1 research outputs found
Three-Component, Four-Molecule, Ru-Catalyzed Cascade Reactions of Indoles and Alkyl Bromides with Sodium Nitrite
<div><p></p><p>An operationally simple domino approach for the ruthenium-catalyzed synthesis of (<i>E</i>)-2,3′-bi(3<i>H</i>-indol)-3-one <i>O</i>-alkyl oximes by the region- and stereoselective three-component, four-molecule reactions of indoles with sodium nitrite and alkyl bromides under mild reaction condition in dimethylformamide is described. Remarkably, multiple bonds including C‒C, C=N, and C‒O bonds were conveniently formed in one pot. The reaction is tolerant to air and is atom economical, in accordance with the concept of modern green chemistry.</p></div