Supplementary_Fig.1 – Supplemental material for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis

Supplemental material, Supplementary_Fig.1 for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis by Jinfeng Wang, Fengyuan Che and Jinling Zhang in The International Journal of Biological Markers</p

Supplementary_Fig.3 – Supplemental material for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis

Supplemental material, Supplementary_Fig.3 for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis by Jinfeng Wang, Fengyuan Che and Jinling Zhang in The International Journal of Biological Markers</p

Supplementary_Fig.2 – Supplemental material for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis

Supplemental material, Supplementary_Fig.2 for Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis by Jinfeng Wang, Fengyuan Che and Jinling Zhang in The International Journal of Biological Markers</p

Stretchable and Highly Sensitive Strain Sensor Based on a 2D MXene and 1D Whisker Carbon Nanotube Binary Composite Film

We fabricate a 2D MXene and 1D whisker carbon nanotube (WCNT) binary composite, where the MXene layer was sandwiched between two WCNT films, and assemble a flexible resistive-type strain sensor using this composite film. The deformations of the conductive networks trigged by the external mechanical stimuli cause the variations of the number of effective conductive paths, which result in the changes of the electric resistance of composite films. The resistances of the MXene/WCNT composite films that carry the strain information about the external mechanical stimuli are monitored. In addition, we demonstrate the role of the conductive MXene networks and the WCNT networks in responding to the external mechanical stimuli. The MXene networks dominate the variations of the resistance of the strain sensors in the low strain range. In the middle strain range, the deformations of both the MXene networks and the WCNT networks are responsible for the variations of the resistance of the strain sensors. In the high strain range, an “island bridge” like conductive network forms, where MXenes act as islands and WCNTs connect the adjacent MXene islands like bridges. The multiple types of conductive networks lead to the high sensitivity of the MXene/WCNT-based strain sensors over a wide strain range and a wide response window. This stretchable strain sensor exhibits good performances in detecting human muscle motions with a wide strain range and has the potentials of being applicable to wearable electronics

A Fluorescein-Substituted Perbrominated Dodecaborate Cluster as an Anchor Dye for Large Macrocyclic Hosts and Its Application in Indicator Displacement Assays

Perhalogenated boron clusters derived from B12Br122–, a superchaotropic dianion with a globular icosahedral shape, serve as inorganic cavity binders for cyclodextrins (CDs), in particular for large CDs (γ-CD and δ-CD), with high binding affinity (Ka > 106 M–1) in aqueous solution. This opens the door for applications of this anchoring moiety by linking it to organic residues, prominently fluorescent dyes. We report here the synthesis of a novel fluorescein-substituted perbrominated dodecaborate cluster by a copper(I)-catalyzed azide–alkyne click reaction. The formation of host–guest inclusion complexes between the dodecaborate-modified fluorescein dye and CDs can be readily followed by optical titrations, which afforded a binding constant of ∼1 × 104 M–1 with γ-CD; that is, the cluster functionalization allows binding of an otherwise nonbinding dye to the macrocycle (“anchor dye”). The formation of the 1:1 host–guest inclusion complex between the dye and γ-CD occurs over a broad range of pH values, which allows its application as a sensitive reporter pair according to the indicator displacement method, e.g., for drug detection. In addition, the substituted dye shows outer-wall binding to cucurbiturils through the dodecaborate moiety, leading to the formation of aggregates and significant fluorescence quenching of the dye

Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke

Danggui blood-supplementing decoction (DBsD) is an herbal preparation treating several diseases including stroke. The present study sought to investigate the potential mechanism of DBsD in ischaemic stroke (IS) using network pharmacology, molecular docking, and cell experiment. Based on the protein-protein (PPI) network analysis, MAPK1 (0.51, 12), KNG1 (0.57, 28), and TNF (0.64, 39) were found with relatively good performance in degree and closeness centrality. The functional enrichment analysis revealed that DBsD contributed to IS-related biological processes, molecule function, and presynaptic/postsynaptic cellular components. Pathway enrichment indicated that DBsD might protect IS by modulating multi-signalling pathways including the sphingolipid signalling pathway. Molecular docking verified the stigmasterol-KNG1, bifendate-TNF, and formononetin-MAPK1 pairs. Cell experiments confirmed the involvement of KNG1 and sphingolipid signalling pathway in hippocampal neuronal cell apoptosis. This study showed that DBsD can protect neuronal cell injury after IS through multiple components, multiple targets, and multiple pathways.</p

Image_1_Chronic social defeat stress caused region-specific oligodendrogenesis impairment in adolescent mice.pdf

IntroductionSocial stress in adolescents precipitates stress-related emotional disorders. In this study we aimed to investigate oligodendrogenesis in three stress-associated brain regions, medial prefrontal cortex (mPFC), habenula, and amygdala in adolescent mice exposed to social defeat stress.MethodsFour-week-old adolescent mice were subjected to social defeat for 10 days, followed by behavioral tests and evaluations of oligodendroglial proliferation and differentiation.ResultsStressed mice showed reduced social interaction, more stretched approach posture, lower sucrose preference, but no changes in the forced swimming test. EdU labeled proliferative cells, newly formed NG2+EdU + oligodendrocyte precursor cells (OPCs), and Olig2+EdU+ oligodendrocyte lineage cells (OLLs) were significantly decreased in the mPFC and the lateral habenula, but not in the amygdala and the medial habenula in socially defeated mice. APC+Edu+ newly-generated mature oligodendrocytes (OLs) were decreased in the mPFC in stressed mice. However, the total number of NG2+ OPCs, APC+ mature OLs, and Olig2+ OLLs were comparable in all the brain regions examined between stressed and control mice except for a decrease of APC+ mature OLs in the prelimbic cortex of stressed mice.ConclusionOur findings indicate that adolescent social stress causes emotion-related behavioral changes and region-specific impairment of oligodendrogenesis.</p

Additional file 1 of Deep learning–based automatic segmentation of meningioma from T1-weighted contrast-enhanced MRI for preoperative meningioma differentiation using radiomic features

Additional file 1: Supplementary Material 1. All ICCs between features extracted on manual and automatic Segmentation

Preparation of Superhydrophobic Coating on X80 Steel and Its Corrosion Resistance in Oilfield Produced Water

Corrosion is an unavoidable issue that steel encounters during service; however, the generic methods employed for corrosion prevention often need high cost or preparation conditions. In this study, a facile chemical replacement deposition method was proposed to realize an anticorrosion superhydrophobic coating on a X80 steel surface. The growth mechanism of the rough structure and its impact on the wettability of the superhydrophobic coating were analyzed. The superhydrophobic coating, deposited for 50 s and modified for 30 min, achieved optimal electrochemical properties and a maximum water contact angle. The immersion test, in the saturated CO2 oilfield produced water, demonstrated the better corrosion resistance of superhydrophobic coating than X80 steel. Correspondingly, a kinetic corrosion model was established to analyze the anticorrosion mechanism. In summary, this method significantly improves the corrosion resistance of X80 steel and is attractive for other industrial fields