which reveals alterations in the electron transport chain and amount of oxygen available, Cytochrome c Oxidase assay which can determine cytochrome c activity and outer membrane stress, and dihydrorhodamine to indicate ROS levels. Using fluorescent dyes such as Rhodamine 123 will allow the cells to be observe through a microscope and observe the amount of damage and fission that has been produced by the mutations and the effects of the antioxidants on the destruction of the mutated cells

The SPARC Data Initiative: comparisons of CFC-11, CFC-12, HF and SF6 climatologies from international satellite limb sounders

A quality assessment of the CFC-11 (CCl3F), CFC-12 (CCl2F2), HF, and SF6 products from limb-viewing satellite instruments is provided by means of a detailed intercomparison. The climatologies in the form of monthly zonal mean time series are obtained from HALOE, MIPAS, ACE-FTS, and HIRDLS within the time period 1991–2010. The intercomparisons focus on the mean biases of the monthly and annual zonal mean fields and aim to identify their vertical, latitudinal and temporal structure. The CFC evaluations (based on MIPAS, ACE-FTS and HIRDLS) reveal that the uncertainty in our knowledge of the atmospheric CFC-11 and CFC-12 mean state, as given by satellite data sets, is smallest in the tropics and mid-latitudes at altitudes below 50 and 20 hPa, respectively, with a 1σ multi-instrument spread of up to ±5 %. For HF, the situation is reversed. The two available data sets (HALOE and ACE-FTS) agree well above 100 hPa, with a spread in this region of ±5 to ±10 %, while at altitudes below 100 hPa the HF annual mean state is less well known, with a spread ±30 % and larger. The atmospheric SF6 annual mean states derived from two satellite data sets (MIPAS and ACE-FTS) show only very small differences with a spread of less than ±5 % and often below ±2.5 %. While the overall agreement among the climatological data sets is very good for large parts of the upper troposphere and lower stratosphere (CFCs, SF6) or middle stratosphere (HF), individual discrepancies have been identified. Pronounced deviations between the instrument climatologies exist for particular atmospheric regions which differ from gas to gas. Notable features are differently shaped isopleths in the subtropics, deviations in the vertical gradients in the lower stratosphere and in the meridional gradients in the upper troposphere, and inconsistencies in the seasonal cycle. Additionally, long-term drifts between the instruments have been identified for the CFC-11 and CFC-12 time series. The evaluations as a whole provide guidance on what data sets are the most reliable for applications such as studies of atmospheric transport and variability, model–measurement comparisons and detection of long-term trends. The data sets will be publicly available from the SPARC Data Centre and through PANGAEA (doi:10.1594/PANGAEA.849223)

Experimental micromechanical characterisation of wood cell walls

International audienceThe properties of wood and wood based materials are strongly dependent on the properties of its fibres; i.e. the cell wall properties. The ability to characterize these in order to increase our understanding of structure-property relationships is thus highly important. This article gives a brief overview of the state of the art in experimental techniques to characterize the mechanical properties of wood at both the level of the single cell and that of the cell-wall. Challenges, opportunities, drawbacks and limitations of single fibre tensile tests and nanoindentation are discussed with respect to the wood material properties

Self-Management Support to People with Type 2 Diabetes - A comparative study of Kaiser Permanente and the Danish Healthcare System

BACKGROUND: Self-management support is considered to be an essential part of diabetes care. However, the implementation of self-management support within healthcare settings has appeared to be challenging and there is increased interest in “real world” best practice examples to guide policy efforts. In order to explore how different approaches to diabetes care and differences in management structure influence the provision of SMS we selected two healthcare systems that have shown to be comparable in terms of budget, benefits and entitlements. We compared the extent of SMS provided and the self-management behaviors of people living with diabetes in Kaiser Permanente (KP) and the Danish Healthcare System (DHS). METHODS: Self-administered questionnaires were used to collect data from a random sample of 2,536 individuals with DM from KP and the DHS in 2006–2007 to compare the level of SMS provided in the two systems and identify disparities associated with educational attainment. The response rates were 75 % in the DHS and 56 % in KP. After adjusting for gender, age, educational level, and HbA1c level, multiple linear regression analyses determined the level of SMS provided and identified disparities associated with educational attainment. RESULTS: Receipt of SMS varied substantially between the two systems. More people with diabetes in KP reported receiving all types of SMS and use of SMS tools compared to the DHS (p < .0001). Less than half of all respondents reported taking diabetes medication as prescribed and following national guidelines for exercise. CONCLUSIONS: Despite better SMS support in KP compared to the DHS, self-management remains an under-supported area of care for people receiving care for diabetes in the two health systems. Our study thereby suggests opportunity for improvements especially within the Danish healthcare system and systems adopting similar SMS support strategies

Twenty questions about design behavior for sustainability, report of the International Expert Panel on behavioral science for design

How behavioral scientists, engineers, and architects can work together to advance how we all understand and practice design—in order to enhance sustainability in the built environment, and beyond.https://www.nature.com/documents/design_behavior_for_sustainability.pdfPublished versio

Incorporating translation into sociolinguistic research: translation policy in an international non-governmental organisation

This article explores aspects of translation, multilingualism and language policy in the field of transnational civil society. By focusing on translation policies at Amnesty International, an international non-governmental organisation that performs a key role in global governance, this article seeks to contribute to a globalisation-sensitive sociolinguistics. It argues that combining a sociolinguistic approach, more precisely linguistic ethnography, with translation studies leads to an increased understanding of the language practices under study. Furthermore, the article calls for more interdisciplinary research, stating that there is a space for sociolinguistics and translation studies to contribute to research in international relations and development studies by highlighting the role of multilingualism and challenging the traditionally powerful position of English in transnational civil society

BNip3 regulates mitochondrial function and lipid metabolism in the liver

BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from fed mice, we have shown that its expression is superinduced by fasting of mice, consistent with a role in responses to nutrient deprivation. Loss of BNip3 resulted in increased lipid synthesis in the liver that was associated with elevated ATP levels, reduced AMP-regulated kinase (AMPK) activity, and increased expression of lipogenic enzymes. Conversely, there was reduced β-oxidation of fatty acids in BNip3 null liver and also defective glucose output under fasting conditions. These metabolic defects in BNip3 null liver were linked to increased mitochondrial mass and increased hepatocellular respiration in the presence of glucose. However, despite elevated mitochondrial mass, an increased proportion of mitochondria exhibited loss of mitochondrial membrane potential, abnormal structure, and reduced oxygen consumption. Elevated reactive oxygen species, inflammation, and features of steatohepatitis were also observed in the livers of BNip3 null mice. These results identify a role for BNip3 in limiting mitochondrial mass and maintaining mitochondrial integrity in the liver that has consequences for lipid metabolism and disease