124 research outputs found

    A feedback-driven bubble G24.136+00.436: a possible site of triggered star formation

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    We present a multi-wavelength study of the IR bubble G24.136+00.436. The J=1-0 observations of 12^{12}CO, 13^{13}CO and C18^{18}O were carried out with the Purple Mountain Observatory 13.7 m telescope. Molecular gas with a velocity of 94.8 km s1^{-1} is found prominently in the southeast of the bubble, shaping as a shell with a total mass of 2×104\sim2\times10^{4} MM_{\odot}. It is likely assembled during the expansion of the bubble. The expanding shell consists of six dense cores. Their dense (a few of 10310^{3} cm3^{-3}) and massive (a few of 10310^{3} MM_{\odot}) characteristics coupled with the broad linewidths (>> 2.5 km s1^{-1}) suggest they are promising sites of forming high-mass stars or clusters. This could be further consolidated by the detection of compact HII regions in Cores A and E. We tentatively identified and classified 63 candidate YSOs based on the \emph{Spitzer} and UKIDSS data. They are found to be dominantly distributed in regions with strong emission of molecular gas, indicative of active star formation especially in the shell. The HII region inside the bubble is mainly ionized by a \simO8V star(s), of the dynamical age \sim1.6 Myr. The enhanced number of candidate YSOs and secondary star formation in the shell as well as time scales involved, indicate a possible scenario of triggering star formation, signified by the "collect and collapse" process.Comment: 13 pages, 10 figures, 4 tables, accepted by Ap

    Research Directions and Projects In an Institute of Developmental Psychology in China

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    We are a team who maintained to focus on 3 fields in people’s mental health recent years: marriage and family research and therapy, mental health of middle and primary school students, and internet addiction in youth. In every field, we focus on both fundamental research and clinical practice. We aim to explore mechanisms using survey, observation and cognitive neuroscience methods (fMRI), and develop prediction and intervention projects based on research, to improve people’s life and policies

    Identification and validation of critical genes with prognostic value in gastric cancer

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    Background: Gastric cancer (GC) is a digestive system tumor with high morbidity and mortality rates. Molecular targeted therapies, including those targeting human epidermal factor receptor 2 (HER2), have proven to be effective in clinical treatment. However, better identification and description of tumor-promoting genes in GC is still necessary for antitumor therapy.Methods: Gene expression and clinical data of GC patients were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Last absolute shrinkage and selection operator (LASSO) Cox regression were applied to build a prognostic model, the Prognosis Score. Functional enrichment and single-sample gene set enrichment analysis (ssGSEA) were used to explore potential mechanisms. Western blotting, RNA interference, cell migration, and wound healing assays were used to detect the expression and function of myosin light chain 9 (MYL9) in GC.Results: A four-gene prognostic model was constructed and GC patients from TCGA and meta-GEO cohorts were stratified into high-prognosis score groups or low-prognosis score groups. GC patients in the high-prognosis score group had significantly poorer overall survival (OS) than those in the low-prognosis score groups. The GC prognostic model was formulated as PrognosisScore = (0.06 × expression of BGN) - (0.008 × expression of ATP4A) + (0.12 × expression of MYL9) - (0.01 × expression of ALDH3A1). The prognosis score was identified as an independent predictor of OS. High expression of MYL9, the highest weighted gene in the prognosis score, was correlated with worse clinical outcomes. Functional analysis revealed that MYL9 is mainly associated with the biological function of epithelial-mesenchymal transition (EMT). Knockdown of MYL9 expression inhibits migration of GC cells in vitro.Conclusion: We found that PrognosisScore is potential reliable prognostic marker and verified that MYL9 promotes the migration and metastasis of GC cells

    Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation.

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    Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hepatotoxicity in rats. We investigated Geniposide-induced hepatic injury in male Sprague-Dawley rats after 3-day intragastric administration of 100 mg/kg or 300 mg/kg Geniposide. Changes in hepatic histomorphology, serum liver enzyme, serum and hepatic bile acid profiles, and hepatic bile acid synthesis and transportation gene expression were measured. The 300 mg/kg Geniposide caused liver injury evidenced by pathological changes and increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamytransferase (γ-GT). While liver, but not sera, total bile acids (TBAs) were increased 75% by this dose, dominated by increases in taurine-conjugated bile acids (t-CBAs). The 300 mg/kg Geniposide also down-regulated expression of Farnesoid X receptor (FXR), small heterodimer partner (SHP) and bile salt export pump (BSEP). In conclusion, 300 mg/kg Geniposide can induce liver injury with associated changes in bile acid regulating genes, leading to an accumulation of taurine conjugates in the rat liver. Taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA) as well as tauro-α-muricholic acid (T-α-MCA) are potential markers for Geniposide-induced hepatic damage
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