CH05-2 Obtaining theoretical estimates of D2 receptor occupancy by antipsychotic agents from administered daily dose

<b>Appendix</b> to:<div>Lataster, J., van Os, J., de Haan, L., Thewissen, V., Bak, M., Lataster, T., ... & Myin-Germeys, I. (2011). Emotional experience and estimates of D2 receptor occupancy in psychotic patients treated with haloperidol, risperidone, or olanzapine: an experience sampling study. <i>The Journal of clinical psychiatry</i>, <i>72</i>(10), 1397-1404.<br></div><div><br></div><div><b>DOI: 10.4088/JCP.09m05466yel</b><br></div

CH01 New perspectives on stress and psychosis - Introduction

<div>Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy.</div><div><br></div><div><b>Abstract</b> Psychotic disorders remain among the most burdensome and intangible mental illnesses worldwide, perturbing the emotional and social life of those affected, and throwing their surrounding environment into great confusion. Although environmental stress has been repeatedly identified as risk factor for psychosis, the imperative aspect of interaction between a vulnerable individual and its stressful surroundings has remained largely disregarded. Using a combination of prospective, population-based studies, ecological sampling, and neuroimaging techniques, the work presented in the current thesis examines how the stressful environment affects the vulnerable individual, and which mechanisms underlie its transition to illness.</div><div><br></div><div>ISBN 978-90-8570-798-1 © 2012 J.J.E. Lataster, Maastricht, the Netherlands. All rights reserved. </div><div>Connecting the dots: new perspectives on stress and psychosis.</div

CH00 New perspectives on stress and psychosis - Title and Table of Contents

Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy. <div><br><div><b>Abstract</b> Psychotic disorders remain among the most burdensome and intangible mental illnesses worldwide, perturbing the emotional and social life of those affected, and throwing their surrounding environment into great confusion. Although environmental stress has been repeatedly identified as risk factor for psychosis, the imperative aspect of interaction between a vulnerable individual and its stressful surroundings has remained largely disregarded. Using a combination of prospective, population-based studies, ecological sampling, and neuroimaging techniques, the work presented in the current thesis examines how the stressful environment affects the vulnerable individual, and which mechanisms underlie its transition to illness.</div><div><br></div><div>ISBN 978-90-8570-798-1 © 2012 J.J.E. Lataster, Maastricht, the Netherlands. All rights reserved. <br><i>Connecting the dots: new perspectives on stress and psychosis.</i></div></div

2010 | Evidence for the behavioral sensitization hypothesis of psychosis (conference presentation, 2010)

see also:<div>Lataster, J., Myin‐Germeys, I., Lieb, R., Wittchen, H. U., & van Os, J. (2012). Adversity and psychosis: a 10‐year prospective study investigating synergism between early and recent adversity in psychosis. <i>Acta psychiatrica scandinavica</i>, <i>125</i>(5), 388-399.<br></div><div><br></div><div><b>DOI: 10.1111/j.1600-0447.2011.01805.x</b><br></div><div><br></div><div>Collip, D., Myin-Germeys, I., & Van Os, J. (2008). Does the concept of “sensitization” provide a plausible mechanism for the putative link between the environment and schizophrenia?. <i>Schizophrenia bulletin</i>, <i>34</i>(2), 220-225.<br></div

CH07 New perspectives on stress and psychosis - Summary & discussion

<div>Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy.</div><div><br></div><div><b>Abstract</b> Psychotic disorders remain among the most burdensome and intangible mental illnesses worldwide, perturbing the emotional and social life of those affected, and throwing their surrounding environment into great confusion. Although environmental stress has been repeatedly identified as risk factor for psychosis, the imperative aspect of interaction between a vulnerable individual and its stressful surroundings has remained largely disregarded. Using a combination of prospective, population-based studies, ecological sampling, and neuroimaging techniques, the work presented in the current thesis examines how the stressful environment affects the vulnerable individual, and which mechanisms underlie its transition to illness.</div><div><br></div><div>ISBN 978-90-8570-798-1 © 2012 J.J.E. Lataster, Maastricht, the Netherlands. All rights reserved. </div

2005 | Visual information and haptic performance: evidence for task- and direction-specific visuo-haptic interactions (Poster @ Endo-Neuro-Psycho Meeting, Doorwerth, The Netherlands, 2005)

for a more detailed report see:<div><br></div><div>Kaas, A. L., van Mier, H. I., Lataster, J., Fingal, M., & Sack, A. T. (2007). The effect of visuo-haptic congruency on haptic spatial matching. <i>Experimental brain research</i>, <i>183</i>(1), 75-85.<br></div><div><br></div><div><b>DOI: 10.1007/s00221-007-1026-9</b></div

2014 | Giving up Crime: Daily-life emotional experience and perceived support in detainees participating in the rehabilitation program ‘Giving up Crime’ (Kiezen voor Verandering) (conference poster, 2014)

The person centered method Giving up Crime (GUC) promotes recovery and desistance from crime in (ex)detainees by capitalizing on personal strengths and stimulating intrinsic goal restructuring. Although GUC is positively evaluated by detainees and prison officers, insight in the mechanisms underlying these appraisals is scant. This study investigates the effects of GUC on detainees´ emotional experience and perceived levels of support in the realm of daily life. (study was performed with permission of The Dutch Custodial Institutions Agency - DJI

