Manoeuvring towards Research Decline: The RAE and the Decline of Britain's International Research Standing

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The Research Evaluation and Gobalization of Business Research

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A Screening Library for Peptide Activated G-Protein Coupled Receptors. 1. The Test Set

One subset of the G-protein coupled receptor (GPCR) superfamily is that which is activated by a peptide carrying an obligatory positively charged residue (GPCR−PA+). This subclass is exemplified by receptors for melanocortins, GnRH, galanin, MCH, orexin, and some chemokine receptors variously involved in eating disorders, reproductive disorders, pain, narcolepsy, obesity, and inflammation. Using the methods described in this study, a region of chemical property space enriched in GPCR ligands was identified. This information was used to design and synthesize a “test” library of 2025 single, pure compounds to sample portions of this property space associated with GPCR−PA+ ligands. The library was evaluated by high-throughput screening against three different receptors, rMCH, hMC4, and hGnRH, and found to be highly enriched in active ligands (4.5−61-fold) compared to a control set of 2024 randomly selected compounds. In addition, the analysis suggested that about 7000 compounds will be necessary to complete the sampling of this GPCR−PA+ ligand-rich region and to better define its borders

Supplemental material for Do healthcare professionals and young adults know about the National Chlamydia Screening Programme? Findings from two cross-sectional surveys

Supplemental material for Do healthcare professionals and young adults know about the National Chlamydia Screening Programme? Findings from two cross-sectional surveys by Susanna Currie, Catherine H Mercer, Kevin J Dunbar, John Saunders and Sarah C Woodhall in International Journal of STD & AIDS</p

The economic costs of weeds on productive land in New Zealand

Here we review published research on the costs of weeds to New Zealand’s pastoral, arable and forestry sectors, and propose an alternative dynamic approach for future research. The studies reviewed had little in common methodologically, often contained guesswork, or were outdated. Their aggregation resulted in a conservative estimate of the cost of weeds to New Zealand’s agricultural economy of $1658 million (2014 NZD). To address deficiencies in previously used methodologies, a dynamic approach is developed and applied to a case study on giant buttercup in dairy pastures. This approach accounts for probable temporal changes in both the geographic extent of the weed and in producer prices and indicates annuitized costs (over the period 2012–2030) of$166 million, $259 million and$592 million for rates of spread of 144, 60 and 20 years for giant buttercup to invade all dairy regions in New Zealand. Comparing the aggregate cost of all weeds to the three productive sectors estimated from the historical data with these ‘dynamic’ estimates for the one species in dairy pasture, indicates that the historical data provide a substantial underestimate of the true aggregate cost of weeds to New Zealand’s agricultural economy

ESEC/FSE 2019 - A Statistics-based Performance Testing Methodology for Cloud Applications

There are the experiment result data sets for ESEC/FSE paper:“A Statistics-based Performance Testing Methodology for Cloud Applications”Including source code and datasetFor details please refer to Install and Readme</div

Additional file 4: of Application of the COM-B model to barriers and facilitators to chlamydia testing in general practice for young people and primary care practitioners: a systematic review

Findings of included studies with young people. (PDF 221 kb

Additional file 2: of Application of the COM-B model to barriers and facilitators to chlamydia testing in general practice for young people and primary care practitioners: a systematic review

Search Strategy for MEDLINE. (PDF 65 kb

Additional file 5: of Application of the COM-B model to barriers and facilitators to chlamydia testing in general practice for young people and primary care practitioners: a systematic review

Illustrative quotes for each theme. (PDF 161 kb

Priority area 8—A BCW analysis of ‘PrEP providers communicate the decision to not provide further PrEP’.

Priority area 8—A BCW analysis of ‘PrEP providers communicate the decision to not provide further PrEP’.</p