Mutation diagram of <i>K-ras</i> in pancreatic adenocarcinoma.

<p>Mutation diagram of <i>K-ras</i> in pancreatic adenocarcinoma.</p

Overall survival analysis.

<p>Overall survival analysis.</p

Evaluation of <i>K-ras</i> and <i>p53</i> expression in pancreatic adenocarcinoma using the cancer genome atlas

<div><p>Genetic alterations in <i>K-ras</i> and <i>p53</i> are thought to be critical in pancreatic cancer development and progression. However, <i>K-ras</i> and <i>p53</i> expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding <i>K-ras</i> and <i>p53</i> alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in <i>K-ras</i> and <i>p53</i> were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1.599, <i>P</i> = 0.006). The graphical summary of the mutations showed that there were hotspots for protein activation. In the network analysis, no solid association between <i>K-ras</i> and <i>p53</i> was observed in pancreatic adenocarcinoma. In the survival analysis, neither <i>K-ras</i> nor <i>p53</i> were associated with both survival events. As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of <i>K-ras</i> and <i>p53</i> in pancreatic adenocarcinoma.</p></div

Mutation diagram of <i>p53</i> in pancreatic adenocarcinoma.

<p>Mutation diagram of <i>p53</i> in pancreatic adenocarcinoma.</p

Disease-free survival analysis.

<p>Disease-free survival analysis.</p

The OncoPrint tab.

<p>The OncoPrint tab.</p

Network analysis of the <i>K-ras</i> and <i>p53</i> neighborhood in pancreatic adenocarcinoma.

<p>Network analysis of the <i>K-ras</i> and <i>p53</i> neighborhood in pancreatic adenocarcinoma.</p

Data_Sheet_1_Decision tree model based prediction of the efficacy of acupuncture in methadone maintenance treatment.pdf

BackgroundPatients with MMT often face difficulties such as sleep disturbance, headaches, and difficulty in complete abstinence from drugs. Research has shown that acupuncture can mitigate side effects while attenuating methadone dependence. It also has a synergistic and attenuated effect on methadone maintenance treatment (MMT). Exploring the predictors of the efficacy of acupuncture intervention in MMT might help clinicians and patients promote acupuncture-assisted participation in MMT, and improve clinical treatment strategies for MMT.ObjectiveTo describe the effect of potential predictors on MMT after acupuncture intervention by building a decision-tree model of data from A Clinical Study of Acupuncture-assisted MMT.Design, setting, and participantsIn this randomized controlled trial, 135 patients with MMT underwent acupuncture at the Substance Dependence Department of Guangzhou Huiai Hospital in Guangzhou, Guangdong Province, China.InterventionA total of 135 patients were 1:1 randomly assigned to either an acupuncture plus routine care group (acupuncture plus methadone) or a routine group (methadone only) for 6 weeks, and followed up for 10 weeks. Sex, age, education level, route of previous opioid use, years of opioid use, and MMT time were recorded before the trial.Outcome measurements and statistical analysisAll analyses were based on the intention-to-treat (ITT) population. The two decision tree models used the change of methadone dosage and the VAS score for opioid desire as response variables, respectively, and the evaluation criteria were positive effect (decreased by ≥20%) and no effect (decreased by ResultsThe overall accuracy of methadone reduction and psychological craving VAS scoring decision trees were 0.63 and 0.74, respectively. The Methadone Dosage Efficacy decision tree identified years of opioid use (weight = 0.348), acupuncture (weight = 0.346), and route of previous opioid use (weight = 0.162) as key features. For the VAS Score decision tree, acupuncture (weight = 0.618), MMT time (weight = 0.235), and age (weight = 0.043) were the important features.ConclusionExploratory decision tree analysis showed that acupuncture, years of opioid use, route of previous opioid use, MMT time, and age were key predictors of the MMT treatment. Thus, acupuncture-assisted MMT strategy should consider the relevant influencing factors mentioned above.Patient summaryUnderstanding patient characteristics and the impact of acupuncture regimens on methadone dosage reduction in MMT patients may help physicians determine the best treatment regimen for patients. An analysis of data from our clinical trial showed that acupuncture, years of opioid use, route of previous opioid use, age, and MMT time were key predictors of progressive recovery in patients with MMT. Eligible patients may benefit most from the MMT rehabilitation that reduces consumption and psychological cravings for methadone.Clinical trial registrationhttp://www.chictr.org.cn/index.aspx, identifier: ChiCTR1900026357.</p

Data_Sheet_1_Research status and hotspots in the surgical treatment of tremor in Parkinson’s disease from 2002 to 2022: a bibliometric and visualization analysis.docx

ObjectiveThis study aims to investigate the research status and hotspots of surgical treatment for tremor in Parkinson’s disease (PD) from 2002 to 2022, utilizing bibliometric and visual analysis. Additionally, it aims to offer insights into future research trends in this field.MethodsThis study collected publications on the surgical treatment of tremor in PD from 2002 to 2022 using the Web of Science (WOS) database. CiteSpace, VOSviewer, and Scimago Graphica were employed to quantify the number of publications and analyze the bibliographic information networks, including the contributions of countries/cities, authors, keywords, and co-cited references.ResultsA total of 2,815 publications were included in the study, revealing that 541 scientific institutions experienced an increase in publications from 2002 to 2022. Michael Okun emerged as the most productive author, and the United States emerged as the leading hub for research. The study identified 772 keywords. Noteworthy citation bursts and long-term activity were observed in pallidotomy, bilateral stimulation, and focused ultrasound thalamotomy. The top 10 highly co-cited references comprised eight deep brain stimulation (DBS) studies (including two follow-up studies and six randomized controlled trials), one randomized controlled trial on focused ultrasound, and one consensus on tremor.ConclusionThis study uses an in-depth and systematic bibliometric and visualization analysis to visualize the evolution of research and identify emerging hotspots. The identified hotspots are as follows: Firstly, DBS has received significant attention and widespread recognition as a surgical treatment for tremor in PD. Secondly, there are various key aspects to consider in DBS, such as operative indications, operative targets, and surgical protocols. Lastly, magnetic resonance-guided focused ultrasound (MRgFUS) has emerged as a promising treatment option in the surgical management of tremor in Parkinson’s disease. This research also provides insights into the phenomenon of these hotspots, offering valuable prompts and reminders for further research.</p