Submission of Evidence on Online Violence Against Women to the UN Special Rapporteur on Violence Against Women, its Causes and Consequences, Dr Dubravka Šimonović

Figure S1. B3GALNT2 levels determined by W.B. and ROC curve. a–c Relative mRNA expression of B3GALNT2 in HCC tumor tissues and normal liver tissues obtained from GSE76427, GSE36376, and TCGA-LIHC datasets. d Western blot analysis of B3GALNT2 levels in 24 pairs of HCC tissues. T HCC tumor tissue, N adjacent non-tumor tissue. e ROC curve analysis of the sensitivity and specificity for the predictive value of TNM model, B3GALNT2 expression, and the combination model. (TIFF 546 kb

Learning Entrepreneurship with Serious Games - A Classroom Approach

The use of educational games for pedagogical practice can provide new conceptions of teaching-learning in an interactive environment stimulating the acquisition of new knowledge. The so-called serious games are focused on the goal of transmitting educational content or training to the user. In the context of entrepreneurship, serious games appear to have greater importance due to the multidisciplinary of the knowledge needed. Therefore, we propose the adoption of the Entrexplorer game in the context of a university classroom. The game is a cloud-based serious game about the theme of entrepreneurship where users can access learning contents that will assist them in the acquisition of entrepreneurial skills. The organization of the game in eight levels with six additional floors let students learn the different dimensions of an entrepreneurship project while progressing during the gameplay.Comment: 6 page

Algunas consideraciones sobre las opciones de Centroamérica en sus relaciones comerciales con los Estados Unidos

Incluye Bibliografí

Online Classroom dengan Pemanfaatan K12lessonplans Bagi Guru-guru SMP. H. Isriati Semarang

This society service is carried out using a free teacher website;www.k12lessonplans.com, in a form of training for teachers at SMP. H.Isriati Semarang. There are 15 teachers joining this training, which is heldon 14 ?óÔé¼ÔÇ£ 16 July, 2012, starting from 09:00 am - 02:00 pm. This trainingtakes place in the Computer Laboratory group and individual audience isconducted consecutively from 17 ?óÔé¼ÔÇ£ 21 July, 2012 and 23 ?óÔé¼ÔÇ£ 26 July startingfrom 02:00 ?óÔé¼ÔÇ£ 04:00 pm in the teachers?óÔé¼Ôäó longue at the school. This programis aimed to give the teachers knowledge and training, to implement onlineclassroom using the website. The methods used in this program are;explanation, question and answer, training and group guidance

Nondestructive testing of grating imperfections using grating-based X-ray phase-contrast imaging

We reported the usage of grating-based X-ray phase-contrast imaging in nondestructive testing of grating imperfections. It was found that electroplating flaws could be easily detected by conventional absorption signal, and in particular, we observed that the grating defects resulting from uneven ultraviolet exposure could be clearly discriminated with phase-contrast signal. The experimental results demonstrate that grating-based X-ray phase-contrast imaging, with a conventional low-brilliance X-ray source, a large field of view and a reasonable compact setup, which simultaneously yields phase- and attenuation-contrast signal of the sample, can be ready-to-use in fast nondestructive testing of various imperfections in gratings and other similar photoetching products.Comment: 6 pages, 5 figures and 2 table

Applying System of Systems Engineering(SoSE) to VIVO?

System of systems (SoS) refers to a set of operational and managerial independent systems interacting with each other to provide capabilities which cannot be accomplished by any single system. SoS has its own characteristics and challenges, such as emergent behavior and evolutionary development. This presentation will: <br><br>Introduce the concepts and characteristics of system of systems (SoS) and system thinking practice. <br>discuss SoS challenges using SoS case studies such as Global Earth Observation SoS <br>discuss how SoS Engineering process can be applied to networked research ecosystem in various areas such as community partnerships and SoS architecture

The official websites of blood centers in China: A nationwide cross-sectional study

<div><p>Background</p><p>Blood collection agencies worldwide are facing ongoing and increasing medical demands for blood products. Many potential donors would search related information online before making decision of whether or not to donate blood. However, there is little knowledge of the online information and services provided by blood centers in China, despite the constantly increase of internet users. Our research investigates the number of blood centers’ official websites and their quality, and highlights the deficiencies that required future advances.</p><p>Methods</p><p>Identified official websites of blood centers were scored using a newly developed evaluation instrument with 42 items concerning technical aspects, information quality, information comprehensiveness and interactive services. Scores of websites were compared between blood centers with different level (provincial vs. regional blood centers) and location (blood centers located in economically developed vs. developing region).</p><p>Results</p><p>For the 253 working official websites all the 350 blood centers in China, and the mean overall score of websites was 24.7 out of 42. 79.1% websites were rated as fair (50–75% of maximum), 5.5% as good (≥75% of maximum) and 15.4% as poor(25–50% of maximum;). Websites got very low sub-scores in information quality (mean = 3.8; range 1–8; maximum = 9) and interactive services (3.3; 0–10; 10). Higher proportions of provincial (vs. regional) blood centers and economically developed (vs. developing) blood centers had official websites (p = 0.044 and p = 0.001; respectively) with better overall quality (p<0.001 and p <0.01) and better sub-scores (in all of the four sections and in technical aspects and information quality). Website overall scores was positively correlated with the number of people served by each blood center (p< 0.001) and the donation rate of each province (p = 0.046).</p><p>Conclusions</p><p>This study suggests there is a need to further develop and improve official websites in China, especially for regional and inland blood centers. The poor information quality and interactive services provided by these websites is of particular concern, given the challenges in blood donor counselling and recruitment.</p></div

Pegylated Phospholipid Micelles Induce Endoplasmic Reticulum-Dependent Apoptosis of Cancer Cells but not Normal Cells

The rapid developments in nanotechnology have brought with them a deep concern over the safety of nanomaterials. Investigating the molecular mechanisms underlying their toxicity in different cell lines will help us better understand and apply nanomaterials appropriately. Poly(ethylene glycol)–phosphoethanolamine (PEG–PE) is an FDA-approved nonionic diblock copolymer and is widely used in drug delivery systems. Here, we find that PEG–PE accumulates in the endoplasmic reticulum (ER) and induces ER stress and that cancer cells and normal cells have different cell fates as a result of this stress. In A549 cancer cells, PEG–PE damages ER functions and triggers apoptosis by activating proapoptotic UPR signaling and high expression of cell death effector CHOP and proapoptotic Bax/Bak. In addition, PEG–PE-induced ER stress also up-regulates lipid synthesis and triggers lipid droplet formation in cancer cells. By contrast, in MRC-5 and 293T cells, high expression of the UPR feedback protein GADD34 which inhibits proapoptotic UPR signaling, and antiapoptotic Bcl-2 and Bcl-xl which down-regulate Bax/Bak, protect these normal cells from PEG–PE-induced apoptosis. When <i>gadd34</i>, <i>bcl-2</i>, or <i>bcl-xl</i> is knocked down, apoptosis occurs in PEG–PE-treated normal cells. In summary, we demonstrate the safety of PEG–PE in normal cells and elaborate the molecular mechanism underlying its nanotoxicity in cancer cells. This study implies PEG–PE-based drug delivery system has the potential to alter the sensitivity of cancer cells to some chemotherapeutic agents by selectively activating unfolded protein response (UPR) in cancer cells, and it also provides a useful foundation for research on ER stress-induced nanotoxicity and other lipid-based nanomaterials

Details of the studies included in the meta-analysis.

<p>Details of the studies included in the meta-analysis.</p

Percentage of websites presenting the specific item (%).

<p>Percentage of websites presenting the specific item (%).</p