CH02 Adversity and psychosis: a 10‐year prospective study investigating synergism between early and recent adversity in psychosis

<div><b>Objective:</b>  Recent studies have suggested that early adverse events, such as childhood trauma, may promote enduring liability for psychosis whereas more recent adverse events may act as precipitants. Examination of these environmental dynamics, however, requires prospective studies in large samples. This study examines whether the association between recent adverse events and psychosis is moderated by exposure to early adversity.</div><div><br></div><div><b>Method:</b>  A random regional representative population sample of 3021 adolescents and young adults in Munich, Germany, was assessed three times over a period of up to 10 years, collecting information on sociodemographic factors, environmental exposures, and measures of psychopathology and associated clinical relevance. Evidence of statistical non-additivity between early adversity (two levels) and more recent adversity (four levels) was assessed in models of psychotic symptoms. Analyses were a priori corrected for age, gender, cannabis use, and urbanicity.</div><div><br></div><div><b>Results:</b>  Early and recent adversity were associated with each other (RR = 1.32, 95% CI 1.06–1.66; P = 0.014) and displayed statistical non-additivity at the highest level of exposure to recent adversity (χ2 = 4.59; P = 0.032).</div><div><br></div><div><b>Conclusion:</b>  The findings suggest that early adversity may impact on later expression of psychosis either by increasing exposure to later adversity and/or by rendering individuals more sensitive to later adversity if it is severe.</div><div><br></div><div>see also:</div><div>Lataster, J., Myin‐Germeys, I., Lieb, R., Wittchen, H. U., & van Os, J. (2012). Adversity and psychosis: a 10‐year prospective study investigating synergism between early and recent adversity in psychosis. <i>Acta psychiatrica scandinavica</i>, <i>125</i>(5), 388-399.<br></div><div><br></div><div><b>DOI: 10.1111/j.1600-0447.2011.01805.x</b><br></div

2018 | Momentary Well-Being at Work: The Role of Relatedness (conference presentation, 2018)

<div><b>Momentary Well-Being at Work: The Role of Relatedness</b></div><div><br></div><div>Marianne van Woerkom(1), Nele Jacobs(2)(3), Sanne Peeters(2)(3), Mayke Janssens(2)(3), Jennifer Reijnders(2), <b>Johan Lataster(2)(3)*</b></div><div> </div><div>1 Department of Human Resource Studies, Tilburg University; Tilburg, The Netherlands</div><div>2 Faculty of Psychology and Educational Sciences, Open University; Heerlen, The Netherlands</div><div>3 Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre; Maastricht, The Netherlands</div><div><b>* presenter</b></div><div><br></div><div>Presented as part of symposium</div><div><b>'Caring Relationships in Organizations: Effects, Antecedents, and Related Mechanisms'</b></div><div>9th European Conference on Positive Psychology, June 27-30th, Budapest, Hungary</div><div><br></div><div>Symposium Chair: Shiri Lavy(4)</div><div> </div><div>4 Department for Leadership and Policy in Education, University of Haifa, Israel</div

CH06 Psychotic exacerbation and emotional dampening in the daily life of patients with schizophrenia switched to aripiprazole therapy: a collection of standardized case reports

<b>Background:</b> Blockade of the dopamine D2 receptor is a key mechanism in the antipsychotic treatment of patients with a psychotic disorder, but may also induce emotional deficits. The partial D2 agonistic profile of aripiprazole has, therefore, been suggested to favor emotional wellbeing compared with the pure dopamine antagonistic properties of traditional antipsychotics. <b>Method:</b> The current study used the experience sampling method (a structured diary technique) to assess the effects of switching from treatment with traditional dopamine antagonist antipsychotics to treatment with the partial dopamine agonist aripiprazole on emotional wellbeing in the daily life of 13 patients with a diagnosis of schizophrenia. <b>Results:</b> More than half of all patients experienced exacerbation of psychotic symptoms after they had switched to the aripiprazole medication regime, consequently resulting in dropout of the study. Furthermore, switching to aripiprazole treatment, when effective in terms of symptom reduction, was accompanied by decreased feelings of both positive and negative affect in daily life, suggestive of a general state of emotional dampening. <b>Conclusions:</b> Although the scale of the current study and the 54% dropout rate call for careful interpretation of the data, implementation of ecological monitoring in psychopharmacological research may open up new avenues for untangling the working mechanisms of compounds with regard to their impact on mental states.<div><br></div><div>see also:</div><div>Lataster, J., Myin-Germeys, I., Wichers, M., Delespaul, P. A., van Os, J., & Bak, M. (2011). Psychotic exacerbation and emotional dampening in the daily life of patients with schizophrenia switched to aripiprazole therapy: a collection of standardized case reports. <i>Therapeutic advances in psychopharmacology</i>, <i>1</i>(5), 145-151.<br></div><div><br></div><div><b>DOI: 10.1177/2045125311419552</b><br></div