Lithium Bromide-Promoted Formal C(sp³)–H Bond Insertion Reactions of β‑Carbonyl Esters with Sulfoxonium Ylides to Synthesize 1,4-Dicarbonyl Compounds

A LiBr-promoted formal C(sp3)–H bond insertion reaction between β-carbonyl esters and sulfoxonium ylides is established. This practical reaction has a wide range of substrate scope for both β-carbonyl esters and sulfoxonium ylides to give a variety of 1,4-dicarbonyl compounds with 43–94% yields. The reaction features transition-metal-free reaction conditions and exclusive C-alkylation chemselectivity. The use of bench-stable sulfoxonium ylides overcomes previous methods that require transition metal as catalysts and unstable diazo compounds or toxic haloketones as alkylation reagents

Additional file 2 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 2. sTable 1 The sample size of each 2-year survey circle in this Study

Additional file 6 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 6. sTable 5 Trend in prevalence of elevated triglyceride among US adults from 1999 to 2018

Additional file 10 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 10. sTable 9 Change in the distribution of characteristics among metabolic syndrome from 1999 to 2018

Additional file 5 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 5. sTable 4 Trend in prevalence of reduced HDL among US adults from 1999 to 2018

Additional file 20 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 20. sTable 19 Trend in control rate of HbA1camong metabolic syndrome from 1999 to 2018

Additional file 13 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 13. sTable 12 Change in distribution of characteristics among elevated triglyceride from 1999 to 2018

Additional file 11 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 11. sTable 10 Change in distribution of characteristics among elevated blood glucose from 1999 to 2018

Additional file 23 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 23. sTable 22 Trend in control rate of blood pressure among metabolic syndrome from 1999 to 2018

Additional file 18 of Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999–2018

Additional file 18. sTable 17 Trend in intervention of physical activity among metabolic syndrome from 1999 to 2018