MOESM4 of Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Additional file 4 : Figure S2. Kaplan-Meier survival curve of elderly patients with resectable proximal gastric carcinoma treated in different facility

MOESM2 of Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Additional file 2: Table S2. Treatment strategy of elderly patients with resectable proximal GC from NCDB database

MOESM1 of Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Additional file 1: Table S1. Comparison of baseline variables between surgery and no surgery group in the elderly patients with resectable proximal GC from NCDB database

MOESM3 of Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Additional file 3: Figure S1. a-b: Postoperative 30-day and 90-day mortality in different age groups of patients with resectable proximal gastric carcinoma (PGC). c-d: Postoperative 30-day and 90-day mortality of elderly patients with resectable PGC treated in different facility

Additional file 1 of Dietary novel alkaline protease from Bacillus licheniformis improves broiler meat nutritional value and modulates intestinal microbiota and metabolites

Additional file 1: Fig. S1. Effects of novel protease feed on growth performance (A). Effects of novel protease feed on antioxidant capacity of breast muscle (B). a−c Different lowercase letters indicate significant difference between groups (P < 0.05)

Table_1_The Apparent Diffusion Coefficient of Diffusion-Weighted Whole-Body Magnetic Resonance Imaging Affects the Survival of Multiple Myeloma Independently.xls

BackgroundDiffusion-weighted whole-body MRI (DW-MRI) is increasingly used to evaluate bone diseases of multiple myeloma (MM), but there is lack of quantitative indicator for DW-MRI to reflect the prognosis of MM. Apparent diffusion coefficient (ADC) values in DW-MRI has potential correlations between some indexes of MM, but the influence of ADC on MM survival needs to be further verified.MethodsA total of 381 newly diagnosed MM patients were enrolled in the study to analyze the effect of ADC values in DW-MRI on progression-free survival (PFS) and overall survival (OS). The Kaplan–Meier method was used to perform univariate survival analysis, and the Cox proportional hazards model was used for multivariate analysis. In addition to the ADC value, genetic and serological indexes were also included.ResultsThe survivals were observed in univariate ADC stratification with median PFS of 52.0, 45.0, 34.0, and 26.0 months (the unit of ADC value was 10−3 mm2/s; the ADC ranges were ADC ConclusionsThis study supports that ADC in DW-MRI may independently stratify MM patients and better predict their prognosis. The combined use of DW-MRI and other parameters allows more accurate evaluation of MM survival.Trial Registrationhttp://www.chictr.org.cn/showproj.aspx?proj=49012, ChiCTR2000029587.</p

Highly Stretchable and Self-Adhesive Wearable Biosensor Based on Nanozyme-Catalyzed Conductive Hydrogels

A highly stretchable and self-adhesive wearable biosensor is prepared from nanozyme-catalyzed conductive hydrogels. The hydrogels are first prepared from a nanozyme (Ta–Ag) based on polyphenol (tannic acid, Ta) chelate with metal ions (silver ion, Ag+), which possesses peroxidase (POD)-like activity. After that, a huge number of free radicals are formed by the interaction between the Ta–Ag NPs and ammonium persulfate (APS), which initiate the hydrogel polymerization via a facile “one-pot” compositing strategy without ultraviolet (UV) or thermal treatment. The homogeneous distribution of nanozymes in the interpenetrating network of sodium alginate (SA) and polyacrylamide (PAAm) realizes a dermis-mimicking structure in the flexible conductor, named Ta–Ag–SA/PAAm. It simultaneously improves the mechanical properties and conductivity. Similar to the adhesion of mussels, the nanozymes contain abundant phenolic hydroxyl groups, favoring the adhesiveness of hydrogels. Due to the capability of changing conductivity with the strain, the obtained hydrogels are able to accurately monitor different amplitudes of human activities in real time. In addition, the Ta–Ag nanozyme exhibits a good bacterial adhesion capability and thereby enhances the bactericidal efficiency of Ag. Based on the high performance of sensing and antibacterial activity, the obtained Ta–Ag–SA/PAAm hydrogels can be a promising candidate for a broad range of applications, such as adhesive epidemic biosensors and wearable medical patches