Additional file 1 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 1: Figure S1. Mitochondrial genome sketch of A. amurensis (node ID marked in the figure). The orange color represents a major circular genome structure after resolving the duplicate region based on HiFi dat

Additional file 3 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 3: Table S1. Information about the Aquilegia sequences data previously published. Table S2. Annotated genes list in the mitochondrial genome of A. amurensis. Table S3. SSRs in the mitochondrial genome of A. amurensis. Table S4. Tandem repeat sequences in the mitochondrial genome of A. amurensi

Additional file 2 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 2: Figure S2. Phylogenetic relationships based on the mitochondrial genome of Aquilegia. The ML ultrafastbootstrap (ufbs) and BI posterior probability (PP) values are indicated above the branches. “*” are ufbs or PP of 10

Additional file 6 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 6: Table S7. Nontandem repeat sequences in the mitochondrial genome of A. amurensi

Additional file 5 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 5: Table S6. dN/dS ratios of each gene in the mitochondrial genome of Aquilegi

Additional file 4 of Characterizing complete mitochondrial genome of Aquilegia amurensis and its evolutionary implications

Supplementary Material 4: Table S5. Dispersed repeat sequences in the mitochondrial genome of A. amurensi

The Effect of Statin Therapy on Coronary Plaque Composition Using Virtual Histology Intravascular Ultrasound: A Meta-Analysis

<div><p>Objective</p><p>Previous studies have indicated that statin therapy may promote plaque regression. However, the impact of statin therapy on plaque composition has not been clearly elucidated. We performed a meta-analysis to investigate the effect of statin therapy on coronary plaque composition as assessed by virtual histology intravascular ultrasound (VH-IVUS).</p><p>Methods</p><p>Online databases were searched from inception to March 1, 2015. Studies providing VH-IVUS volumetric analyses of coronary plaque composition at baseline and follow-up in patients receiving statin therapy were included. Weighted mean difference (WMD) using a random-effects model was used.</p><p>Results</p><p>Ten studies involving 682 patients were included. There was a substantial reduction in fibrous volume between baseline and follow-up (WMD: -2.37 mm³, 95% confidence interval (CI) -4.01 to -0.74 mm³, P=0.004), and a significant increase in dense calcium (DC) volume (WMD: 0.89 mm³, 95% CI 0.70 to 1.08 mm³, P<0.00001). No significant change was seen in fibro-fatty and necrotic core (NC) volumes. In stratified analyses, the fibrous volume was decreased significantly (WMD: -3.39 mm³, 95% CI -6.56 to -0.21 mm³, P=0.04) and the absolute DC volume (WMD: 0.99 mm³, 95% CI 0.23 to 1.76 mm³, P=0.01) was increased in the subgroup with ≥12 months follow-up, whereas no significant change was observed in the subgroup with < 12 months follow-up. Similarly, a substantial decrease in fibrous volume (WMD: -2.01 mm³, 95% CI -3.05 to -0.96 mm³, P< 0.0002) and an increase in DC volume (WMD: 0.90 mm³, 95% CI 0.70 to 1.10 mm³, P< 0.00001) were observed in the subgroup with high-intensive statin therapy, while the change in fibrous and DC volumes approached statistical significance (P=0.05 and P=0.05, respectively) in the subgroup with low-intensive statin therapy.</p><p>Conclusions</p><p>Statin treatment, particularly of high-intensity and long-term duration, induced a marked modification in coronary plaque composition including a decrease in fibrous tissue and an increase in DC.</p></div

Changes in dense calcium volume between follow-up and baseline with statin therapy.

<p>Abbreviations: CI: confidence interval; SD: standard deviation.</p

Meta-analysis of changes in dense calcium volume with statin therapy using stratified analysis based on the intensity of statin therapy.

<p>Abbreviations: CI: confidence interval; SD: standard deviation.</p

Meta-analysis of changes in dense calcium volume with statin therapy using stratified analysis based on follow-up duration.

<p>Abbreviations: CI: confidence interval; SD: standard deviation.</p