Gold-Catalyzed Oxidative Cascade Cyclization of 1,3-Diynamides: Polycyclic N‑Heterocycle Synthesis via Construction of a Furopyridinyl Core

A facile and practical approach to construct a furopyridinyl motif through a gold-catalyzed cascade cyclization of easily accessible diynamides is described. This strategy offers a straightforward approach to furo­[2,3-c]­isoquinoline and 6H-furo­[3′,2′:5,6]­pyrido­[3,4-b]­indole derivatives. The reaction could build up four new bonds and two additional heteroaromatic rings via a single operation. The heterocyclic products show promising blue luminous performance with fluorescence quantum yields up to 75%

Supplementary document for Optomechanical squeezing with pulse modulation - 6056967.pdf

Solutions of Langevin Equations and comparison between the result with and without pulse modulation in phase spac

Divergent Access to Polycyclic <i>N</i>‑Heterocyclic Compounds through Büchner-Type Dearomatization Enabled Cycloisomerization of Diynamides under Gold Catalysis

Catalytic dearomatization has been considered as a valuable approach to convert readily accessible flat molecules to products with three-dimensional frameworks. Herein, an unprecedented gold-catalyzed oxidative Büchner-type cyclopropanation is described that enables the cycloisomerization of diynamides. By variation of the position of substituents on the phenyl ring, a variety of fused N-heterocyclic products with challenging structural skeletons were obtained divergently

Gold-Catalyzed Atom-Economic Synthesis of Sulfone-Containing Pyrrolo[2,1‑<i>a</i>]isoquinolines from Diynamides: Evidence for Consecutive Sulfonyl Migration

A gold-catalyzed cascade reaction of conjugated diynamides has been developed. In this way, a series of sulfone-containing pyrrolo­[2,1-a]­isoquinolines featuring the core structural motifs of lamellarin alkaloids were prepared atom economically. Mechanistic studies including DFT calculations uncovered a consecutive 1,2-migration of the sulfonyl group for the formation of a pyrrole ring

Gold-Catalyzed Atom-Economic Synthesis of Sulfone-Containing Pyrrolo[2,1‑<i>a</i>]isoquinolines from Diynamides: Evidence for Consecutive Sulfonyl Migration

A gold-catalyzed cascade reaction of conjugated diynamides has been developed. In this way, a series of sulfone-containing pyrrolo­[2,1-a]­isoquinolines featuring the core structural motifs of lamellarin alkaloids were prepared atom economically. Mechanistic studies including DFT calculations uncovered a consecutive 1,2-migration of the sulfonyl group for the formation of a pyrrole ring

Gold-Catalyzed Atom-Economic Synthesis of Sulfone-Containing Pyrrolo[2,1‑<i>a</i>]isoquinolines from Diynamides: Evidence for Consecutive Sulfonyl Migration

A gold-catalyzed cascade reaction of conjugated diynamides has been developed. In this way, a series of sulfone-containing pyrrolo­[2,1-a]­isoquinolines featuring the core structural motifs of lamellarin alkaloids were prepared atom economically. Mechanistic studies including DFT calculations uncovered a consecutive 1,2-migration of the sulfonyl group for the formation of a pyrrole ring

Association of clinical parameters with overall survival by Kaplan-Meier curves and the log-rank test.

<p><b>A.</b> AFP-normal, AFP-elevated or AFP-diagnostic patients. <b>B.</b> Patients with BCLC stages A+B or C. <b>C.</b> Patients with Child-Puge class A or B. <b>D.</b> Patients with or without satellite nodules. SN: satellite nodules.</p

Univariate and Multivariate Cox proportional hazards regression analysis of miRNAs in relation to HCC outcome.

<p>HR, hazard ratio; CI, confidence interval; miR, microRNA.</p><p>Univariate and Multivariate Cox proportional hazards regression analysis of miRNAs in relation to HCC outcome.</p

Perioperative Allogenenic Blood Transfusion Is Associated with Worse Clinical Outcomes for Hepatocellular Carcinoma: A Meta-Analysis

<div><p>Background and Objective</p><p>The impact of perioperative allogenenic blood transfusion (ABT) on clinical outcomes for hepatocellular carcinoma (HCC) is conflicting and unclear. The aim of this meta-analysis is to evaluate the association between ABT and HCC clinical outcomes. Outcomes evaluated were all-cause death, tumor recurrence and postoperative complications.</p> <p>Methods</p><p>Relevant articles were identified through MEDLINE search (up to November 2012). Meta-analyses were performed by using the fixed or random effect models. Study heterogeneity was assessed by Q-test and I² test. Publication bias was evaluated by funnel plots, Egger′s and Begg’s test.</p> <p>Results</p><p>A total of 5635 cases from 22 studies finally met our inclusion criteria. Meta-analysis indicated HCC patients with ABT had an increased risk of all-cause death at 3 and 5 years after surgery (respectively: OR = 1.92, 95% CI, 1.61–2.29,P<0.001; OR = 1.60, 95% CI, 1.47–1.73,P<0.001 ) compared with those without ABT. The risk of tumor recurrence was significantly higher for ABT cases at 1, 3 and 5 years (respectively: OR = 1.70, 95% CI, 1.38–2.10, P<0.001; OR = 1.22, 95% CI, 1.08–1.38, P<0.001; OR = 1.16, 95% CI, 1.08–1.24, P<0.001). The HCC cases with ABT significantly increased postoperative complications occurrence compared with non-ABT cases (OR = 1.78,95% CI, 1.34–2.37, P<0.001).</p> <p>Conclusions</p><p>The findings from the current meta-analysis demonstrated that ABT was associated with adverse clinical outcomes for HCC patients undergoing surgery, including increased death, recurrence and complications. Therefore, ABT should not be performed if possible.</p> </div

Receiver operating characteristic curve analysis for predicting prognostic accuracy of hepatocellular carcinoma with TACE treatment.

<p>ROC curves for the combination of AFP and satellite nodules, miR-200a and the combination of AFP, satellite nodules and miR-200a in total 136 patients and subgroup of HCC patients with normal (≤20 ng/ml), elevated (20–400 ng/ml) and diagnostic (>400 ng/ml) AFP level, respectively. The sensitivity, specificity and AUC were indicated below each ROC graph. SN: satellite nodules.</p