Additional file 4: of Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain

Figure S2 Expression patterns of Syt2 in the hippocampus. (DOCX 2499 kb

Additional file 1: of Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain

Table S1 List of genes whose pattern of expression was different in the hippocampal tissues of IPMKcKO mice. (DOCX 14 kb

Additional file 2: of Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain

Materials and Methods. (DOCX 20 kb

Additional file 3: of Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain

Figure S1 Syt2 was upregulated in the hippocampus and amygdala after fear conditioning and extinction tests. (DOCX 286 kb

sj-zip-1-acr-10.1177_02841851221125994 - Supplemental material for Intra-individual comparison of lumbar spine CT, abdomen-pelvis contrast enhanced CT, and low-dose chest CT for bone density measurement

Supplemental material, sj-zip-1-acr-10.1177_02841851221125994 for Intra-individual comparison of lumbar spine CT, abdomen-pelvis contrast enhanced CT, and low-dose chest CT for bone density measurement by Jina Park, Bo Ram Kim, Eugene Lee and Joon Woo Lee in Acta Radiologica</p

sj-pdf-1-smm-10.1177_09622802231215801 - Supplemental material for A Bayesian adaptive biomarker stratified phase II randomized clinical trial design for radiotherapies with competing risk survival outcomes

Supplemental material, sj-pdf-1-smm-10.1177_09622802231215801 for A Bayesian adaptive biomarker stratified phase II randomized clinical trial design for radiotherapies with competing risk survival outcomes by Jina Park, Wenjing Hu, Ick Hoon Jin, Hao Liu and Yong Zang in Statistical Methods in Medical Research</p

Hexagonal Carbon Nanoplates Decorated with Layer-Engineered MoS₂: High-Performance Cathode Materials for Zinc-Ion Batteries

Hexagonal carbon nanoplates bearing MoS2 (HCN@MoS2) were synthesized using two-dimensional (2D) microporous organic polymers as templating materials. The layer number of MoS2 in HCN@MoS2 and the 2D morphology of composites were critical factors to achieve high-performance cathode materials for aqueous zinc-ion batteries. The best cathode performance was obtained with HCN@MoS2 bearing 2–3 layered MoS2 (HCN@MoS2-2), showing excellent discharge capacities of 602 mAh/g (@50 mA/g), 498 mAh/g (@0.1 A/g), and 328 mAh/g (@1 A/g). The promising electrochemical performance of HCN@MoS2-2 is attributable to the facilitated insertion of zinc ions into 2–3 layered MoS2 due to the reduced lattice energy and the efficient electrochemical utilization of composite materials

Mapping the research trends on the biological effects of radiation less than 100 mSv: a bibliometric analysis for 30 years publication

Purpose: The purpose of this study is to evaluate the global scientific publication of biological research of low dose radiation for the past 30 years and provide the insights into the characteristics of research activities and major topics regarding biological effects of low dose radiation exposure. Materials and methods: We bibliometrically investigated the biological research publication of radiation exposure less than 100 mSv. References published from 1987 to 2016 were achieved from the Scopus database and filtered by several criteria such as publication types, research fields, and radiation dose range. Results: Total 753 references were assembled for the bibliometric analysis on the biological studies of radiation effect less than 100 mSv. It provided fundamental knowledge of research, including production tendency, contribution, impact journals, and major research themes. Based on the keyword analysis, we found that specific topics on the biological response to radiation exposure have been changed from the examination of low dose radiation-induced phenomena to the investigation of how to induce a physiological response. In addition, featured articles showed the various views on the biological effects of radiation less than 100 mSv in 30 years publication, depending on radiation doses and types. Conclusions: Continuous studies in large programs of low dose radiation led to the increment of research achievements in accordance with societal needs in radiation safety regulation for health protection. Our findings can surely help radiation researchers to gain insights and penetration in low dose risk research for radiation protection, and establish a further research direction.</p

Proactive strategy for long-term biological research aimed at low-dose radiation risk in Korea

<p><b>Purpose:</b> Since the 2011 Fukushima nuclear power plant accident, Korean radiation experts have agreed that reliable data on health risks of low-dose radiation (LDR) are needed to ease the anxiety of lay people. The intent of this study was to devise a sustainable biological program suited for the research environment in Korea and aimed at the health effects of radiation exposures <100 millisieverts (mSv). To address pressing public concerns over LDR risk, we investigated the current understanding of LDR effects by analyzing the previous reports of international authorities for radiation protection and research publications that appeared after the Chernobyl accident. A research program appropriate for societal and scientific inclinations of Korea was then devised based on input from Korean radiation scientists.</p> <p><b>Conclusions:</b> After review by our advisory committee, program priorities were set, calling for an agenda that focused on dose-response relationships in carcinogenesis, health span responses to lifestyle variations, and systemic metabolic changes. Our long-term biological research program may contribute scientific evidence to reduce the uncertainties of LDR health risks and help stakeholders formulate policies for radiation protection.</p

dTULP, the <i>Drosophila melanogaster</i> Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

<div><p>Mechanically gated ion channels convert sound into an electrical signal for the sense of hearing. In <i>Drosophila melanogaster</i>, several transient receptor potential (TRP) channels have been implicated to be involved in this process. TRPN (NompC) and TRPV (Inactive) channels are localized in the distal and proximal ciliary zones of auditory receptor neurons, respectively. This segregated ciliary localization suggests distinct roles in auditory transduction. However, the regulation of this localization is not fully understood. Here we show that the <i>Drosophila</i> Tubby homolog, King tubby (hereafter called dTULP) regulates ciliary localization of TRPs. dTULP-deficient flies show uncoordinated movement and complete loss of sound-evoked action potentials. Inactive and NompC are mislocalized in the cilia of auditory receptor neurons in the <i>dTulp</i> mutants, indicating that dTULP is required for proper cilia membrane protein localization. This is the first demonstration that dTULP regulates TRP channel localization in cilia, and suggests that dTULP is a protein that regulates ciliary neurosensory functions.</p></div