Graphene-like Poly(triazine imide) as N₂‑Selective Ultrathin Membrane for Postcombustion CO₂ Capture

To reduce the emission of greenhouse gases, the separation of CO₂ from flue gases emitted by power plants with combustion of carbon-based fossil fuels is of great importance. Compared with CO₂-selective membranes, N₂-selective membranes are more promising for such systems with low concentrations of CO₂. Using density functional theory (DFT) calculations and molecular dynamic (MD) simulations, we demonstrated in this work that the poly­(triazine imide) (PTI) membrane can be efficiently employed to separate N₂ from CO₂ with a selectivity of 273 and a N₂ permeance of 10⁶ GPU, superior to those of most conventional membranes. Furthermore, it was revealed that the presence of H₂O has a negligible influence on gas separation performance of the PTI membrane. This experimentally available N₂-selective ultrathin membrane may be expected to find practical applications in postcombustion CO₂ capture

Two-Dimensional Covalent Triazine Framework Membrane for Helium Separation and Hydrogen Purification

Ultrathin membranes with intrinsic pores are highly desirable for gas separation applications, because of their controllable pore sizes and homogeneous pore distribution and their intrinsic capacity for high flux. Two-dimensional (2D) covalent organic frameworks (COFs) with layered structures have periodically distributed uniform pores and can be exfoliated into ultrathin nanosheets. As a representative of 2D COFs, a monolayer triazine-based CTF-0 membrane is proposed in this work for effective separation of helium and purification of hydrogen on the basis of first-principles calculations. With the aid of diffusion barrier calculations, it was found that a monolayer CTF-0 membrane can exhibit exceptionally high He and H₂ selectivities over Ne, CO₂, Ar, N₂, CO, and CH₄, and the He and H₂ permeances are excellent at appropriate temperatures, superior to those of conventional carbon and silica membranes. These observations demonstrate that a monolayer CTF-0 membrane may be potentially useful for helium separation and hydrogen purification

Additional file 1 of Prediction of risk and clinical outcome of cuproptosis in lung squamous carcinoma

Additional file 1: Table S1. The list of cuproptosis-related genes. Table S2. The correlation between cuproptosis-related genes and OS in LUSC patients. Table S3. The list of 1233 DEGs. Table S4. Risk Score of train group. Table S5. Risk Score of test group. Table S6. Genes identified by Cox regression. Table S7. The relationship between the CRG score and the number of immune cells

Adsorption of CO₂, CH₄, and N₂ on 8‑, 10‑, and 12-Membered Ring Hydrophobic Microporous High-Silica Zeolites: DDR, Silicalite-1, and Beta

Three hydrophobic microporous high-silica zeolites, DDR (with an 8-membered ring), silicalite-1 (a 10-membered ring), and beta (a 12-membered ring) were synthesized. The Si/Al ratios were 230, 1350, and 35, respectively. The samples were characterized by X-ray diffraction, scanning electron microscopy, thermal gravimetric analysis, water vapor adsorption, and volumetric nitrogen adsorption. They were tested for their CO₂, CH₄, and N₂ adsorption properties at pressures of up to 10 bar at 288–313 K after activation, and the results were correlated with the Langmuir model. The heat of adsorption was calculated using the Clausius–Clapeyron equation based on the adsorption isotherms. These data were used to estimate the separation selectivities for CO₂/CH₄ and CH₄/N₂ binary mixtures at 298 K, using the ideal adsorbed solution theory (IAST) model. Experimental results showed that DDR and beta have good selectivities for CO₂/CH₄, because they have narrow pores (DDR) or more balance metal ions (relatively low Si/Al ratios beta) effect separately. The synthesized silicalite-1 has the lowest <i>S</i>_{<i>CO2/CH4</i>} but has the most suitable orifices for methane adsorption and the highest <i>S</i>_{<i>CH4/N2</i>}. In addition, the breakthrough data for CH₄/N₂ mixtures further indicates that silicalite-1 is more suitable for the CH₄ enrichment than the commercially used sorbents zeolite-5A and 13X. From the reproducibility of CH₄ and N₂ adsorption isotherms on silicalite-1, we can infer that which has the potential to be a commercial sorbent by the stable adsorption properties

Presentation_1_Long-term outcomes and cost-effectiveness evaluation of robot-assisted stereotactic hematoma drainage for spontaneous intracerebral hemorrhage.pdf

BackgroundTo investigate the long-term follow-up and economic estimation outcomes of hematoma drainage for spontaneous intracerebral hemorrhage (SICH) with the assistance of neurosurgical navigation and positioning planning system (referred to as robot).MethodsData were retrospectively obtained from consecutive patients with SICH who were admitted to our single-center between March 2019 and March 2022. Different minimally invasive surgery (MIS) procedures were performed according to the inclusion/exclusion criteria. The different groups were sampled and matched using the propensity score method, with age, sex, history of stroke, hypertension, bleeding volume and site of bleeding as matching variables, and matched with inverse probability weighting using R statistical analysis software. From the time of discharge up until 1 year after the surgery, records were gathered on clinical results and medical expenditures. An analysis was conducted to compare the costs and health outcomes of both robot-assisted stereotactic hematoma drainage and neuro-endoscopic surgery, considering both short-term and long-term effects. Health outputs were measured using modified Rankin scale (mRS) and quality adjusted life years (QALYs).ResultsOf the 142 patients, there were 77 patients in the robotic surgery group and 65 patients in the neuro-endoscopic surgery group. Propensity score sampling was matched, resulting in a balanced and comparable group of 37 patients in each, with the robotic surgery group [mean age (57.29 ± 12.74) years, 27 males (72.97%), hematoma volume (44.54 ± 10.49 ml), 22 deep location (59.46%)] and the neuro-endoscopic surgery group [mean age (57.27 ± 11.12) years, 27 males (72.97%), hematoma volume (44.70 ± 10.86 ml), 23 deep location (62.16%)]. At both three-month and one-year postoperative follow-up, the proportion of mRS scores ≤3 was higher in the robotic surgery group (45.95%,70.27%) than in the neuro-endoscopic surgery group (35.14%, 62.16%), but there was no statistically significant difference (P = 0.344, 0.461). One year after surgery, the robotic group demonstrated cost savings of ¥36,862.14 per individual and a gain of 0.062 QALYs compared to the neuro-endoscopic group.ConclusionOur calculations based on a model for SICH suggest that robotic-assisted stereotactic drainage offers health economic benefits due to its lower cost and higher effectiveness. However, to confirm these findings, more data from multicenter, prospective randomized controlled trials with larger sample sizes are needed.</p

Construction of a Ti-Based Bimetallic Metal–Organic Framework Using a One-Pot Method for Efficient C₂H₂/C₂H₄ and C₂H₂/CO₂ Separation

Titanium (Ti)-based metal-organic frameworks (Ti-MOFs) have attracted intensive research attention due to their low toxicity and high abundance of titanium. However, limited by the high reactivity of titanium species in the reaction system, the construction of Ti-MOFs still faces great challenges. Herein, we successfully introduced Ti into MOF-74 using a one-pot method. Powder X-ray diffraction (PXRD) combined with X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma (ICP) spectroscopy confirmed that the Ti(IV) ions were uniformly inserted into the MOF-74 structure. Our scanning electron microscopy (SEM)/energy-dispersive spectrometry (EDS) analysis showed that the Ti content was up to 44% with good sample homogeneity. The adsorption selectivity of Ti0.44/Ni0.56-MOF-74 at 1.0 bar and 298 K for C2H2/C2H4 and C2H2/CO2 (50/50, v/v) mixtures was 4.9 and 6.8, respectively, which are higher than that of pristine Ni-MOF-74. The results of our breakthrough simulation experiments revealed that the adsorption and separation performances of Ti0.44/Ni0.56-MOF-74 were greatly improved. This study provided insights for the construction of Ti-based bimetallic MOFs used for the separation of light hydrocarbons

Ultrasmall NiFe-Phosphate Nanoparticles Incorporated α‑Fe₂O₃ Nanoarrays Photoanode Realizing High Efficient Solar Water Splitting

The practical application of hematite (α-Fe₂O₃) in solar water splitting is severely limited by the highly charge recombination rate though its abundant reserves and suitable bandgap of ∼2.1 eV. This work describes the synthesis of ultrasmall NiFe-phosphate (NFP) nanoparticles incorporated α-Fe₂O₃ nanoarrays photoanode via a facile dip-coating and annealing process to demonstrate combined effects on enhanced photoelectrochemical (PEC) water oxidation. The NFP uniformly decorating on the surface of hematite nanorods not only could improve water oxidation kinetics and charge separation efficiency, but also could suppress the charge recombination in company with the surface states passivation. Furthermore, the phosphate (P) in the NFP nanoparticles could also play a synergistic effect on promoting the multiproton-coupled electron transfer (PCET) process for the PEC water oxidation. All of these lead to ∼140 mV cathodic shift of onset potential, ∼2.3-fold enhancement of the photocurrent and excellent long-term stability at 1.23 V_RHE in 0.1 M KOH solution for α-Fe₂O₃/NFP photoanode. Along with these advantages, the NFP nanoparticles may possess new opportunities for modulating PEC water oxidation performances in hematite and other metal oxide photoanodes

Covalent Triazine-Based Frameworks with Ultramicropores and High Nitrogen Contents for Highly Selective CO₂ Capture

Porous organic frameworks (POFs) are a class of porous materials composed of organic precursors linked by covalent bonds. The objective of this work is to develop POFs with both ultramicropores and high nitrogen contents for CO₂ capture. Specifically, two covalent triazine-based frameworks (CTFs) with ultramicropores (pores of width <7 Å) based on short (fumaronitrile, FUM) and wide monomers (1,4-dicyanonaphthalene, DCN) were synthesized. The obtained CTF-FUM and CTF-DCN possess excellent chemical and thermal stability with ultramicropores of 5.2 and 5.4 Å, respectively. In addition, they exhibit excellent ability to selectively capture CO₂ due to ultramicroporous nature. Especially, CTF-FUM-350 has the highest nitrogen content (27.64%) and thus the highest CO₂ adsorption capacity (57.2 cc/g at 298 K) and selectivities for CO₂ over N₂ and CH₄ (102.4 and 20.5 at 298 K, respectively) among all CTF-FUM and CTF-DCN. More impressively, as far as we know, the CO₂/CH₄ selectivity is larger than that of all reported CTFs and ranks in top 10 among all reported POFs. Dynamic breakthrough curves indicate that both CTFs could indeed separate gas mixtures of CO₂/N₂ and CO₂/CH₄ completely

Transition of LINE-1 DNA Methylation Status and Altered Expression in First and Third Trimester Placentas

<div><p>DNA methylation plays a critical role in the regulation of gene expression, genomic DNA stability, cell proliferation, and malignant transformation. Common cellular features including fast tissue expansion, invasive growth, and active angiogenesis, have been noticed between placental development and tumorigenesis by many investigators. While the DNA hypomethylation and transcriptional activation of LINE-1 has been found to be a feature of tumorigenesis, it is not clear if similar changes could be involved in placental development. In this study, we assessed LINE-1 methylation in human placentas from different gestational ages and observed a significant decrease of LINE-1 methylation levels in third trimester placentas compared to first trimester placentas. Accompanying with this change is the significantly increased LINE-1 mRNA levels in third trimester placentas. Since no global DNA methylation change was detected between first and third trimesters, LINE-1 methylation changes appeared to be a specific epigenetic entity contributing to placental development. Indeed, further analyses showed that LINE-1 upregulation was correlated with higher levels of PCNA, suggesting a link between LINE-1 activation and fast proliferation of certain cellular components in third trimester placentas. Measurement of the DNMT1, DNMT3A, and DNMT3B expression found a significant reduction of DNMT3B between third and first trimesters, pointing to the possible involvement of this enzyme in the regulation of LINE-1 methylation. Taken together these results provided evidence for a dynamic temporal regulation of LINE-1 methylation and activation during placental development. These studies have laid a foundation for future investigation on the function of LINE-1 expression in human placenta under different patho-physiological conditions.</p></div

Antenna-Protected Metal–Organic Squares for Water/Ammonia Uptake with Excellent Stability and Regenerability

Ammonia is a hazardous gas and the only carbon-free chemical energy carrier that can be largely adsorbed on metal–organic frameworks (MOFs). However, because of the destructive effect of H₂O/NH₃ on the metal nodes, most MOFs cannot be applied in ammonia capture and uptake. Herein, three Co-4,5-imidazoledicarboxylic series metal–organic squares (MOSs)Co₄(IDC)₄(pda)₄, Co₄(IDC)₄(phen)₄, and Co₄(IDC)₄(bpy)₄were synthesized with a special independent square configuration and zeolite-like supramolecular structures, and their structure and H₂O/NH₃ uptake capacity were investigated. Based on the four antennas-protected squares and porous structures, the three MOSs have excellent H₂O/NH₃ stability, whose structures were not affected by the ad-desorption of H₂O, NH₃, or H₂O/NH₃. The three MOFs have a H₂O uptake of 17.63, 8.35, and 7.75 mmol/g, respectively, as well as the facile release and repeatable of high ammonia uptakes of 11.5, 5.2, and 3.8 mmol/g, respectively. In addition, the MOFs have good stability and ammonia adsorption (4.73, 2.33, and 1.21 mmol/g, respectively) under humid conditions. Therefore, the three MOSs may be sustainably applied to ammonia uptake applications, because of their high ammonia uptake, ease of release, and the unique structural protection effect of the antenna ligands